Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model

Galectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification. We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) could reduce aortic and AV remodeling in normotensive rats with pressure overload (PO). Six weeks after aortic constr...

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Authors: Ibarrola, Jaime, Martínez Martínez, Ernesto, Sádaba, J., Arrieta, Vanessa, García Peña, Amaia, Álvarez, Virginia, Fernández Celis, Amaya, Gainza, Alicia, Rossignol, Patrick, Cachofeiro Ramos, María Victoria, López Andrés, Natalia
Format: article
Publication Date:2017
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/19166
Online Access:https://hdl.handle.net/20.500.14352/19166
Access Level:Open access
Keyword:Galectin-3
Pressure overload
Aorta
Valve
Cardiología
Fisiología
3205.01 Cardiología
2411 Fisiología Humana
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spelling Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload ModelIbarrola, JaimeMartínez Martínez, ErnestoSádaba, J.Arrieta, VanessaGarcía Peña, AmaiaÁlvarez, VirginiaFernández Celis, AmayaGainza, AliciaRossignol, PatrickCachofeiro Ramos, María VictoriaLópez Andrés, NataliaGalectin-3Pressure overloadAortaValveCardiologíaFisiología3205.01 Cardiología2411 Fisiología HumanaGalectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification. We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) could reduce aortic and AV remodeling in normotensive rats with pressure overload (PO). Six weeks after aortic constriction, vascular Gal-3 expression was up-regulated in male Wistar rats. Gal-3 overexpression was accompanied by an increase in the aortic media layer thickness, enhanced total collagen, and augmented expression of fibrotic mediators. Further, vascular inflammatory markers as well as inflammatory cells content were greater in aorta from PO rats. MCP treatment (100 mg/kg/day) prevented the increase in Gal-3, media thickness, fibrosis, and inflammation in the aorta of PO rats. Gal-3 levels were higher in AVs from PO rats. This paralleled enhanced AV fibrosis, inflammation, as well as greater expression of calcification markers. MCP treatment prevented the increase in Gal-3 as well as fibrosis, inflammation, and calcification in AVs. Overall, Gal-3 is overexpressed in aorta and AVs from PO rats. Gal-3 pharmacological inhibition blocks aortic and AV remodeling in experimental PO. Gal-3 could be a new therapeutic approach to delay the progression and the development of aortic remodeling and AV calcification in PO.MDPIUniversidad Complutense de Madrid20172017-07-3120172017-07-31journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/19166reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/191662026-06-02T12:44:21Z
dc.title.none.fl_str_mv Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model
title Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model
spellingShingle Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model
Ibarrola, Jaime
Galectin-3
Pressure overload
Aorta
Valve
Cardiología
Fisiología
3205.01 Cardiología
2411 Fisiología Humana
title_short Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model
title_full Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model
title_fullStr Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model
title_full_unstemmed Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model
title_sort Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model
dc.creator.none.fl_str_mv Ibarrola, Jaime
Martínez Martínez, Ernesto
Sádaba, J.
Arrieta, Vanessa
García Peña, Amaia
Álvarez, Virginia
Fernández Celis, Amaya
Gainza, Alicia
Rossignol, Patrick
Cachofeiro Ramos, María Victoria
López Andrés, Natalia
author Ibarrola, Jaime
author_facet Ibarrola, Jaime
Martínez Martínez, Ernesto
Sádaba, J.
Arrieta, Vanessa
García Peña, Amaia
Álvarez, Virginia
Fernández Celis, Amaya
Gainza, Alicia
Rossignol, Patrick
Cachofeiro Ramos, María Victoria
López Andrés, Natalia
author_role author
author2 Martínez Martínez, Ernesto
Sádaba, J.
Arrieta, Vanessa
García Peña, Amaia
Álvarez, Virginia
Fernández Celis, Amaya
Gainza, Alicia
Rossignol, Patrick
Cachofeiro Ramos, María Victoria
López Andrés, Natalia
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Galectin-3
Pressure overload
Aorta
Valve
Cardiología
Fisiología
3205.01 Cardiología
2411 Fisiología Humana
topic Galectin-3
Pressure overload
Aorta
Valve
Cardiología
Fisiología
3205.01 Cardiología
2411 Fisiología Humana
description Galectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification. We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) could reduce aortic and AV remodeling in normotensive rats with pressure overload (PO). Six weeks after aortic constriction, vascular Gal-3 expression was up-regulated in male Wistar rats. Gal-3 overexpression was accompanied by an increase in the aortic media layer thickness, enhanced total collagen, and augmented expression of fibrotic mediators. Further, vascular inflammatory markers as well as inflammatory cells content were greater in aorta from PO rats. MCP treatment (100 mg/kg/day) prevented the increase in Gal-3, media thickness, fibrosis, and inflammation in the aorta of PO rats. Gal-3 levels were higher in AVs from PO rats. This paralleled enhanced AV fibrosis, inflammation, as well as greater expression of calcification markers. MCP treatment prevented the increase in Gal-3 as well as fibrosis, inflammation, and calcification in AVs. Overall, Gal-3 is overexpressed in aorta and AVs from PO rats. Gal-3 pharmacological inhibition blocks aortic and AV remodeling in experimental PO. Gal-3 could be a new therapeutic approach to delay the progression and the development of aortic remodeling and AV calcification in PO.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-07-31
2017
2017-07-31
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/19166
url https://hdl.handle.net/20.500.14352/19166
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406702272512001
score 15,300719

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