Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus

Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transie...

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Autores: Ontanilla-Clavijo, Guillermo, Praena Segovia, Julia, Giráldez Gallego, Álvaro, Cordero Matia, María Elisa, Sousa Martín, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/158771
Acceso en línea:https://hdl.handle.net/11441/158771
https://doi.org/10.17235/reed.2017.4072/2015
Access Level:acceso abierto
Palabra clave:Epstein-Barr virus
Acute hepatitis
Hemolytic anemia
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spelling Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virusOntanilla-Clavijo, GuillermoPraena Segovia, JuliaGiráldez Gallego, ÁlvaroCordero Matia, María ElisaSousa Martín, José ManuelEpstein-Barr virusAcute hepatitisHemolytic anemiaEpstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation.Aran Ediciones S.A.MedicinaCTS203 : Estudio de las enfermedades infecciosas2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/158771https://doi.org/10.17235/reed.2017.4072/2015reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésRevista Española de Enfermedades Digestivas, 109 (5), 388-390.https://www.reed.es/severe-acute-hepatitis-and-cold-agglutinin-related-hemolytic-anemia-secondary-to-prime-infection-with-epstein-barr-virus942info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1587712026-06-17T12:51:07Z
dc.title.none.fl_str_mv Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
title Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
spellingShingle Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
Ontanilla-Clavijo, Guillermo
Epstein-Barr virus
Acute hepatitis
Hemolytic anemia
title_short Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
title_full Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
title_fullStr Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
title_full_unstemmed Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
title_sort Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
dc.creator.none.fl_str_mv Ontanilla-Clavijo, Guillermo
Praena Segovia, Julia
Giráldez Gallego, Álvaro
Cordero Matia, María Elisa
Sousa Martín, José Manuel
author Ontanilla-Clavijo, Guillermo
author_facet Ontanilla-Clavijo, Guillermo
Praena Segovia, Julia
Giráldez Gallego, Álvaro
Cordero Matia, María Elisa
Sousa Martín, José Manuel
author_role author
author2 Praena Segovia, Julia
Giráldez Gallego, Álvaro
Cordero Matia, María Elisa
Sousa Martín, José Manuel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Medicina
CTS203 : Estudio de las enfermedades infecciosas
dc.subject.none.fl_str_mv Epstein-Barr virus
Acute hepatitis
Hemolytic anemia
topic Epstein-Barr virus
Acute hepatitis
Hemolytic anemia
description Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/158771
https://doi.org/10.17235/reed.2017.4072/2015
url https://hdl.handle.net/11441/158771
https://doi.org/10.17235/reed.2017.4072/2015
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Revista Española de Enfermedades Digestivas, 109 (5), 388-390.
https://www.reed.es/severe-acute-hepatitis-and-cold-agglutinin-related-hemolytic-anemia-secondary-to-prime-infection-with-epstein-barr-virus942
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Aran Ediciones S.A.
publisher.none.fl_str_mv Aran Ediciones S.A.
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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