Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls

This article belongs to the Special Issue Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies.

Detalles Bibliográficos
Autores: García-Gamboa, Ricardo, Díaz‑Torres, Osiris, Gradilla-Hernández, Misael Sebastian, Pérez-Brocal, Vicente, Moya, Andrés, González-Avila, Marisela
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/383492
Acceso en línea:http://hdl.handle.net/10261/383492
Access Level:acceso abierto
Palabra clave:Inflammatory bowel disease
16S rRNA gene sequencing
Gut microbiota
Nutritional influence
Bacillota/Bacteroidota (Firmicutes/Bacteroidetes)
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spelling Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controlsGarcía-Gamboa, RicardoDíaz‑Torres, OsirisGradilla-Hernández, Misael SebastianPérez-Brocal, VicenteMoya, AndrésGonzález-Avila, MariselaInflammatory bowel disease16S rRNA gene sequencingGut microbiotaNutritional influenceBacillota/Bacteroidota (Firmicutes/Bacteroidetes)This article belongs to the Special Issue Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies.The intestinal microbiota plays a key role in the pathogenesis of inflammatory bowel disease (IBD), with its composition varying based on geographic location and dietary factors. This study was performed to examine and compare the bacterial composition of the gut microbiota in Mexican and Spanish individuals with IBD and healthy controls, while also considering the nutritional aspects. This study involved 79 individuals with IBD and healthy controls from Mexico and Spain. The fecal microbiota composition was analyzed using 16S rRNA gene sequencing, and the dietary intake and anthropometric measurements were collected. Alpha diversity analysis revealed a lower Chao1 index of the bacterial genera in the IBD groups. Beta diversity analysis showed significant differences in the bacterial composition, suggesting inter-individual variability within the healthy and IBD groups. Additionally, the relative abundance of the bacterial genera varied across the four groups. Faecalibacterium was more abundant in the IBD groups; Prevotella was found exclusively in the Mexican groups, and Akkermansia was found only in the Spanish groups. Akkermansia was positively correlated with meat and protein intake, Prevotella with lean mass, and Bacteroides with calorie intake. These findings highlight the importance of considering geographic and nutritional factors in future research on the gut microbiome’s role in IBD pathogenesis.This research was funded by GenT grant, awarded to Vicente Pérez Brocal, code CDEI-06/20-E.Peer reviewedMultidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/383492reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/ijms252211887The sequence data for the 16S rRNA gene have been deposited in the EBI Short Read Archive repository https://www.ebi.ac.uk/enahttps://doi.org/10.3390/ijms252211887Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3834922026-05-22T06:33:51Z
dc.title.none.fl_str_mv Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls
title Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls
spellingShingle Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls
García-Gamboa, Ricardo
Inflammatory bowel disease
16S rRNA gene sequencing
Gut microbiota
Nutritional influence
Bacillota/Bacteroidota (Firmicutes/Bacteroidetes)
title_short Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls
title_full Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls
title_fullStr Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls
title_full_unstemmed Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls
title_sort Gut bacterial composition and nutritional implications in Mexican and Spanish individuals with inflammatory bowel disease compared to healthy controls
dc.creator.none.fl_str_mv García-Gamboa, Ricardo
Díaz‑Torres, Osiris
Gradilla-Hernández, Misael Sebastian
Pérez-Brocal, Vicente
Moya, Andrés
González-Avila, Marisela
author García-Gamboa, Ricardo
author_facet García-Gamboa, Ricardo
Díaz‑Torres, Osiris
Gradilla-Hernández, Misael Sebastian
Pérez-Brocal, Vicente
Moya, Andrés
González-Avila, Marisela
author_role author
author2 Díaz‑Torres, Osiris
Gradilla-Hernández, Misael Sebastian
Pérez-Brocal, Vicente
Moya, Andrés
González-Avila, Marisela
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Inflammatory bowel disease
16S rRNA gene sequencing
Gut microbiota
Nutritional influence
Bacillota/Bacteroidota (Firmicutes/Bacteroidetes)
topic Inflammatory bowel disease
16S rRNA gene sequencing
Gut microbiota
Nutritional influence
Bacillota/Bacteroidota (Firmicutes/Bacteroidetes)
description This article belongs to the Special Issue Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/383492
url http://hdl.handle.net/10261/383492
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/ijms252211887
The sequence data for the 16S rRNA gene have been deposited in the EBI Short Read Archive repository https://www.ebi.ac.uk/ena
https://doi.org/10.3390/ijms252211887
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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