Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models

Heart failure (HF) is a major cause of death and hospitalization worldwide. Despite advances in reducing mortality, prognosis remains poor and prevalence has reached epidemic proportions. The limitations of available preclinical models represent a major hurdle in the development of new therapies. My...

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Detalles Bibliográficos
Autores: Villalba-Orero, Maria, Lopez-Olaneta, Marina, García-Pavía, Pablo, Lara-Pezzi, Enrique
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7986
Acceso en línea:http://hdl.handle.net/20.500.12105/7986
Access Level:acceso abierto
Palabra clave:Animals
Disease Models, Animal
Disease Progression
Heart Failure
Hypertrophy, Left Ventricular
Male
Mice, Inbred C57BL
Myocardial Infarction
Myocardium
Species Specificity
Stroke Volume
Systole
Time Factors
Ventricular Dysfunction, Left
Ventricular Remodeling
Ventricular Function, Left
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oai_identifier_str oai:repisalud.isciii.es:20.500.12105/7986
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spelling Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical ModelsVillalba-Orero, MariaLopez-Olaneta, MarinaGarcía-Pavía, PabloLara-Pezzi, EnriqueAnimalsDisease Models, AnimalDisease ProgressionHeart FailureHypertrophy, Left VentricularMaleMice, Inbred C57BLMyocardial InfarctionMyocardiumSpecies SpecificityStroke VolumeSystoleTime FactorsVentricular Dysfunction, LeftVentricular RemodelingVentricular Function, LeftHeart failure (HF) is a major cause of death and hospitalization worldwide. Despite advances in reducing mortality, prognosis remains poor and prevalence has reached epidemic proportions. The limitations of available preclinical models represent a major hurdle in the development of new therapies. Myocardial infarction (MI) is a main cause of HF in humans, and mouse models of MI are often used to study HF mechanisms and experimental treatments. We investigated whether MI in mice constitutes an appropriate model of HF. Permanent ligation of the left coronary artery induced severe and persistent systolic dysfunction and ventricular dilatation. Mouse follow-up for 10 months showed no significant evidence of lung congestion or other pulmonary defects associated with HF. No difference was observed in the capacity of infarcted mice to exercise compared to control animals. These results indicate that severe cardiac dysfunction in mice is not sufficient to demonstrate the presence of HF.SpringerMinisterio de Economía y Competitividad (España)Comunidad de Madrid (España)Unión Europea. Comisión EuropeaInstituto de Salud Carlos IIIUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Fundación ProCNIC20192019-07-3020172017-12-0120172017-12-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/7986reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme 289600European Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme 608027ES SAF2015-65722-R Not availableES CPII14 00027ES RD12 0042ES SEV-2015-0505 Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/79862026-06-12T12:43:37Z
dc.title.none.fl_str_mv Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
title Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
spellingShingle Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
Villalba-Orero, Maria
Animals
Disease Models, Animal
Disease Progression
Heart Failure
Hypertrophy, Left Ventricular
Male
Mice, Inbred C57BL
Myocardial Infarction
Myocardium
Species Specificity
Stroke Volume
Systole
Time Factors
Ventricular Dysfunction, Left
Ventricular Remodeling
Ventricular Function, Left
title_short Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
title_full Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
title_fullStr Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
title_full_unstemmed Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
title_sort Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
dc.creator.none.fl_str_mv Villalba-Orero, Maria
Lopez-Olaneta, Marina
García-Pavía, Pablo
Lara-Pezzi, Enrique
author Villalba-Orero, Maria
author_facet Villalba-Orero, Maria
Lopez-Olaneta, Marina
García-Pavía, Pablo
Lara-Pezzi, Enrique
author_role author
author2 Lopez-Olaneta, Marina
García-Pavía, Pablo
Lara-Pezzi, Enrique
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Comunidad de Madrid (España)
Unión Europea. Comisión Europea
Instituto de Salud Carlos III
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Fundación ProCNIC
dc.subject.none.fl_str_mv Animals
Disease Models, Animal
Disease Progression
Heart Failure
Hypertrophy, Left Ventricular
Male
Mice, Inbred C57BL
Myocardial Infarction
Myocardium
Species Specificity
Stroke Volume
Systole
Time Factors
Ventricular Dysfunction, Left
Ventricular Remodeling
Ventricular Function, Left
topic Animals
Disease Models, Animal
Disease Progression
Heart Failure
Hypertrophy, Left Ventricular
Male
Mice, Inbred C57BL
Myocardial Infarction
Myocardium
Species Specificity
Stroke Volume
Systole
Time Factors
Ventricular Dysfunction, Left
Ventricular Remodeling
Ventricular Function, Left
description Heart failure (HF) is a major cause of death and hospitalization worldwide. Despite advances in reducing mortality, prognosis remains poor and prevalence has reached epidemic proportions. The limitations of available preclinical models represent a major hurdle in the development of new therapies. Myocardial infarction (MI) is a main cause of HF in humans, and mouse models of MI are often used to study HF mechanisms and experimental treatments. We investigated whether MI in mice constitutes an appropriate model of HF. Permanent ligation of the left coronary artery induced severe and persistent systolic dysfunction and ventricular dilatation. Mouse follow-up for 10 months showed no significant evidence of lung congestion or other pulmonary defects associated with HF. No difference was observed in the capacity of infarcted mice to exercise compared to control animals. These results indicate that severe cardiac dysfunction in mice is not sufficient to demonstrate the presence of HF.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-12-01
2017
2017-12-01
2019
2019-07-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/7986
url http://hdl.handle.net/20.500.12105/7986
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme 289600
European Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme 608027
ES SAF2015-65722-R Not available
ES CPII14 00027
ES RD12 0042
ES SEV-2015-0505 Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-CompartirIgual 4.0 Internacional
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-CompartirIgual 4.0 Internacional
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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