The Barcelona Brain Health Initiative: Cohort description and first follow-up

The Barcelona Brain Health Initiative is a longitudinal cohort study that began in 2017 and aims to understand and characterize the determinants of brain health maintenance in middle aged adults. A cohort of 4686 individuals between the ages of 40 and 65 years free from any neurological or psychiatr...

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Detalhes bibliográficos
Autores: Cattaneo, Gabriele, Bartrés Faz, David, Morris, Timothy Peter, Solana Sánchez, Javier, Macià Bros, Dídac, Tormos, José María, Pascual Leone, Álvaro, 1961-
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176811
Acesso em linha:https://hdl.handle.net/2445/176811
Access Level:acceso abierto
Palavra-chave:Salut mental
Condició física
Estils de vida
Mental health
Physical fitness
Lifestyles
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spelling The Barcelona Brain Health Initiative: Cohort description and first follow-upCattaneo, GabrieleBartrés Faz, DavidMorris, Timothy PeterSolana Sánchez, JavierMacià Bros, DídacTormos, José MaríaPascual Leone, Álvaro, 1961-Salut mentalCondició físicaEstils de vidaMental healthPhysical fitnessLifestylesThe Barcelona Brain Health Initiative is a longitudinal cohort study that began in 2017 and aims to understand and characterize the determinants of brain health maintenance in middle aged adults. A cohort of 4686 individuals between the ages of 40 and 65 years free from any neurological or psychiatric diseases was established, and we collected extensive demographic, socio-economic information along with measures of self-perceived health and lifestyles (general health, physical activity, cognitive activity, socialization, sleep, nutrition and vital plan). Here we report on the baseline characteristics of the participants, and the results of the one-year follow-up evaluation. Participants were mainly women, highly educated, and with better lifestyles compared with the general population. After one year 60% of participants completed the one-year follow-up, and these were older, with higher educational level and with better lifestyles in some domains. In the absence of any specific interventions to-date, these participants showed small improvements in physical activity and sleep, but decreased adherence to a Mediterranean diet. These changes were negatively associated with baseline scores, and poorer habits at baseline were predictive of an improvement in lifestyle domains. Of the 2353 participants who completed the one-year follow-up, 73 had been diagnosed with new neurological and neuropsychiatric diseases. Changes in vital plan at follow-up, as well as gender, sleep quality and sense of coherence at baseline were shown to be significant risk factors for the onset of these diagnoses. Notably, gender risk factor decreased in importance as we adjusted by sleep habits, suggesting its potential mediator effects. These findings stress the importance of healthy lifestyles in sustaining brain health, and illustrate the individual benefit that can be derived from participation in longitudinal observational studies. Modifiable lifestyles, specifically quality of sleep, may partially mediate the effect of other risk factors in the development of some neuropsychiatric conditions.Public Library of Science (PLoS)2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176811Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0228754PLoS One, 2020, vol. 15, num. 2, p. e0228754https://doi.org/10.1371/journal.pone.0228754cc-by (c) Cattaneo, Gabriele et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1768112026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Barcelona Brain Health Initiative: Cohort description and first follow-up
title The Barcelona Brain Health Initiative: Cohort description and first follow-up
spellingShingle The Barcelona Brain Health Initiative: Cohort description and first follow-up
Cattaneo, Gabriele
Salut mental
Condició física
Estils de vida
Mental health
Physical fitness
Lifestyles
title_short The Barcelona Brain Health Initiative: Cohort description and first follow-up
title_full The Barcelona Brain Health Initiative: Cohort description and first follow-up
title_fullStr The Barcelona Brain Health Initiative: Cohort description and first follow-up
title_full_unstemmed The Barcelona Brain Health Initiative: Cohort description and first follow-up
title_sort The Barcelona Brain Health Initiative: Cohort description and first follow-up
dc.creator.none.fl_str_mv Cattaneo, Gabriele
Bartrés Faz, David
Morris, Timothy Peter
Solana Sánchez, Javier
Macià Bros, Dídac
Tormos, José María
Pascual Leone, Álvaro, 1961-
author Cattaneo, Gabriele
author_facet Cattaneo, Gabriele
Bartrés Faz, David
Morris, Timothy Peter
Solana Sánchez, Javier
Macià Bros, Dídac
Tormos, José María
Pascual Leone, Álvaro, 1961-
author_role author
author2 Bartrés Faz, David
Morris, Timothy Peter
Solana Sánchez, Javier
Macià Bros, Dídac
Tormos, José María
Pascual Leone, Álvaro, 1961-
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Salut mental
Condició física
Estils de vida
Mental health
Physical fitness
Lifestyles
topic Salut mental
Condició física
Estils de vida
Mental health
Physical fitness
Lifestyles
description The Barcelona Brain Health Initiative is a longitudinal cohort study that began in 2017 and aims to understand and characterize the determinants of brain health maintenance in middle aged adults. A cohort of 4686 individuals between the ages of 40 and 65 years free from any neurological or psychiatric diseases was established, and we collected extensive demographic, socio-economic information along with measures of self-perceived health and lifestyles (general health, physical activity, cognitive activity, socialization, sleep, nutrition and vital plan). Here we report on the baseline characteristics of the participants, and the results of the one-year follow-up evaluation. Participants were mainly women, highly educated, and with better lifestyles compared with the general population. After one year 60% of participants completed the one-year follow-up, and these were older, with higher educational level and with better lifestyles in some domains. In the absence of any specific interventions to-date, these participants showed small improvements in physical activity and sleep, but decreased adherence to a Mediterranean diet. These changes were negatively associated with baseline scores, and poorer habits at baseline were predictive of an improvement in lifestyle domains. Of the 2353 participants who completed the one-year follow-up, 73 had been diagnosed with new neurological and neuropsychiatric diseases. Changes in vital plan at follow-up, as well as gender, sleep quality and sense of coherence at baseline were shown to be significant risk factors for the onset of these diagnoses. Notably, gender risk factor decreased in importance as we adjusted by sleep habits, suggesting its potential mediator effects. These findings stress the importance of healthy lifestyles in sustaining brain health, and illustrate the individual benefit that can be derived from participation in longitudinal observational studies. Modifiable lifestyles, specifically quality of sleep, may partially mediate the effect of other risk factors in the development of some neuropsychiatric conditions.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176811
url https://hdl.handle.net/2445/176811
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0228754
PLoS One, 2020, vol. 15, num. 2, p. e0228754
https://doi.org/10.1371/journal.pone.0228754
dc.rights.none.fl_str_mv cc-by (c) Cattaneo, Gabriele et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Cattaneo, Gabriele et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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