Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells

T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last f...

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Detalles Bibliográficos
Autores: Angelats Canals, Edgar, Santamaria Vilanova, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214354
Acceso en línea:https://hdl.handle.net/2445/214354
Access Level:acceso abierto
Palabra clave:Cèl·lules T
Nanomedicina
T cells
Nanomedicine
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spelling Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cellsAngelats Canals, EdgarSantamaria Vilanova, PereCèl·lules TNanomedicinaT cellsNanomedicineT Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny.Frontiers2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/214354Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1267697Frontiers In Immunology, 2023, vol. 14https://doi.org/10.3389/fimmu.2023.1267697cc by (c) Angelats Canals, Edgar et al, 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2143542026-05-29T05:05:01Z
dc.title.none.fl_str_mv Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
title Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
spellingShingle Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
Angelats Canals, Edgar
Cèl·lules T
Nanomedicina
T cells
Nanomedicine
title_short Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
title_full Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
title_fullStr Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
title_full_unstemmed Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
title_sort Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
dc.creator.none.fl_str_mv Angelats Canals, Edgar
Santamaria Vilanova, Pere
author Angelats Canals, Edgar
author_facet Angelats Canals, Edgar
Santamaria Vilanova, Pere
author_role author
author2 Santamaria Vilanova, Pere
author2_role author
dc.subject.none.fl_str_mv Cèl·lules T
Nanomedicina
T cells
Nanomedicine
topic Cèl·lules T
Nanomedicina
T cells
Nanomedicine
description T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214354
url https://hdl.handle.net/2445/214354
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1267697
Frontiers In Immunology, 2023, vol. 14
https://doi.org/10.3389/fimmu.2023.1267697
dc.rights.none.fl_str_mv cc by (c) Angelats Canals, Edgar et al, 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Angelats Canals, Edgar et al, 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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