Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis
[Background] The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/122573 |
| Acceso en línea: | http://hdl.handle.net/10261/122573 |
| Access Level: | acceso abierto |
| Palabra clave: | Dioxin receptor Aldehyde dehydrogenase Tumorigenesis Lung metastasis Cancer stem cells Invasion |
| Sumario: | [Background] The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels with respect to benign nevi. |
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