Active Quantum Biomaterials-Enhanced Microrobots for Food Safety

Timely disruptive tools for the detection of pathogens in foods are needed to face global health and economic challenges. Herein, the utilization of quantum biomaterials-enhanced microrobots (QBEMRs) as autonomous mobile sensors designed for the precise detection of endotoxins originating from Salmo...

Descripción completa

Detalles Bibliográficos
Autores: Jyoti, Jyoti, Rodríguez Castillo, Alberto, Jurado Sánchez, Beatriz|||0000-0002-6584-1949, Pumera, Martin, Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/64462
Acceso en línea:http://hdl.handle.net/10017/64462
https://dx.doi.org/10.1002/smll.202404248
Access Level:acceso abierto
Palabra clave:Affinity peptide
Endotoxins
Fluorescence
Microrobots
Quantum materials
Química
Chemistry
id ES_40409aa8e61cece14e2d6eaee5f479c7
oai_identifier_str oai:ebuah.uah.es:10017/64462
network_acronym_str ES
network_name_str España
repository_id_str
spelling Active Quantum Biomaterials-Enhanced Microrobots for Food SafetyJyoti, JyotiRodríguez Castillo, AlbertoJurado Sánchez, Beatriz|||0000-0002-6584-1949Pumera, MartinEscarpa Miguel, Jesús Alberto|||0000-0002-7302-0948Affinity peptideEndotoxinsFluorescenceMicrorobotsQuantum materialsQuímicaChemistryTimely disruptive tools for the detection of pathogens in foods are needed to face global health and economic challenges. Herein, the utilization of quantum biomaterials-enhanced microrobots (QBEMRs) as autonomous mobile sensors designed for the precise detection of endotoxins originating from Salmonella enterica (S. enterica) as an indicator species for food-borne contamination globally is presented. A fluorescent molecule-labeled affinity peptide functions as a specific probe, is quenched upon binding to the surface of QBEMRs. Owing to its selective affinity for endotoxin, in the presence of S. enterica the fluorescence is restored and easy to observe and quantifies optical color change to indicate the presence of Salmonella. The devised approach is designed to achieve highly sensitive detection of the S. enterica serovar Typhimurium endotoxin with exquisite selectivity through the utilization of QBEMRs. Notably, no fluorescence signal is observed in the presence of endotoxins bearing similar structural characteristics, highlighting the selectivity of the approach during food sample analysis. Technically, the strategy is implemented in microplate readers to extend microrobots-based approaches to the routine laboratory. This new platform can provide fast and anticipated results in food safety.20242024-12-27journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/64462https://dx.doi.org/10.1002/smll.202404248reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/644622026-06-18T11:13:07Z
dc.title.none.fl_str_mv Active Quantum Biomaterials-Enhanced Microrobots for Food Safety
title Active Quantum Biomaterials-Enhanced Microrobots for Food Safety
spellingShingle Active Quantum Biomaterials-Enhanced Microrobots for Food Safety
Jyoti, Jyoti
Affinity peptide
Endotoxins
Fluorescence
Microrobots
Quantum materials
Química
Chemistry
title_short Active Quantum Biomaterials-Enhanced Microrobots for Food Safety
title_full Active Quantum Biomaterials-Enhanced Microrobots for Food Safety
title_fullStr Active Quantum Biomaterials-Enhanced Microrobots for Food Safety
title_full_unstemmed Active Quantum Biomaterials-Enhanced Microrobots for Food Safety
title_sort Active Quantum Biomaterials-Enhanced Microrobots for Food Safety
dc.creator.none.fl_str_mv Jyoti, Jyoti
Rodríguez Castillo, Alberto
Jurado Sánchez, Beatriz|||0000-0002-6584-1949
Pumera, Martin
Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948
author Jyoti, Jyoti
author_facet Jyoti, Jyoti
Rodríguez Castillo, Alberto
Jurado Sánchez, Beatriz|||0000-0002-6584-1949
Pumera, Martin
Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948
author_role author
author2 Rodríguez Castillo, Alberto
Jurado Sánchez, Beatriz|||0000-0002-6584-1949
Pumera, Martin
Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948
author2_role author
author
author
author
dc.subject.none.fl_str_mv Affinity peptide
Endotoxins
Fluorescence
Microrobots
Quantum materials
Química
Chemistry
topic Affinity peptide
Endotoxins
Fluorescence
Microrobots
Quantum materials
Química
Chemistry
description Timely disruptive tools for the detection of pathogens in foods are needed to face global health and economic challenges. Herein, the utilization of quantum biomaterials-enhanced microrobots (QBEMRs) as autonomous mobile sensors designed for the precise detection of endotoxins originating from Salmonella enterica (S. enterica) as an indicator species for food-borne contamination globally is presented. A fluorescent molecule-labeled affinity peptide functions as a specific probe, is quenched upon binding to the surface of QBEMRs. Owing to its selective affinity for endotoxin, in the presence of S. enterica the fluorescence is restored and easy to observe and quantifies optical color change to indicate the presence of Salmonella. The devised approach is designed to achieve highly sensitive detection of the S. enterica serovar Typhimurium endotoxin with exquisite selectivity through the utilization of QBEMRs. Notably, no fluorescence signal is observed in the presence of endotoxins bearing similar structural characteristics, highlighting the selectivity of the approach during food sample analysis. Technically, the strategy is implemented in microplate readers to extend microrobots-based approaches to the routine laboratory. This new platform can provide fast and anticipated results in food safety.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-12-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/64462
https://dx.doi.org/10.1002/smll.202404248
url http://hdl.handle.net/10017/64462
https://dx.doi.org/10.1002/smll.202404248
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406730318774272
score 15.81155

Similares en LA Referencia