Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction
The administration of extracellular vesicles (EV) from mesenchymal stromal cells (MSC) is a promising cell-free nanotherapy for tissue repair after myocardial infarction (MI). However, the optimal EV delivery strategy remains undetermined. Here, we designed a novel MSC-EV delivery, using 3D scaffold...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:238253 |
| Acesso em linha: | https://ddd.uab.cat/record/238253 https://dx.doi.org/urn:doi:10.1016/j.bioactmat.2021.02.026 |
| Access Level: | acceso abierto |
| Palavra-chave: | Exosomes Mesenchymal stem/stromal cells Migration Infiltration Cardiac tissue engineering |
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| dc.title.none.fl_str_mv |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction |
| title |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction |
| spellingShingle |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction Monguió-Tortajada, Marta|||0000-0003-2125-0810 Exosomes Mesenchymal stem/stromal cells Migration Infiltration Cardiac tissue engineering |
| title_short |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction |
| title_full |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction |
| title_fullStr |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction |
| title_full_unstemmed |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction |
| title_sort |
Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction |
| dc.creator.none.fl_str_mv |
Monguió-Tortajada, Marta|||0000-0003-2125-0810 Prat-Vidal, Cristina|||0000-0002-5621-1101 Font-Morón, Miriam|||0000-0002-4714-252X Clos Sansalvador, Marta|||0000-0001-8522-7818 Calle Arias, Alexandra|||0000-0003-3903-5019 Gastelurrutia, Paloma|||0000-0001-6974-9210 Cserkóová, Adriana Morancho, Anna|||0000-0001-9059-3206 Ramírez de Paz, Miguel Ángel|||0000-0002-5868-2134 Rosell Novel, Anna|||0000-0003-1082-3599 Bayés-Genís, Antoni|||0000-0002-3044-197X Gálvez-Montón, Carolina|||0000-0003-2254-9371 Borràs i Serres, Francesc Enric|||0000-0003-4038-1912 Rudilla, F.. |
| author |
Monguió-Tortajada, Marta|||0000-0003-2125-0810 |
| author_facet |
Monguió-Tortajada, Marta|||0000-0003-2125-0810 Prat-Vidal, Cristina|||0000-0002-5621-1101 Font-Morón, Miriam|||0000-0002-4714-252X Clos Sansalvador, Marta|||0000-0001-8522-7818 Calle Arias, Alexandra|||0000-0003-3903-5019 Gastelurrutia, Paloma|||0000-0001-6974-9210 Cserkóová, Adriana Morancho, Anna|||0000-0001-9059-3206 Ramírez de Paz, Miguel Ángel|||0000-0002-5868-2134 Rosell Novel, Anna|||0000-0003-1082-3599 Bayés-Genís, Antoni|||0000-0002-3044-197X Gálvez-Montón, Carolina|||0000-0003-2254-9371 Borràs i Serres, Francesc Enric|||0000-0003-4038-1912 Rudilla, F.. |
| author_role |
author |
| author2 |
Prat-Vidal, Cristina|||0000-0002-5621-1101 Font-Morón, Miriam|||0000-0002-4714-252X Clos Sansalvador, Marta|||0000-0001-8522-7818 Calle Arias, Alexandra|||0000-0003-3903-5019 Gastelurrutia, Paloma|||0000-0001-6974-9210 Cserkóová, Adriana Morancho, Anna|||0000-0001-9059-3206 Ramírez de Paz, Miguel Ángel|||0000-0002-5868-2134 Rosell Novel, Anna|||0000-0003-1082-3599 Bayés-Genís, Antoni|||0000-0002-3044-197X Gálvez-Montón, Carolina|||0000-0003-2254-9371 Borràs i Serres, Francesc Enric|||0000-0003-4038-1912 Rudilla, F.. |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Exosomes Mesenchymal stem/stromal cells Migration Infiltration Cardiac tissue engineering |
| topic |
Exosomes Mesenchymal stem/stromal cells Migration Infiltration Cardiac tissue engineering |
| description |
The administration of extracellular vesicles (EV) from mesenchymal stromal cells (MSC) is a promising cell-free nanotherapy for tissue repair after myocardial infarction (MI). However, the optimal EV delivery strategy remains undetermined. Here, we designed a novel MSC-EV delivery, using 3D scaffolds engineered from decellularised cardiac tissue as a cell-free product for cardiac repair. EV from porcine cardiac adipose tissue-derived MSC (cATMSC) were purified by size exclusion chromatography (SEC), functionally analysed and loaded to scaffolds. cATMSC-EV markedly reduced polyclonal proliferation and pro-inflammatory cytokines production (IFNγ, TNFα, IL12p40) of allogeneic PBMC. Moreover, cATMSC-EV recruited outgrowth endothelial cells (OEC) and allogeneic MSC, and promoted angiogenesis. Fluorescently labelled cATMSC-EV were mixed with peptide hydrogel, and were successfully retained in decellularised scaffolds. Then, cATMSC-EV-embedded pericardial scaffolds were administered in vivo over the ischemic myocardium in a pig model of MI. Six days from implantation, the engineered scaffold efficiently integrated into the post-infarcted myocardium. cATMSC-EV were detected within the construct and MI core, and promoted an increase in vascular density and reduction in macrophage and T cell infiltration within the damaged myocardium. The confined administration of multifunctional MSC-EV within an engineered pericardial scaffold ensures local EV dosage and release, and generates a vascularised bioactive niche for cell recruitment, engraftment and modulation of short-term post-ischemic inflammation. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/238253 https://dx.doi.org/urn:doi:10.1016/j.bioactmat.2021.02.026 |
