Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response

Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from C...

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Autores: Pinazo, Maria-Jesus, Posada, Elizabeth, Izquierdo Lázaro, Luis, Tàssies Penella, María Dolores, Ferreira Marques, Alexandre, Lazzari, Elisa de, Aldasoro, Edelweiss, Muñoz, José, Abras Feliu, Alba, Tebar, Silvia, Gállego Culleré, M. (Montserrat), Almeida, Igor Correia de, Reverter Calatayud, Juan Carlos, Gascón i Brustenga, Joaquim
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/112005
Acceso en línea:https://hdl.handle.net/2445/112005
Access Level:acceso abierto
Palabra clave:Hemostàsia
Malalties parasitàries
Malaltia de Chagas
Hemostasis
Parasitic diseases
Chagas' disease
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spelling Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. ResponsePinazo, Maria-JesusPosada, ElizabethIzquierdo Lázaro, LuisTàssies Penella, María DoloresFerreira Marques, AlexandreLazzari, Elisa deAldasoro, EdelweissMuñoz, JoséAbras Feliu, AlbaTebar, SilviaGállego Culleré, M. (Montserrat)Almeida, Igor Correia deReverter Calatayud, Juan CarlosGascón i Brustenga, JoaquimHemostàsiaMalalties parasitàriesMalaltia de ChagasHemostasisParasitic diseasesChagas' diseaseThromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endemic areas were classified in two groups: G1, with T.cruzi infection (n = 56); G2, healthy individuals (n = 43). Twenty-four hemostasis factors were measured at baseline. G1 patients treated with benznidazole were followed for 36 months, recording clinical parameters and performance of conventional serology, chemiluminescent enzyme-linked immunosorbent assay (trypomastigote-derived glycosylphosphatidylinositol-anchored mucins), quantitative polymerase chain reaction, and hemostasis tests every 6-month visits. Prothrombin fragment 1+2 (F1+2) and endogenous thrombin potential (ETP) were abnormally expressed in 77% and 50% of infected patients at baseline but returned to and remained at normal levels shortly after treatment in 76% and 96% of cases, respectively. Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment. None of the patients with normal F1+2 values during follow-up had a positive qRT-PCR result, but 3/24 patients (13%) with normal ETP values did. In a percentage of chronic T. cruzi infected patients treated with benznidazole, altered coagulation markers returned into normal levels. F1+2, ETP and PAP could be useful markers for assessing sustained response to benznidazole.Public Library of Science (PLoS)2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/112005Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pntd.0004269PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 1, p. e0004269https://doi.org/10.1371/journal.pntd.0004269cc-by (c) Pinazo, María Jesús et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1120052026-05-29T05:05:01Z
dc.title.none.fl_str_mv Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
title Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
spellingShingle Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
Pinazo, Maria-Jesus
Hemostàsia
Malalties parasitàries
Malaltia de Chagas
Hemostasis
Parasitic diseases
Chagas' disease
title_short Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
title_full Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
title_fullStr Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
title_full_unstemmed Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
title_sort Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
dc.creator.none.fl_str_mv Pinazo, Maria-Jesus
Posada, Elizabeth
Izquierdo Lázaro, Luis
Tàssies Penella, María Dolores
Ferreira Marques, Alexandre
Lazzari, Elisa de
Aldasoro, Edelweiss
Muñoz, José
Abras Feliu, Alba
Tebar, Silvia
Gállego Culleré, M. (Montserrat)
Almeida, Igor Correia de
Reverter Calatayud, Juan Carlos
Gascón i Brustenga, Joaquim
author Pinazo, Maria-Jesus
author_facet Pinazo, Maria-Jesus
Posada, Elizabeth
Izquierdo Lázaro, Luis
Tàssies Penella, María Dolores
Ferreira Marques, Alexandre
Lazzari, Elisa de
Aldasoro, Edelweiss
Muñoz, José
Abras Feliu, Alba
Tebar, Silvia
Gállego Culleré, M. (Montserrat)
Almeida, Igor Correia de
Reverter Calatayud, Juan Carlos
Gascón i Brustenga, Joaquim
author_role author
author2 Posada, Elizabeth
Izquierdo Lázaro, Luis
Tàssies Penella, María Dolores
Ferreira Marques, Alexandre
Lazzari, Elisa de
Aldasoro, Edelweiss
Muñoz, José
Abras Feliu, Alba
Tebar, Silvia
Gállego Culleré, M. (Montserrat)
Almeida, Igor Correia de
Reverter Calatayud, Juan Carlos
Gascón i Brustenga, Joaquim
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hemostàsia
Malalties parasitàries
Malaltia de Chagas
Hemostasis
Parasitic diseases
Chagas' disease
topic Hemostàsia
Malalties parasitàries
Malaltia de Chagas
Hemostasis
Parasitic diseases
Chagas' disease
description Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endemic areas were classified in two groups: G1, with T.cruzi infection (n = 56); G2, healthy individuals (n = 43). Twenty-four hemostasis factors were measured at baseline. G1 patients treated with benznidazole were followed for 36 months, recording clinical parameters and performance of conventional serology, chemiluminescent enzyme-linked immunosorbent assay (trypomastigote-derived glycosylphosphatidylinositol-anchored mucins), quantitative polymerase chain reaction, and hemostasis tests every 6-month visits. Prothrombin fragment 1+2 (F1+2) and endogenous thrombin potential (ETP) were abnormally expressed in 77% and 50% of infected patients at baseline but returned to and remained at normal levels shortly after treatment in 76% and 96% of cases, respectively. Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment. None of the patients with normal F1+2 values during follow-up had a positive qRT-PCR result, but 3/24 patients (13%) with normal ETP values did. In a percentage of chronic T. cruzi infected patients treated with benznidazole, altered coagulation markers returned into normal levels. F1+2, ETP and PAP could be useful markers for assessing sustained response to benznidazole.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/112005
url https://hdl.handle.net/2445/112005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pntd.0004269
PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 1, p. e0004269
https://doi.org/10.1371/journal.pntd.0004269
dc.rights.none.fl_str_mv cc-by (c) Pinazo, María Jesús et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Pinazo, María Jesús et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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