The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition

The precise mechanisms underlying the cellular response to static electric cues remain unclear, limiting the design and development of biomaterials that utilize this parameter to enhance specific biological behaviours. To gather information on this matter we have explored the interaction of collagen...

Descripción completa

Detalles Bibliográficos
Autores: Rodriguez-Lejarraga, Paula, Martin-Iglesias, Sara, Moneo-Corcuera, Andrea, Colom, Adai, Redondo-Morata, Lorena, Giannotti, Marina Inés, Petrenko, Viktor, Monleón-Guinot, Irene, Mata, Manuel, Silvan, Unai, Lanceros-Mendez, Senentxu
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219450
Acceso en línea:https://hdl.handle.net/2445/219450
Access Level:acceso embargado
Palabra clave:Revestiments
Matriu extracel·lular
Col·lagen
Coatings
Extracellular matrix
Collagen
id ES_3f4a2ba45db2fefd0dd1f76884dbf68a
oai_identifier_str oai:recercat.cat:2445/219450
network_acronym_str ES
network_name_str España
repository_id_str
spelling The surface charge of electroactive materials governs cell behaviour through its effect on protein depositionRodriguez-Lejarraga, PaulaMartin-Iglesias, SaraMoneo-Corcuera, AndreaColom, AdaiRedondo-Morata, LorenaGiannotti, Marina InésPetrenko, ViktorMonleón-Guinot, IreneMata, ManuelSilvan, UnaiLanceros-Mendez, SenentxuRevestimentsMatriu extracel·lularCol·lagenCoatingsExtracellular matrixCollagenThe precise mechanisms underlying the cellular response to static electric cues remain unclear, limiting the design and development of biomaterials that utilize this parameter to enhance specific biological behaviours. To gather information on this matter we have explored the interaction of collagen type-I, the most abundant mammalian extracellular protein, with polyvinylidene fluoride (PVDF), an electroactive polymer with great potential for tissue engineering applications. Our results reveal significant differences in collagen affinity, conformation, and interaction strength depending on the electric charge of the PVDF surface, which subsequently affects the behaviour of mesenchymal stem cells seeded on them. These findings highlight the importance of surface charge in the establishment of the material-protein interface and ultimately in the biological response to the material.Elsevier B.V.202520242025infoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion9 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/219450Articles publicats en revistes (Ciència dels Materials i Química Física)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.actbio.2024.06.039Acta Biomaterialia, 2024, vol. 184, p. 201-209https://doi.org/10.1016/j.actbio.2024.06.039cc-by-nc-nd (c) Elsevier B.V., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:recercat.cat:2445/2194502026-05-29T05:05:01Z
dc.title.none.fl_str_mv The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
title The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
spellingShingle The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
Rodriguez-Lejarraga, Paula
Revestiments
Matriu extracel·lular
Col·lagen
Coatings
Extracellular matrix
Collagen
title_short The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
title_full The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
title_fullStr The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
title_full_unstemmed The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
title_sort The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
dc.creator.none.fl_str_mv Rodriguez-Lejarraga, Paula
Martin-Iglesias, Sara
Moneo-Corcuera, Andrea
Colom, Adai
Redondo-Morata, Lorena
Giannotti, Marina Inés
Petrenko, Viktor
Monleón-Guinot, Irene
Mata, Manuel
Silvan, Unai
Lanceros-Mendez, Senentxu
author Rodriguez-Lejarraga, Paula
author_facet Rodriguez-Lejarraga, Paula
Martin-Iglesias, Sara
Moneo-Corcuera, Andrea
Colom, Adai
Redondo-Morata, Lorena
Giannotti, Marina Inés
Petrenko, Viktor
Monleón-Guinot, Irene
Mata, Manuel
Silvan, Unai
Lanceros-Mendez, Senentxu
author_role author
author2 Martin-Iglesias, Sara
Moneo-Corcuera, Andrea
Colom, Adai
Redondo-Morata, Lorena
Giannotti, Marina Inés
Petrenko, Viktor
Monleón-Guinot, Irene
Mata, Manuel
Silvan, Unai
Lanceros-Mendez, Senentxu
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Revestiments
Matriu extracel·lular
Col·lagen
Coatings
Extracellular matrix
Collagen
topic Revestiments
Matriu extracel·lular
Col·lagen
Coatings
Extracellular matrix
Collagen
description The precise mechanisms underlying the cellular response to static electric cues remain unclear, limiting the design and development of biomaterials that utilize this parameter to enhance specific biological behaviours. To gather information on this matter we have explored the interaction of collagen type-I, the most abundant mammalian extracellular protein, with polyvinylidene fluoride (PVDF), an electroactive polymer with great potential for tissue engineering applications. Our results reveal significant differences in collagen affinity, conformation, and interaction strength depending on the electric charge of the PVDF surface, which subsequently affects the behaviour of mesenchymal stem cells seeded on them. These findings highlight the importance of surface charge in the establishment of the material-protein interface and ultimately in the biological response to the material.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219450
url https://hdl.handle.net/2445/219450
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.actbio.2024.06.039
Acta Biomaterialia, 2024, vol. 184, p. 201-209
https://doi.org/10.1016/j.actbio.2024.06.039
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Ciència dels Materials i Química Física)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406623059935232
score 15,811543

Similares en LA Referencia