Light-Based Molecular Tools to Precisely Monitor and Operate β-Adrenoceptors
β-Adrenoceptors are important G protein-coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light-based molecular tools have been developed offering precise spatiotemporal control. Fluorescence and bioluminescence techniq...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/404499 |
| Acceso en línea: | http://hdl.handle.net/10261/404499 https://api.elsevier.com/content/abstract/scopus_id/105019335034 |
| Access Level: | acceso abierto |
| Palabra clave: | β‐adrenoceptors Azobenzene Bioluminescence Fluorescence Photopharmacology http://metadata.un.org/sdg/9 http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation Ensure sustainable consumption and production patterns |
| Sumario: | β-Adrenoceptors are important G protein-coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light-based molecular tools have been developed offering precise spatiotemporal control. Fluorescence and bioluminescence techniques allow real-time monitoring of receptor activation and organization, while photopharmacology and optogenetics enable precise external modulation of their activity. A particularly valuable approach involves photoswitchable ligands, which can be switched on and off by specific wavelengths and provide reversible control over receptor activity. In general, the combination of optical biosensing and photopharmacology enhances our ability to analyze GPCR signaling dynamics and function with minimal perturbation. In particular, these approaches open new avenues for targeted research and therapeutic interventions, offering a powerful framework for understanding β-adrenoceptors-related diseases. |
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