2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue
Activation of non-shivering thermogenesis () in brown adipose tissue () has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients. It is therefore important to identify novel regulators of and cold-induced...
| Autores: | , , , , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2016 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositório: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglês |
| OAI Identifier: | oai:ddd.uab.cat:185765 |
| Acesso em linha: | https://ddd.uab.cat/record/185765 https://dx.doi.org/urn:doi:10.15252/emmm.201505610 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Brown adipose tissue Glucose uptake 2 Thermogenesis Metabolism |
| Resumo: | Activation of non-shivering thermogenesis () in brown adipose tissue () has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients. It is therefore important to identify novel regulators of and cold-induced glucose uptake. Mammalian target of rapamycin complex 2 (2) mediates insulin-stimulated glucose uptake in metabolic tissues, but its role in is unknown. We show that 2 is activated in brown adipocytes upon β-adrenergic stimulation. Furthermore, mice lacking 2 specifically in adipose tissue (AdRi mice) are hypothermic, display increased sensitivity to cold, and show impaired cold-induced glucose uptake and glycolysis. Restoration of glucose uptake in by overexpression of hexokinase or activated Akt2 was sufficient to increase body temperature and improve cold tolerance in AdRi mice. Thus, 2 in mediates temperature homeostasis via regulation of cold-induced glucose uptake. Our findings demonstrate the importance of glucose metabolism in temperature regulation. |
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