Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B

[EN] Biodegradable polymers are an active area of investigation, particularly ones that can be produced from sustainable, biobased monomers, such as copolymers of poly(butylene succinate) (PBS). In this study, we examine the enzymatic degradation of poly(butylene succinate-dilinoleic succinate) (PBS...

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Autores: Wcislek, Aleksandra, McClain, Andrew, Piegat, Agnieszka, Sobolewski, Peter, Puskas, Judit, El Fray, Miroslawa, Sonseca Olalla, Agueda|||0000-0002-2776-4399
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/204670
Acceso en línea:https://riunet.upv.es/handle/10251/204670
Access Level:acceso abierto
Palabra clave:Electrospinning
Enzymatic degradation
Fatty acid
Nanofibers
Poly(butylene succinate) (PBS)
Polyester copolymers
CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA
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spelling Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase BWcislek, AleksandraMcClain, AndrewPiegat, AgnieszkaSobolewski, PeterPuskas, JuditEl Fray, MiroslawaSonseca Olalla, Agueda|||0000-0002-2776-4399ElectrospinningEnzymatic degradationFatty acidNanofibersPoly(butylene succinate) (PBS)Polyester copolymersCIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA[EN] Biodegradable polymers are an active area of investigation, particularly ones that can be produced from sustainable, biobased monomers, such as copolymers of poly(butylene succinate) (PBS). In this study, we examine the enzymatic degradation of poly(butylene succinate-dilinoleic succinate) (PBS-DLS) copolymers obtained by green enzymatic synthesis using lipase B from Candida antarctica (CALB). The copolymers differed in their hard to soft segments ratio, from 70:30 to 50:50 wt %. Enzymatic degradation was carried out on electrospun membranes (scaffolds) and compression-moulded films using lipase from Pseudomomas cepacia. Poly(epsilon-caprolactone) (PCL) was used as a reference aliphatic polyester. The degradation process was monitored gravimetrically via water uptake and mass loss. After 24 days, approx. 40% mass loss was observed for fibrous materials prepared from the PBS-DLS 70:30 copolymer, as compared to approx. 10% mass loss for PBS-DLS 50:50. Infrared spectroscopy (FTIR) and size exclusion chromatography (SEC) analysis were used to examine changes in chemical structure. Differential scanning calorimetry (DSC) and scanning light microscopy (LSM) revealed changes in degree of crystallinity, and changes in surface morphology, consistent with a surface erosion mechanism. We conclude that the obtained copolymers are suitable for tissue engineering applications thanks to tuneable degradation and lack of acidification during breakdown.This work was financially supported by the National Science Centre, Poland, underthe HARMONIA program under agreement No.UMO-2014/14/M/ST00610. ASO acknowledge the Juan de la Cierva ·(FJCI-2015-24405) contract from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO).MDPI AGEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialDepartamento de Ingeniería Mecánica y de MaterialesEscuela Técnica Superior de Ingeniería Industrial Instituto Universitario de Investigación de Tecnología de los Materiales de la UPVNational Science Centre, PoloniaMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20182018-06-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/204670reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 FJCI-2015-24405 FJCI-2015-24405National Science Centre, Polonia https://doi.org/10.13039/501100004281 UMO-2014%2F14%2FM%2FST00610open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2046702026-06-13T07:49:27Z
dc.title.none.fl_str_mv Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B
title Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B
spellingShingle Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B
Wcislek, Aleksandra
Electrospinning
Enzymatic degradation
Fatty acid
Nanofibers
Poly(butylene succinate) (PBS)
Polyester copolymers
CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA
title_short Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B
title_full Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B
title_fullStr Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B
title_full_unstemmed Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B
title_sort Enzymatic Degradation of Poly(butylene succinate) Copolyesters Synthesized with the Use of Candida antarctica Lipase B
dc.creator.none.fl_str_mv Wcislek, Aleksandra
McClain, Andrew
Piegat, Agnieszka
Sobolewski, Peter
Puskas, Judit
El Fray, Miroslawa
Sonseca Olalla, Agueda|||0000-0002-2776-4399
author Wcislek, Aleksandra
author_facet Wcislek, Aleksandra
McClain, Andrew
Piegat, Agnieszka
Sobolewski, Peter
Puskas, Judit
El Fray, Miroslawa
Sonseca Olalla, Agueda|||0000-0002-2776-4399
author_role author
author2 McClain, Andrew
Piegat, Agnieszka
Sobolewski, Peter
Puskas, Judit
El Fray, Miroslawa
Sonseca Olalla, Agueda|||0000-0002-2776-4399
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Departamento de Ingeniería Mecánica y de Materiales
Escuela Técnica Superior de Ingeniería Industrial
 Instituto Universitario de Investigación de Tecnología de los Materiales de la UPV
National Science Centre, Polonia
Ministerio de Economía y Competitividad
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Electrospinning
Enzymatic degradation
Fatty acid
Nanofibers
Poly(butylene succinate) (PBS)
Polyester copolymers
CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA
topic Electrospinning
Enzymatic degradation
Fatty acid
Nanofibers
Poly(butylene succinate) (PBS)
Polyester copolymers
CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA
description [EN] Biodegradable polymers are an active area of investigation, particularly ones that can be produced from sustainable, biobased monomers, such as copolymers of poly(butylene succinate) (PBS). In this study, we examine the enzymatic degradation of poly(butylene succinate-dilinoleic succinate) (PBS-DLS) copolymers obtained by green enzymatic synthesis using lipase B from Candida antarctica (CALB). The copolymers differed in their hard to soft segments ratio, from 70:30 to 50:50 wt %. Enzymatic degradation was carried out on electrospun membranes (scaffolds) and compression-moulded films using lipase from Pseudomomas cepacia. Poly(epsilon-caprolactone) (PCL) was used as a reference aliphatic polyester. The degradation process was monitored gravimetrically via water uptake and mass loss. After 24 days, approx. 40% mass loss was observed for fibrous materials prepared from the PBS-DLS 70:30 copolymer, as compared to approx. 10% mass loss for PBS-DLS 50:50. Infrared spectroscopy (FTIR) and size exclusion chromatography (SEC) analysis were used to examine changes in chemical structure. Differential scanning calorimetry (DSC) and scanning light microscopy (LSM) revealed changes in degree of crystallinity, and changes in surface morphology, consistent with a surface erosion mechanism. We conclude that the obtained copolymers are suitable for tissue engineering applications thanks to tuneable degradation and lack of acidification during breakdown.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-06-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/204670
url https://riunet.upv.es/handle/10251/204670
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 FJCI-2015-24405 FJCI-2015-24405
National Science Centre, Polonia https://doi.org/10.13039/501100004281 UMO-2014%2F14%2FM%2FST00610
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406611680788480
score 15.300724

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