Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up

Objective, Study Design, Setting, MethodsTo improve our knowledge about head and neck paragangliomas (HN-PGL), the clinical characteristics of all the patients with HN-PGL included in the Spanish Registry were analyzed, as well as the treatment modalities and their outcomes.ResultsA total of 202 pat...

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Autores: Lamas Oliveira, Cristina, Febrero, Beatriz, Casteràs, Anna, Romero Lluch, Ana, Recio Córdova, José María, Ros, Inmaculada, Iglesias, Pedro, Hanzu, Felicia Alexandra, Araujo Castro, Marta, Guerrero Pérez, Fernando, Ares, Jessica, Menéndez, Edelmiro, Paja Fano, Miguel, Álvarez Escolá, Cristina, Librizzi, Soledad, Sánchez Sobrino, Paula, Andrés Petrel, Fernando, Calatayud Gutiérrez, María
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/42650
Acceso en línea:https://doi.org/10.1002/ohn.1012
https://hdl.handle.net/10578/42650
Access Level:acceso embargado
Palabra clave:Active surveillance
Head and neck
Paraganglioma
Succinate dehydrogenase
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spelling Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-UpLamas Oliveira, CristinaFebrero, BeatrizCasteràs, AnnaRomero Lluch, AnaRecio Córdova, José MaríaRos, InmaculadaIglesias, PedroHanzu, Felicia AlexandraAraujo Castro, MartaGuerrero Pérez, FernandoAres, JessicaMenéndez, EdelmiroPaja Fano, MiguelÁlvarez Escolá, CristinaLibrizzi, SoledadSánchez Sobrino, PaulaAndrés Petrel, FernandoCalatayud Gutiérrez, MaríaActive surveillanceHead and neckParagangliomaSuccinate dehydrogenaseObjective, Study Design, Setting, MethodsTo improve our knowledge about head and neck paragangliomas (HN-PGL), the clinical characteristics of all the patients with HN-PGL included in the Spanish Registry were analyzed, as well as the treatment modalities and their outcomes.ResultsA total of 202 patients, 67.8% women, aged 53.1 ± 17.4, with 264 HN-PGL, from 16 Spanish hospitals, were included. Tumors were located in the carotid body in 61%, jugular bulb in 20.5%, tympanic area in 10.2%, and along the vagal nerve in 6.4%. Multiple tumors developed in 20.8% and metastatic disease in 4%. A genetic study was done in 64.4% and showed a pathogenic variant in SDHx in 50%. These patients were younger, with no sex predominance, and had more multiple and metastatic tumors. Tumors were treated by surgery in 134 patients, radiotherapy in 33, and other treatments in 20, and were observed without active treatment in 41 patients, who were older, more often asymptomatic, and had smaller tumors. Tumors treated with radiotherapy were larger and more often in locations other than the carotid body. After a median follow-up of 80 months (interquartile range: 41-136), 6.9% had died; among the survivors, 48.4% were disease-free, 42.1% stable, and 9.4% had progressed. The rate of sequelae was similar among patients submitted to surgery, radiotherapy, or observation. We could not identify any prognostic factor for progression.ConclusionMost HN-PGL are localized slow-growing tumors. Long-term survival is high, even in case of metastasis. Although surgery is the most common treatment, radiotherapy and active surveillance are safe approachesWiley202520252025info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.1002/ohn.1012https://hdl.handle.net/10578/42650reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/embargoedAccessoai:ruidera.uclm.es:10578/426502026-05-27T07:36:41Z
dc.title.none.fl_str_mv Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up
title Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up
spellingShingle Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up
Lamas Oliveira, Cristina
Active surveillance
Head and neck
Paraganglioma
Succinate dehydrogenase
title_short Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up
title_full Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up
title_fullStr Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up
title_full_unstemmed Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up
title_sort Current Management of Head and Neck Paragangliomas: A Multicenter Series With Long-Term Follow-Up
dc.creator.none.fl_str_mv Lamas Oliveira, Cristina
Febrero, Beatriz
Casteràs, Anna
Romero Lluch, Ana
Recio Córdova, José María
Ros, Inmaculada
Iglesias, Pedro
Hanzu, Felicia Alexandra
Araujo Castro, Marta
Guerrero Pérez, Fernando
Ares, Jessica
Menéndez, Edelmiro
Paja Fano, Miguel
Álvarez Escolá, Cristina
Librizzi, Soledad
Sánchez Sobrino, Paula
Andrés Petrel, Fernando
Calatayud Gutiérrez, María
author Lamas Oliveira, Cristina
author_facet Lamas Oliveira, Cristina
Febrero, Beatriz
Casteràs, Anna
Romero Lluch, Ana
Recio Córdova, José María
Ros, Inmaculada
Iglesias, Pedro
Hanzu, Felicia Alexandra
Araujo Castro, Marta
Guerrero Pérez, Fernando
Ares, Jessica
Menéndez, Edelmiro
Paja Fano, Miguel
Álvarez Escolá, Cristina
Librizzi, Soledad
Sánchez Sobrino, Paula
Andrés Petrel, Fernando
Calatayud Gutiérrez, María
author_role author
author2 Febrero, Beatriz
Casteràs, Anna
Romero Lluch, Ana
Recio Córdova, José María
Ros, Inmaculada
Iglesias, Pedro
Hanzu, Felicia Alexandra
Araujo Castro, Marta
Guerrero Pérez, Fernando
Ares, Jessica
Menéndez, Edelmiro
Paja Fano, Miguel
Álvarez Escolá, Cristina
Librizzi, Soledad
Sánchez Sobrino, Paula
Andrés Petrel, Fernando
Calatayud Gutiérrez, María
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Active surveillance
Head and neck
Paraganglioma
Succinate dehydrogenase
topic Active surveillance
Head and neck
Paraganglioma
Succinate dehydrogenase
description Objective, Study Design, Setting, MethodsTo improve our knowledge about head and neck paragangliomas (HN-PGL), the clinical characteristics of all the patients with HN-PGL included in the Spanish Registry were analyzed, as well as the treatment modalities and their outcomes.ResultsA total of 202 patients, 67.8% women, aged 53.1 ± 17.4, with 264 HN-PGL, from 16 Spanish hospitals, were included. Tumors were located in the carotid body in 61%, jugular bulb in 20.5%, tympanic area in 10.2%, and along the vagal nerve in 6.4%. Multiple tumors developed in 20.8% and metastatic disease in 4%. A genetic study was done in 64.4% and showed a pathogenic variant in SDHx in 50%. These patients were younger, with no sex predominance, and had more multiple and metastatic tumors. Tumors were treated by surgery in 134 patients, radiotherapy in 33, and other treatments in 20, and were observed without active treatment in 41 patients, who were older, more often asymptomatic, and had smaller tumors. Tumors treated with radiotherapy were larger and more often in locations other than the carotid body. After a median follow-up of 80 months (interquartile range: 41-136), 6.9% had died; among the survivors, 48.4% were disease-free, 42.1% stable, and 9.4% had progressed. The rate of sequelae was similar among patients submitted to surgery, radiotherapy, or observation. We could not identify any prognostic factor for progression.ConclusionMost HN-PGL are localized slow-growing tumors. Long-term survival is high, even in case of metastasis. Although surgery is the most common treatment, radiotherapy and active surveillance are safe approaches
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1002/ohn.1012
https://hdl.handle.net/10578/42650
url https://doi.org/10.1002/ohn.1012
https://hdl.handle.net/10578/42650
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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