A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries

Background: Intravascular lithotripsy (IVL) has demonstrated effectiveness in the treatment of calcified lesions in selected patients with stable coronary disease. Objectives: The authors sought to assess the performance of coronary IVL in calcified coronary lesions in a real-life, all comers, setti...

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Autores: Rodriguez-Leor, Oriol|||0000-0003-2657-5657, Cid-Alvarez, Ana Belen, Lopez-Benito, Maria, Gonzalo, Nieves|||0000-0003-3827-945X, Vilalta, Victoria|||0000-0003-1767-5963, Diarte de Miguel, Jose Antonio, Fernandez López, Leticia, Jurado-Roman, Alfonso, Diego, Alejandro, Oteo, Juan F.|||0000-0002-2641-4135, Cuellas, Carlos, Trillo, Ramiro, Travieso, Alejandro|||0000-0003-3013-2592, Alfonso, Fernando|||0000-0002-7480-2511, Carrillo, Xavier|||0000-0001-6691-8859, Vegas-Valle, José Miguel, Cortes-Villar, Carlos|||0000-0002-9332-4236, Pascual, Isaac|||0000-0001-5433-1364, Muñoz Camacho, Juan Francisco, Flores, Xacobe, Vera-Vera, Silvio|||0000-0002-3165-6948, Moreu, Jose, Barreira de Sousa, Gilles, Martí, David, Jimenez-Mazuecos, Jesus, Fuertes, Monica, Ocaranza, Raymundo, de la Torre Hernandez, Jose Maria|||0000-0003-4570-8902, Lozano, Fernando|||0000-0001-9513-0614, Solana Martinez, Santiago G., Gomez Lara, Josep|||0000-0001-9731-4767, Perez de Prado, Armando|||0000-0003-3283-0597
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:310578
Acceso en línea:https://ddd.uab.cat/record/310578
https://dx.doi.org/urn:doi:10.1016/j.jcin.2023.12.018
Access Level:acceso abierto
Palabra clave:Acute coronary syndrome
Coronary artery calcification
Intravascular lithotripsy
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spelling A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary ArteriesThe REPLICA-EPIC18 StudyRodriguez-Leor, Oriol|||0000-0003-2657-5657Cid-Alvarez, Ana BelenLopez-Benito, MariaGonzalo, Nieves|||0000-0003-3827-945XVilalta, Victoria|||0000-0003-1767-5963Diarte de Miguel, Jose AntonioFernandez López, LeticiaJurado-Roman, AlfonsoDiego, AlejandroOteo, Juan F.|||0000-0002-2641-4135Cuellas, CarlosTrillo, RamiroTravieso, Alejandro|||0000-0003-3013-2592Alfonso, Fernando|||0000-0002-7480-2511Carrillo, Xavier|||0000-0001-6691-8859Vegas-Valle, José MiguelCortes-Villar, Carlos|||0000-0002-9332-4236Pascual, Isaac|||0000-0001-5433-1364Muñoz Camacho, Juan FranciscoFlores, XacobeVera-Vera, Silvio|||0000-0002-3165-6948Moreu, JoseBarreira de Sousa, GillesMartí, DavidJimenez-Mazuecos, JesusFuertes, MonicaOcaranza, Raymundode la Torre Hernandez, Jose Maria|||0000-0003-4570-8902Lozano, Fernando|||0000-0001-9513-0614Solana Martinez, Santiago G.Gomez Lara, Josep|||0000-0001-9731-4767Perez de Prado, Armando|||0000-0003-3283-0597Acute coronary syndromeCoronary artery calcificationIntravascular lithotripsyBackground: Intravascular lithotripsy (IVL) has demonstrated effectiveness in the treatment of calcified lesions in selected patients with stable coronary disease. Objectives: The authors sought to assess the performance of coronary IVL in calcified coronary lesions in a real-life, all comers, setting. Methods: The REPLICA-EPIC18 study prospectively enrolled consecutive patients treated with IVL in 26 centers in Spain. An independent core laboratory performed the angiographic analysis and event adjudication. The primary effectiveness endpoint assessed procedural success (successful IVL delivery, final diameter stenosis <20%, and absence of in-hospital major adverse cardiovascular events [MACE]). The primary safety endpoint measured freedom from MACE at 30 days. A predefined substudy compared outcomes between acute coronary syndrome (ACS) and chronic coronary syndrome (CCS) patients. Results: A total of 426 patients (456 lesions) were included, 63% of the patients presenting with ACS. IVL delivery was successful in 99% of cases. Before IVL, 49% of lesions were considered undilatable. The primary effectiveness endpoint was achieved in 66% of patients, with similar rates among CCS patients (68%) and ACS patients (65%). Likewise, there were no significant differences in angiographic success after IVL between CCS and ACS patients. The rate of MACE at 30 days (primary safety endpoint) was 3% (1% in CCS and 5% in ACS patients [P = 0.073]). Conclusions: Coronary IVL proved to be a feasible and safe procedure in a "real-life" setting, effectively facilitating stent implantation in severely calcified lesions. Patients with ACS on admission showed similar angiographic success rates but showed a trend toward higher 30-day MACE compared with patients with CCS. (REPLICA-EPIC18 study [Registry of Coronary Lithotripsy in Spain]; NCT04298307).REPLICA-EPIC18 InvestigatorsUniversitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/310578https://dx.doi.org/urn:doi:10.1016/j.jcin.2023.12.018reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3105782026-06-06T12:50:31Z
dc.title.none.fl_str_mv A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
The REPLICA-EPIC18 Study
title A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
spellingShingle A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
Rodriguez-Leor, Oriol|||0000-0003-2657-5657
Acute coronary syndrome
Coronary artery calcification
Intravascular lithotripsy
title_short A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
title_full A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
title_fullStr A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
title_full_unstemmed A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
title_sort A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
dc.creator.none.fl_str_mv Rodriguez-Leor, Oriol|||0000-0003-2657-5657
Cid-Alvarez, Ana Belen
Lopez-Benito, Maria
Gonzalo, Nieves|||0000-0003-3827-945X
Vilalta, Victoria|||0000-0003-1767-5963
Diarte de Miguel, Jose Antonio
Fernandez López, Leticia
Jurado-Roman, Alfonso
Diego, Alejandro
Oteo, Juan F.|||0000-0002-2641-4135
Cuellas, Carlos
Trillo, Ramiro
Travieso, Alejandro|||0000-0003-3013-2592
Alfonso, Fernando|||0000-0002-7480-2511
Carrillo, Xavier|||0000-0001-6691-8859
Vegas-Valle, José Miguel
Cortes-Villar, Carlos|||0000-0002-9332-4236
Pascual, Isaac|||0000-0001-5433-1364
Muñoz Camacho, Juan Francisco
Flores, Xacobe
Vera-Vera, Silvio|||0000-0002-3165-6948
Moreu, Jose
Barreira de Sousa, Gilles
Martí, David
Jimenez-Mazuecos, Jesus
Fuertes, Monica
Ocaranza, Raymundo
de la Torre Hernandez, Jose Maria|||0000-0003-4570-8902
Lozano, Fernando|||0000-0001-9513-0614
Solana Martinez, Santiago G.
Gomez Lara, Josep|||0000-0001-9731-4767
Perez de Prado, Armando|||0000-0003-3283-0597
author Rodriguez-Leor, Oriol|||0000-0003-2657-5657
author_facet Rodriguez-Leor, Oriol|||0000-0003-2657-5657
Cid-Alvarez, Ana Belen
Lopez-Benito, Maria
Gonzalo, Nieves|||0000-0003-3827-945X
Vilalta, Victoria|||0000-0003-1767-5963
Diarte de Miguel, Jose Antonio
Fernandez López, Leticia
Jurado-Roman, Alfonso
Diego, Alejandro
Oteo, Juan F.|||0000-0002-2641-4135
Cuellas, Carlos
Trillo, Ramiro
Travieso, Alejandro|||0000-0003-3013-2592
Alfonso, Fernando|||0000-0002-7480-2511
Carrillo, Xavier|||0000-0001-6691-8859
Vegas-Valle, José Miguel
Cortes-Villar, Carlos|||0000-0002-9332-4236
Pascual, Isaac|||0000-0001-5433-1364
Muñoz Camacho, Juan Francisco
Flores, Xacobe
Vera-Vera, Silvio|||0000-0002-3165-6948
Moreu, Jose
Barreira de Sousa, Gilles
Martí, David
Jimenez-Mazuecos, Jesus
Fuertes, Monica
Ocaranza, Raymundo
de la Torre Hernandez, Jose Maria|||0000-0003-4570-8902
Lozano, Fernando|||0000-0001-9513-0614
Solana Martinez, Santiago G.
