Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction

Guillem Marti, Jordi; Vidal, Elia; Girotti ., Alessandra; Heras Parets, Aina; Torres, Diego; Arias Vallejo, Francisco Javier; Ginebra, M. P.; Rodríguez Cabello, José Carlos; Manero, José Maria

Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction

Producción Científica

Detalles Bibliográficos
Autores:	Guillem Marti, Jordi, Vidal, Elia, Girotti ., Alessandra, Heras Parets, Aina, Torres, Diego, Arias Vallejo, Francisco Javier, Ginebra, M. P., Rodríguez Cabello, José Carlos, Manero, José Maria
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Universidad de Valladolid
Repositorio:	UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:	oai:uvadoc.uva.es:10324/63729
Acceso en línea:	https://doi.org/10.3390/pharmaceutics15030872 https://uvadoc.uva.es/handle/10324/63729
Access Level:	acceso abierto
Palabra clave:	3D Printing Three-dimensional printing Impresión tridimensional Imágenes tridimensionales en medicina Diseño asistido por ordenador Polymers in medicine Polímeros recombinantes Polímeros - Aplicaciones médicas Biomaterials Biomateriales Osseointegration Titanium Pharmaceutical technology Pharmacology Functionalization 2206.10 Polímeros 2415 Biología Molecular 3209 Farmacología 3312 Tecnología de Materiales

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spelling	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinductionGuillem Marti, JordiVidal, EliaGirotti ., AlessandraHeras Parets, AinaTorres, DiegoArias Vallejo, Francisco JavierGinebra, M. P.Rodríguez Cabello, José CarlosManero, José Maria3D PrintingThree-dimensional printingImpresión tridimensionalImágenes tridimensionales en medicinaDiseño asistido por ordenadorPolymers in medicinePolímeros recombinantesPolímeros - Aplicaciones médicasBiomaterialsBiomaterialesOsseointegrationTitaniumPharmaceutical technologyPharmacologyFunctionalization2206.10 Polímeros2415 Biología Molecular3209 Farmacología3312 Tecnología de MaterialesProducción CientíficaThe 3D printing of titanium (Ti) offers countless possibilities for the development of personalized implants with suitable mechanical properties for different medical applications. However, the poor bioactivity of Ti is still a challenge that needs to be addressed to promote scaffold osseointegration. The aim of the present study was to functionalize Ti scaffolds with genetically modified elastin-like recombinamers (ELRs), synthetic polymeric proteins containing the elastin epitopes responsible for their mechanical properties and for promoting mesenchymal stem cell (MSC) recruitment, proliferation, and differentiation to ultimately increase scaffold osseointegration. To this end, ELRs containing specific cell-adhesive (RGD) and/or osteoinductive (SNA15) moieties were covalently attached to Ti scaffolds. Cell adhesion, proliferation, and colonization were enhanced on those scaffolds functionalized with RGD-ELR, while differentiation was promoted on those with SNA15-ELR. The combination of both RGD and SNA15 into the same ELR stimulated cell adhesion, proliferation, and differentiation, although at lower levels than those for every single moiety. These results suggest that biofunctionalization with SNA15-ELRs could modulate the cellular response to improve the osseointegration of Ti implants. Further investigation on the amount and distribution of RGD and SNA15 moieties in ELRs could improve cell adhesion, proliferation, and differentiation compared to the present study.Ministerio de Ciencia e Innovación y Fondo Europeo de Desarrollo Regional (FEDER) - (projects PID2021-125150OB-I00, DTS19/00162, and PID2019-106386RB-I00)MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/pharmaceutics15030872https://uvadoc.uva.es/handle/10324/63729reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/1999-4923/15/3/872info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/637292026-06-13T12:44:47Z
dc.title.none.fl_str_mv	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction
title	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction
spellingShingle	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction Guillem Marti, Jordi 3D Printing Three-dimensional printing Impresión tridimensional Imágenes tridimensionales en medicina Diseño asistido por ordenador Polymers in medicine Polímeros recombinantes Polímeros - Aplicaciones médicas Biomaterials Biomateriales Osseointegration Titanium Pharmaceutical technology Pharmacology Functionalization 2206.10 Polímeros 2415 Biología Molecular 3209 Farmacología 3312 Tecnología de Materiales
title_short	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction
title_full	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction
title_fullStr	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction
title_full_unstemmed	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction
title_sort	Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction
dc.creator.none.fl_str_mv	Guillem Marti, Jordi Vidal, Elia Girotti ., Alessandra Heras Parets, Aina Torres, Diego Arias Vallejo, Francisco Javier Ginebra, M. P. Rodríguez Cabello, José Carlos Manero, José Maria
author	Guillem Marti, Jordi
author_facet	Guillem Marti, Jordi Vidal, Elia Girotti ., Alessandra Heras Parets, Aina Torres, Diego Arias Vallejo, Francisco Javier Ginebra, M. P. Rodríguez Cabello, José Carlos Manero, José Maria
author_role	author
author2	Vidal, Elia Girotti ., Alessandra Heras Parets, Aina Torres, Diego Arias Vallejo, Francisco Javier Ginebra, M. P. Rodríguez Cabello, José Carlos Manero, José Maria
author2_role	author author author author author author author author
dc.subject.none.fl_str_mv	3D Printing Three-dimensional printing Impresión tridimensional Imágenes tridimensionales en medicina Diseño asistido por ordenador Polymers in medicine Polímeros recombinantes Polímeros - Aplicaciones médicas Biomaterials Biomateriales Osseointegration Titanium Pharmaceutical technology Pharmacology Functionalization 2206.10 Polímeros 2415 Biología Molecular 3209 Farmacología 3312 Tecnología de Materiales
topic	3D Printing Three-dimensional printing Impresión tridimensional Imágenes tridimensionales en medicina Diseño asistido por ordenador Polymers in medicine Polímeros recombinantes Polímeros - Aplicaciones médicas Biomaterials Biomateriales Osseointegration Titanium Pharmaceutical technology Pharmacology Functionalization 2206.10 Polímeros 2415 Biología Molecular 3209 Farmacología 3312 Tecnología de Materiales
description	Producción Científica
publishDate	2023
dc.date.none.fl_str_mv	2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.3390/pharmaceutics15030872 https://uvadoc.uva.es/handle/10324/63729
url	https://doi.org/10.3390/pharmaceutics15030872 https://uvadoc.uva.es/handle/10324/63729
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	https://www.mdpi.com/1999-4923/15/3/872
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid instname:Universidad de Valladolid
instname_str	Universidad de Valladolid
reponame_str	UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection	UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,300719

Functionalization of 3D-printed titanium scaffolds with elastin-like recombinamers to improve cell colonization and osteoinduction

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