Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)

Fibrosi; Obesitat; Àcid palmític (AP)

Detalles Bibliográficos
Autores: Estévez-Vázquez, Olga, Guo, Feifei, Gómez-Santos, Beatriz, Aspichueta, Patricia, Reissing, Johanna, Pericàs Pulido, Juan Manuel, Ciudin Mihai, Andreea, Benedé-Ubieto, Raquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/7139
Acceso en línea:https://hdl.handle.net/11351/7139
Access Level:acceso abierto
Palabra clave:Esteatosi hepàtica
Àcids grassos saturats - Metabolisme
Ratolins
DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
Other subheadings::Other subheadings::Other subheadings::/metabolism
CHEMICALS AND DRUGS::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Trans Fatty Acids
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática alcohólica
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
COMPUESTOS QUÍMICOS Y DROGAS::lípidos::ácidos grasos::ácidos grasos insaturados::ácidos grasos trans
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
id ES_3fac09da4d492b15f4ec6f828bdf233f
oai_identifier_str oai:scientiasalut.gencat.cat:11351/7139
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
title Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
spellingShingle Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
Estévez-Vázquez, Olga
Esteatosi hepàtica
Àcids grassos saturats - Metabolisme
Ratolins
DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
Other subheadings::Other subheadings::Other subheadings::/metabolism
CHEMICALS AND DRUGS::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Trans Fatty Acids
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática alcohólica
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
COMPUESTOS QUÍMICOS Y DROGAS::lípidos::ácidos grasos::ácidos grasos insaturados::ácidos grasos trans
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
title_short Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
title_full Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
title_fullStr Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
title_full_unstemmed Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
title_sort Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
dc.creator.none.fl_str_mv Estévez-Vázquez, Olga
Guo, Feifei
Gómez-Santos, Beatriz
Aspichueta, Patricia
Reissing, Johanna
Pericàs Pulido, Juan Manuel
Ciudin Mihai, Andreea
Benedé-Ubieto, Raquel
author Estévez-Vázquez, Olga
author_facet Estévez-Vázquez, Olga
Guo, Feifei
Gómez-Santos, Beatriz
Aspichueta, Patricia
Reissing, Johanna
Pericàs Pulido, Juan Manuel
Ciudin Mihai, Andreea
Benedé-Ubieto, Raquel
author_role author
author2 Guo, Feifei
Gómez-Santos, Beatriz
Aspichueta, Patricia
Reissing, Johanna
Pericàs Pulido, Juan Manuel
Ciudin Mihai, Andreea
Benedé-Ubieto, Raquel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Estévez-Vázquez O, Benedé-Ubieto R] Department of Physiology, Genetics and Microbiology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain. Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain. [Guo F] Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain. [Gómez-Santos B] Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, 48940 Leioa, Spain. [Aspichueta P] Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, 48940 Leioa, Spain. Biocruces Health Research Institute, 48903 Barakaldo, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28220 Madrid, Spain. [Reissing J] Department of Internal Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany. [Ciudin A] Servei d’Endocrinologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Pericàs JM] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28220 Madrid, Spain. Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Esteatosi hepàtica
Àcids grassos saturats - Metabolisme
Ratolins
DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
Other subheadings::Other subheadings::Other subheadings::/metabolism
CHEMICALS AND DRUGS::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Trans Fatty Acids
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática alcohólica
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
COMPUESTOS QUÍMICOS Y DROGAS::lípidos::ácidos grasos::ácidos grasos insaturados::ácidos grasos trans
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
topic Esteatosi hepàtica
Àcids grassos saturats - Metabolisme
Ratolins
DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
Other subheadings::Other subheadings::Other subheadings::/metabolism
CHEMICALS AND DRUGS::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Trans Fatty Acids
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática alcohólica
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
COMPUESTOS QUÍMICOS Y DROGAS::lípidos::ácidos grasos::ácidos grasos insaturados::ácidos grasos trans
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
description Fibrosi; Obesitat; Àcid palmític (AP)
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7139
url https://hdl.handle.net/11351/7139
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biomedicines;9(10)
https://doi.org/10.3390/biomedicines9101289
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406663054721024
spelling Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)Estévez-Vázquez, OlgaGuo, FeifeiGómez-Santos, BeatrizAspichueta, PatriciaReissing, JohannaPericàs Pulido, Juan ManuelCiudin Mihai, AndreeaBenedé-Ubieto, RaquelEsteatosi hepàticaÀcids grassos saturats - MetabolismeRatolinsDISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver DiseaseOther subheadings::Other subheadings::Other subheadings::/metabolismCHEMICALS AND DRUGS::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Trans Fatty AcidsOther subheadings::Other subheadings::Other subheadings::/adverse effectsENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática alcohólicaOtros calificadores::Otros calificadores::Otros calificadores::/metabolismoCOMPUESTOS QUÍMICOS Y DROGAS::lípidos::ácidos grasos::ácidos grasos insaturados::ácidos grasos transOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosFibrosi; Obesitat; Àcid palmític (AP)Fibrosis; Obesidad; Ácido palmítico (AP)Fibrosis; Obesity; Palmitic acid (PA)Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD.This work was supported by the MINECO Retos SAF2016-78711, SAF2017-87919-R, PID2020-117827RB-IOO, PID2020-117941RB-IOO, EXOHEP-CM S2017/BMD-3727, NanoLiver-CM Y2018/NMT-4949, AMMF 2018/117, COST Action CA17112 and UCM-25/2019, German Research Foundation (SFB/TRR57/P04, SFB 1382-403224013/A02). F.J.C. and Y.A.N. are Ramón y Cajal Researchers RYC-2014-15242 and RYC-2015-17438. F.J.C. is a Gilead Liver Research Scholar. The research group belongs to the validated Research Groups Ref. 970935 ¨Liver Pathophysiology¨, 920631 ¨Lymphocyte immunobiology¨, 920361 “Inmunogenética e6937 inmunología de las mucosas” and IBL-6 (imas12-associated). O.E.-V. is supported by Beca FPI (associated with MINECO SAF2017-87919R), C.-S.G. by Atracción de Talento 2019-T1/BMD-1331 and R.B.-U. by Contratos predoctorales de personal investigador en formación UCM-Banco Santander (CT63/19). F.G. is a Chinese Scholarship Council (CSC) fellow. T.B. is supported by the German Research Foundation SFB 1382-403224013/B07, and P.A. by Ayudas para apoyar grupos de investigación del sistema Universitario Vasco (IT971-16) and MCIU/AEI/FEDER, UE (RTI2018-095134-B-100).MDPIInstitut Català de la Salut[Estévez-Vázquez O, Benedé-Ubieto R] Department of Physiology, Genetics and Microbiology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain. Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain. [Guo F] Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain. [Gómez-Santos B] Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, 48940 Leioa, Spain. [Aspichueta P] Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, 48940 Leioa, Spain. Biocruces Health Research Institute, 48903 Barakaldo, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28220 Madrid, Spain. [Reissing J] Department of Internal Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany. [Ciudin A] Servei d’Endocrinologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Pericàs JM] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28220 Madrid, Spain. Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/7139Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésBiomedicines;9(10)https://doi.org/10.3390/biomedicines9101289Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/71392026-06-12T09:38:37Z
score 15.811543

Similares en LA Referencia