Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants

3 páginas, 2 figuras. 1 tabla y 1 figura en material suplementario y material suplementario de Material y Método

Detalles Bibliográficos
Autores: Boix, Julia, Nguyen, Van Tuan, Farman, Nicolette, Aractingi, Sélim, Pérez, Paloma
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/169911
Acceso en línea:http://hdl.handle.net/10261/169911
Access Level:acceso abierto
Palabra clave:Atrophy
Damage
Glucocorticoids
Mineralocorticoid receptor
Skin
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spelling Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explantsBoix, JuliaNguyen, Van TuanFarman, NicoletteAractingi, SélimPérez, PalomaAtrophyDamageGlucocorticoidsMineralocorticoid receptorSkin3 páginas, 2 figuras. 1 tabla y 1 figura en material suplementario y material suplementario de Material y MétodoWe recently demonstrated that blockade of the mineralocorticoid receptor (MR) effectively ameliorated GC-induced skin atrophy in healthy human skin explants and epidermal MR knockout mice. However, whether MR blockade improves the therapeutic index of glucocorticoids (GCs) in skin pathology was not investigated. We assessed the effects of GCs, MR antagonists (MRA) or both, in SDS-treated human skin explants. All treatments restored SDS-augmented epidermal thickness but only GC plus MRA restored the expression of COL1A1. However, MRA alone or in combination with GCs may exert a dual role in regulating inflammatory cytokines. Thus, although combined treatment may be beneficial to improve irritative skin, extensive in vivo testing is required to establish whether the anti-inflammatory effects of GCs are maintained in the presence of MRA.This work was supported by the Spanish Ministerio de Ciencia e Innovación (grant SAF2014-59474-R) and by the ADMIRE COST Action BM-1301Peer reviewedJohn Wiley & SonsMinisterio de Ciencia e Innovación (España)Pérez, Paloma [0000-0002-7166-2824]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/169911reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-59474-Rhttp://dx.doi.org/10.1111/exd.13473Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1699112026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants
title Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants
spellingShingle Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants
Boix, Julia
Atrophy
Damage
Glucocorticoids
Mineralocorticoid receptor
Skin
title_short Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants
title_full Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants
title_fullStr Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants
title_full_unstemmed Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants
title_sort Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants
dc.creator.none.fl_str_mv Boix, Julia
Nguyen, Van Tuan
Farman, Nicolette
Aractingi, Sélim
Pérez, Paloma
author Boix, Julia
author_facet Boix, Julia
Nguyen, Van Tuan
Farman, Nicolette
Aractingi, Sélim
Pérez, Paloma
author_role author
author2 Nguyen, Van Tuan
Farman, Nicolette
Aractingi, Sélim
Pérez, Paloma
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Pérez, Paloma [0000-0002-7166-2824]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Atrophy
Damage
Glucocorticoids
Mineralocorticoid receptor
Skin
topic Atrophy
Damage
Glucocorticoids
Mineralocorticoid receptor
Skin
description 3 páginas, 2 figuras. 1 tabla y 1 figura en material suplementario y material suplementario de Material y Método
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/169911
url http://hdl.handle.net/10261/169911
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-59474-R
http://dx.doi.org/10.1111/exd.13473
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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