Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis

Background and objectivesThe impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).MethodsAntibody response...

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Detalles Bibliográficos
Autores: Comabella, Manuel, Hegen, Harald, Villar, Luisa M., Rejdak, Konrad, Sao Avilés, Augusto, Behrens, Malina, Sastre Garriga, Jaume, Mongay, Neus, Berek, Klaus, Martínez Yélamos, Sergio, Pérez Miralles, Francisco, Abdelhak, Ahmed, Bachhuber, Franziska, Tumani, Hayrettin, Lycke, Jan, Carbonell Mirabent, Pere, Valls Carbó, Adrián, Rosenstein, Igal, Alvarez Lafuente, Roberto, Castillo Triviño, Tamara, Otaegui, David, Llufriu Duran, Sara, Blanco Morgado, Yolanda, Sánchez López, Antonio J., García Merino, Antonio, Fissolo, Nicolás, Gutiérrez, Lucía, Villacieros Álvarez, Javier, Monreal, Enric, Wiendl, Heinz, Montalban, Xavier, Lünemann, Jan D.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219574
Acceso en línea:https://hdl.handle.net/2445/219574
Access Level:acceso abierto
Palabra clave:Esclerosi múltiple
Citomegalovirus
Multiple sclerosis
Cytomegaloviruses
Descripción
Sumario:Background and objectivesThe impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).MethodsAntibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.ResultsCompared with controls, PPMS patients showed increased humoral immune responses to the EBV-encoded nuclear antigen-1 (EBNA1), but not to the lytic EBV capsid antigen (VCA) or to other viral antigens. Seroprevalence rates for HCMV were significantly higher in PPMS. Antiviral immune responses at baseline did not correlate with disability progression over time.DiscussionElevated immune responses toward EBNA1 are selectively increased in people with primary progressive disease, indicating a link between EBNA1-targeting immune responses and the development of both RMS and PPMS. Our data also suggest that chronic HCMV infection is associated with progressive MS.

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