Gomez Lara, Josep|||0000-0001-9731-4767
Perez de Prado, Armando|||0000-0003-3283-0597
author_role author
author2 Cid-Alvarez, Ana Belen
Lopez-Benito, Maria
Gonzalo, Nieves|||0000-0003-3827-945X
Vilalta, Victoria|||0000-0003-1767-5963
Diarte de Miguel, Jose Antonio
Fernandez López, Leticia
Jurado-Roman, Alfonso
Diego, Alejandro
Oteo, Juan F.|||0000-0002-2641-4135
Cuellas, Carlos
Trillo, Ramiro
Travieso, Alejandro|||0000-0003-3013-2592
Alfonso, Fernando|||0000-0002-7480-2511
Carrillo, Xavier|||0000-0001-6691-8859
Vegas-Valle, José Miguel
Cortes-Villar, Carlos|||0000-0002-9332-4236
Pascual, Isaac|||0000-0001-5433-1364
Muñoz Camacho, Juan Francisco
Flores, Xacobe
Vera-Vera, Silvio|||0000-0002-3165-6948
Moreu, Jose
Barreira de Sousa, Gilles
Martí, David
Jimenez-Mazuecos, Jesus
Fuertes, Monica
Ocaranza, Raymundo
de la Torre Hernandez, Jose Maria|||0000-0003-4570-8902
Lozano, Fernando|||0000-0001-9513-0614
Solana Martinez, Santiago G.
Gomez Lara, Josep|||0000-0001-9731-4767
Perez de Prado, Armando|||0000-0003-3283-0597
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv REPLICA-EPIC18 Investigators
Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Acute coronary syndrome
Coronary artery calcification
Intravascular lithotripsy
topic Acute coronary syndrome
Coronary artery calcification
Intravascular lithotripsy
description Background: Intravascular lithotripsy (IVL) has demonstrated effectiveness in the treatment of calcified lesions in selected patients with stable coronary disease. Objectives: The authors sought to assess the performance of coronary IVL in calcified coronary lesions in a real-life, all comers, setting. Methods: The REPLICA-EPIC18 study prospectively enrolled consecutive patients treated with IVL in 26 centers in Spain. An independent core laboratory performed the angiographic analysis and event adjudication. The primary effectiveness endpoint assessed procedural success (successful IVL delivery, final diameter stenosis <20%, and absence of in-hospital major adverse cardiovascular events [MACE]). The primary safety endpoint measured freedom from MACE at 30 days. A predefined substudy compared outcomes between acute coronary syndrome (ACS) and chronic coronary syndrome (CCS) patients. Results: A total of 426 patients (456 lesions) were included, 63% of the patients presenting with ACS. IVL delivery was successful in 99% of cases. Before IVL, 49% of lesions were considered undilatable. The primary effectiveness endpoint was achieved in 66% of patients, with similar rates among CCS patients (68%) and ACS patients (65%). Likewise, there were no significant differences in angiographic success after IVL between CCS and ACS patients. The rate of MACE at 30 days (primary safety endpoint) was 3% (1% in CCS and 5% in ACS patients [P = 0.073]). Conclusions: Coronary IVL proved to be a feasible and safe procedure in a "real-life" setting, effectively facilitating stent implantation in severely calcified lesions. Patients with ACS on admission showed similar angiographic success rates but showed a trend toward higher 30-day MACE compared with patients with CCS. (REPLICA-EPIC18 study [Registry of Coronary Lithotripsy in Spain]; NCT04298307).
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/310578
https://dx.doi.org/urn:doi:10.1016/j.jcin.2023.12.018
url https://ddd.uab.cat/record/310578
https://dx.doi.org/urn:doi:10.1016/j.jcin.2023.12.018
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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