Endogenous purine and pyrimidine derivative excretion in pregnant sows

The present experiment was camed out to study the endogenous losses of purine and pyrimidine derivatives from pregnant sows. Three pregnant and three non-pregnant Large White x Landrace sows were fed on a purine-free diet composed of starch, glucose, sucrose and vegetable oil, with casein as the pro...

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Autores: Martin-Orúe, S. M., Balcells Terés, Joaquim, Guada, J. A., Castrillo, C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1995
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/64892
Acceso en línea:https://doi.org/10.1079/BJN19950040
http://hdl.handle.net/10459.1/64892
Access Level:acceso abierto
Palabra clave:Purine derivatives
Pseudouridine
Pregnancy
Sow
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spelling Endogenous purine and pyrimidine derivative excretion in pregnant sowsMartin-Orúe, S. M.Balcells Terés, JoaquimGuada, J. A.Castrillo, C.Purine derivativesPseudouridinePregnancySowThe present experiment was camed out to study the endogenous losses of purine and pyrimidine derivatives from pregnant sows. Three pregnant and three non-pregnant Large White x Landrace sows were fed on a purine-free diet composed of starch, glucose, sucrose and vegetable oil, with casein as the protein source. The experiment began, for the six animals, after diagnosis of pregnancy and was divided into six 12 d periods. Urine was collected during the Arst 3 d of each experimental period by means of a urethral catheter for determination of allantoin, uric acid, xanthine, hypoxanthine and pseudouridine concentrations. In the absence of dietary nucleic acids (NA), allantoin and, as a consequence, excretion of total purine derivatives (PD) decreased significantly to a constant value (128.3 (SE 7.07) ,umol/kg metabolic live weight (W"75) per d), an amount assumed to represent endogenous excretion. Excretion of uric acid (38.7 (SE 2-15) mollkg W0'p7e5r d), hypoxanthine (21.0 (SE 2.58) ymollkg W'75 per d) and xanthine (11-2 (SE 0.83) pmol/kg W@" per d) were not affected by the experimental treatment, although there was a significant decrease in hypoxanthine excretion in pregnant sows (from 25.5 to 5.2 pnol/kg W@75 per d) compared with nowpregnant sows (from 26.7 to 44%/rmol/kg W@75p er d). Creatinine excretion was not affected by pregnancy and was used as an internal urinary marker. Purine excretion, either expressed as pmol/kg WoT5 per d or as the ratio PD:creatinine, was not affected by experimental treatment, although an apparent increase in pseudouridine excretion, a modified unsalvageable catabolite of RNA-pyrimidine, was found in late pregnancy (3.6 v. 5.2 mo1/100 mol creatinine in non-pregnant sows compared with pregnant sows at 102 d collection).This work has been supported by the CICYT Project Gan 91-1050-C02-01Cambridge University Press201820181995info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1079/BJN19950040http://hdl.handle.net/10459.1/64892http://hdl.handle.net/10459.1/64892reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.1079/BJN19950040British Journal of Nutrition,1995, vol. 73, p. 375-385(c) Cambridge University Press, 1995info:eu-repo/semantics/openAccessoai:recercat.cat:10459.1/648922026-05-29T05:05:01Z
dc.title.none.fl_str_mv Endogenous purine and pyrimidine derivative excretion in pregnant sows
title Endogenous purine and pyrimidine derivative excretion in pregnant sows
spellingShingle Endogenous purine and pyrimidine derivative excretion in pregnant sows
Martin-Orúe, S. M.
Purine derivatives
Pseudouridine
Pregnancy
Sow
title_short Endogenous purine and pyrimidine derivative excretion in pregnant sows
title_full Endogenous purine and pyrimidine derivative excretion in pregnant sows
title_fullStr Endogenous purine and pyrimidine derivative excretion in pregnant sows
title_full_unstemmed Endogenous purine and pyrimidine derivative excretion in pregnant sows
title_sort Endogenous purine and pyrimidine derivative excretion in pregnant sows
dc.creator.none.fl_str_mv Martin-Orúe, S. M.
Balcells Terés, Joaquim
Guada, J. A.
Castrillo, C.
author Martin-Orúe, S. M.
author_facet Martin-Orúe, S. M.
Balcells Terés, Joaquim
Guada, J. A.
Castrillo, C.
author_role author
author2 Balcells Terés, Joaquim
Guada, J. A.
Castrillo, C.
author2_role author
author
author
dc.subject.none.fl_str_mv Purine derivatives
Pseudouridine
Pregnancy
Sow
topic Purine derivatives
Pseudouridine
Pregnancy
Sow
description The present experiment was camed out to study the endogenous losses of purine and pyrimidine derivatives from pregnant sows. Three pregnant and three non-pregnant Large White x Landrace sows were fed on a purine-free diet composed of starch, glucose, sucrose and vegetable oil, with casein as the protein source. The experiment began, for the six animals, after diagnosis of pregnancy and was divided into six 12 d periods. Urine was collected during the Arst 3 d of each experimental period by means of a urethral catheter for determination of allantoin, uric acid, xanthine, hypoxanthine and pseudouridine concentrations. In the absence of dietary nucleic acids (NA), allantoin and, as a consequence, excretion of total purine derivatives (PD) decreased significantly to a constant value (128.3 (SE 7.07) ,umol/kg metabolic live weight (W"75) per d), an amount assumed to represent endogenous excretion. Excretion of uric acid (38.7 (SE 2-15) mollkg W0'p7e5r d), hypoxanthine (21.0 (SE 2.58) ymollkg W'75 per d) and xanthine (11-2 (SE 0.83) pmol/kg W@" per d) were not affected by the experimental treatment, although there was a significant decrease in hypoxanthine excretion in pregnant sows (from 25.5 to 5.2 pnol/kg W@75 per d) compared with nowpregnant sows (from 26.7 to 44%/rmol/kg W@75p er d). Creatinine excretion was not affected by pregnancy and was used as an internal urinary marker. Purine excretion, either expressed as pmol/kg WoT5 per d or as the ratio PD:creatinine, was not affected by experimental treatment, although an apparent increase in pseudouridine excretion, a modified unsalvageable catabolite of RNA-pyrimidine, was found in late pregnancy (3.6 v. 5.2 mo1/100 mol creatinine in non-pregnant sows compared with pregnant sows at 102 d collection).
publishDate 1995
dc.date.none.fl_str_mv 1995
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1079/BJN19950040
http://hdl.handle.net/10459.1/64892
http://hdl.handle.net/10459.1/64892
url https://doi.org/10.1079/BJN19950040
http://hdl.handle.net/10459.1/64892
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1079/BJN19950040
British Journal of Nutrition,1995, vol. 73, p. 375-385
dc.rights.none.fl_str_mv (c) Cambridge University Press, 1995
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Cambridge University Press, 1995
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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