Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients
Background and study aims Effective bowel cleansing is critical for detecting lesions during colonoscopy, highlighting the importance of bowel preparations. 1L polyethylene glycol (PEG) + ascorbate (Asc) is the only recommended 1L PEG product in Europe and the United States. Its efficacy was demonst...
| Autores: | , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/60019 |
| Acceso en línea: | http://hdl.handle.net/10230/60019 http://dx.doi.org/10.1055/a-2125-0025 |
| Access Level: | acceso abierto |
| Palabra clave: | Colonoscopy NER1006 Plenvu Polyethylene glycol Bowel preparation |
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Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patientsLópez-Jamar, José Miguel EstebanGorjao, RicardoCotter, JoséLorenzo-Zúñiga García, VicentePantaleón Sánchez, Miguel ÁngelCarral Martínez, DavidSábado, FernandoPérez Arellano, ElenaGómez Rodríguez, Blas JoséLópez Cano, AntonioMachlab, Salvador TarekArieira, CátiaAkriche, FatmaTurbí Disla, CarmenRodriguez Muñoz, SarbelioColonoscopyNER1006PlenvuPolyethylene glycolBowel preparationBackground and study aims Effective bowel cleansing is critical for detecting lesions during colonoscopy, highlighting the importance of bowel preparations. 1L polyethylene glycol (PEG) + ascorbate (Asc) is the only recommended 1L PEG product in Europe and the United States. Its efficacy was demonstrated in large-scale controlled trials and confirmed in smaller-scale real-world studies. However, no large-scale real-world data exist. Patients and methods This observational, retrospective, multicenter study, used outpatient follow-up data from medical records from 10 centers in Spain and two in Portugal. Outpatients aged ≥18 years using 1L PEG + Asc as bowel preparation were included. The main outcome measures were overall adequate colon cleansing (Boston Bowel Preparation Scale [BBPS] score ≥6 with BBPS score ≥2 in each segment) and high-quality cleansing of the right colon (BBPS score=3). Results Data from 13169 eligible patients were included. Overall cleansing success was achieved in 89.3% (95%CI 88.7%-89.8%) and high-quality cleansing in the right colon in 49.3% (95%CI 48.4%-50.2%) of patients. For the overnight split-dose and same-day regimens, overall adequate quality cleansing success rate was 94.7% and 86.7% ( P <0.0001) and high-quality cleansing of the right colon rate was 65.4% and 41.4% ( P <0.0001), respectively. Colonoscopy was completed in 97.3% of patients, with non-completion due to poor preparation in only 0.8%; 2.3% of patients experienced at least one adverse event (AE). Conclusions This large-scale, real-world study demonstrates the effectiveness of 1L PEG + Asc in the total and right colon, with a low percentage of patients with AEs in routine clinical practice.Georg Thieme Verlag KG202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60019http://dx.doi.org/10.1055/a-2125-0025reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEndosc Int Open. 2023 Aug 16;11(8):E785-93© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/600192026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients |
| title |
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients |
| spellingShingle |
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients López-Jamar, José Miguel Esteban Colonoscopy NER1006 Plenvu Polyethylene glycol Bowel preparation |
| title_short |
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients |
| title_full |
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients |
| title_fullStr |
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients |
| title_full_unstemmed |
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients |
| title_sort |
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients |
| dc.creator.none.fl_str_mv |
López-Jamar, José Miguel Esteban Gorjao, Ricardo Cotter, José Lorenzo-Zúñiga García, Vicente Pantaleón Sánchez, Miguel Ángel Carral Martínez, David Sábado, Fernando Pérez Arellano, Elena Gómez Rodríguez, Blas José López Cano, Antonio Machlab, Salvador Tarek Arieira, Cátia Akriche, Fatma Turbí Disla, Carmen Rodriguez Muñoz, Sarbelio |
| author |
López-Jamar, José Miguel Esteban |
| author_facet |
López-Jamar, José Miguel Esteban Gorjao, Ricardo Cotter, José Lorenzo-Zúñiga García, Vicente Pantaleón Sánchez, Miguel Ángel Carral Martínez, David Sábado, Fernando Pérez Arellano, Elena Gómez Rodríguez, Blas José López Cano, Antonio Machlab, Salvador Tarek Arieira, Cátia Akriche, Fatma Turbí Disla, Carmen Rodriguez Muñoz, Sarbelio |
| author_role |
author |
| author2 |
Gorjao, Ricardo Cotter, José Lorenzo-Zúñiga García, Vicente Pantaleón Sánchez, Miguel Ángel Carral Martínez, David Sábado, Fernando Pérez Arellano, Elena Gómez Rodríguez, Blas José López Cano, Antonio Machlab, Salvador Tarek Arieira, Cátia Akriche, Fatma Turbí Disla, Carmen Rodriguez Muñoz, Sarbelio |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Colonoscopy NER1006 Plenvu Polyethylene glycol Bowel preparation |
| topic |
Colonoscopy NER1006 Plenvu Polyethylene glycol Bowel preparation |
| description |
Background and study aims Effective bowel cleansing is critical for detecting lesions during colonoscopy, highlighting the importance of bowel preparations. 1L polyethylene glycol (PEG) + ascorbate (Asc) is the only recommended 1L PEG product in Europe and the United States. Its efficacy was demonstrated in large-scale controlled trials and confirmed in smaller-scale real-world studies. However, no large-scale real-world data exist. Patients and methods This observational, retrospective, multicenter study, used outpatient follow-up data from medical records from 10 centers in Spain and two in Portugal. Outpatients aged ≥18 years using 1L PEG + Asc as bowel preparation were included. The main outcome measures were overall adequate colon cleansing (Boston Bowel Preparation Scale [BBPS] score ≥6 with BBPS score ≥2 in each segment) and high-quality cleansing of the right colon (BBPS score=3). Results Data from 13169 eligible patients were included. Overall cleansing success was achieved in 89.3% (95%CI 88.7%-89.8%) and high-quality cleansing in the right colon in 49.3% (95%CI 48.4%-50.2%) of patients. For the overnight split-dose and same-day regimens, overall adequate quality cleansing success rate was 94.7% and 86.7% ( P <0.0001) and high-quality cleansing of the right colon rate was 65.4% and 41.4% ( P <0.0001), respectively. Colonoscopy was completed in 97.3% of patients, with non-completion due to poor preparation in only 0.8%; 2.3% of patients experienced at least one adverse event (AE). Conclusions This large-scale, real-world study demonstrates the effectiveness of 1L PEG + Asc in the total and right colon, with a low percentage of patients with AEs in routine clinical practice. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/60019 http://dx.doi.org/10.1055/a-2125-0025 |
| url |
http://hdl.handle.net/10230/60019 http://dx.doi.org/10.1055/a-2125-0025 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Endosc Int Open. 2023 Aug 16;11(8):E785-93 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Georg Thieme Verlag KG |
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Georg Thieme Verlag KG |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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