| url |
https://ddd.uab.cat/record/238253 https://dx.doi.org/urn:doi:10.1016/j.bioactmat.2021.02.026 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-301 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1427 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-483 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-84324-C2-1-R Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-110137RB-I00 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-107145RB-I00 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17-01487 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PIC18-00014 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI19-00039 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18-00256 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18-01227 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI20-00135 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0009 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0011-0006 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CB16-11-00403 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2019-PROD-00122 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII15-00003 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-00981 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarctionMonguió-Tortajada, Marta|||0000-0003-2125-0810Prat-Vidal, Cristina|||0000-0002-5621-1101Font-Morón, Miriam|||0000-0002-4714-252XClos Sansalvador, Marta|||0000-0001-8522-7818Calle Arias, Alexandra|||0000-0003-3903-5019Gastelurrutia, Paloma|||0000-0001-6974-9210Cserkóová, AdrianaMorancho, Anna|||0000-0001-9059-3206Ramírez de Paz, Miguel Ángel|||0000-0002-5868-2134Rosell Novel, Anna|||0000-0003-1082-3599Bayés-Genís, Antoni|||0000-0002-3044-197XGálvez-Montón, Carolina|||0000-0003-2254-9371Borràs i Serres, Francesc Enric|||0000-0003-4038-1912Rudilla, F..ExosomesMesenchymal stem/stromal cellsMigrationInfiltrationCardiac tissue engineeringThe administration of extracellular vesicles (EV) from mesenchymal stromal cells (MSC) is a promising cell-free nanotherapy for tissue repair after myocardial infarction (MI). However, the optimal EV delivery strategy remains undetermined. Here, we designed a novel MSC-EV delivery, using 3D scaffolds engineered from decellularised cardiac tissue as a cell-free product for cardiac repair. EV from porcine cardiac adipose tissue-derived MSC (cATMSC) were purified by size exclusion chromatography (SEC), functionally analysed and loaded to scaffolds. cATMSC-EV markedly reduced polyclonal proliferation and pro-inflammatory cytokines production (IFNγ, TNFα, IL12p40) of allogeneic PBMC. Moreover, cATMSC-EV recruited outgrowth endothelial cells (OEC) and allogeneic MSC, and promoted angiogenesis. Fluorescently labelled cATMSC-EV were mixed with peptide hydrogel, and were successfully retained in decellularised scaffolds. Then, cATMSC-EV-embedded pericardial scaffolds were administered in vivo over the ischemic myocardium in a pig model of MI. Six days from implantation, the engineered scaffold efficiently integrated into the post-infarcted myocardium. cATMSC-EV were detected within the construct and MI core, and promoted an increase in vascular density and reduction in macrophage and T cell infiltration within the damaged myocardium. The confined administration of multifunctional MSC-EV within an engineered pericardial scaffold ensures local EV dosage and release, and generates a vascularised bioactive niche for cell recruitment, engraftment and modulation of short-term post-ischemic inflammation. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/238253https://dx.doi.org/urn:doi:10.1016/j.bioactmat.2021.02.026reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-301Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1427Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-483Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-84324-C2-1-RAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-110137RB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-107145RB-I00Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17-01487Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PIC18-00014Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI19-00039Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18-00256Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18-01227Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI20-00135Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0009Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16-0011-0006Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CB16-11-00403Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2019-PROD-00122Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII15-00003Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-00981open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2382532026-06-06T12:50:31Z |
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