Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats

et al.

Bibliographic Details
Authors: Weber, Ralph, Ramos-Cabrer, Pedro, Justicia, Carles, Wiedermann, Dirk, Hoehn, Mathias
Format: article
Publication Date:2008
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/32469
Online Access:http://hdl.handle.net/10261/32469
Access Level:Open access
Keyword:fMRI
Neurovascular coupling
Functional reorganization
Stroke
Functional recovery
Ischemia
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spelling Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in ratsWeber, RalphRamos-Cabrer, PedroJusticia, CarlesWiedermann, DirkHoehn, MathiasfMRINeurovascular couplingFunctional reorganizationStrokeFunctional recoveryIschemiaet al.Therapeutic success of treatment of cerebral diseases must be assessed in terms of functional outcome. In experimental stroke studies, this has been limited to behavioral studies combined with morphological evaluations and single time point functional magnetic resonance imaging (fMRI) measurements butlacking the access to understanding underlying mechanisms for alterations in brain activation. Using a recently developed blood oxygenation level-dependent fMRI protocol to study longitudinal and intraindividual profiles of functional brain activation in the somatosensory system, we have demonstrated activation reemergence in the original representation field as the basic principle offunctional recovery from experimental stroke. No plastic reorganization has been observed atany time point during 7 weeks after stroke induction. Applying combined recording of fMRI and somatosensory evoked potentials, we observed a tight coupling ofelectrical brain activity and hemodynamic response atall times, indicating persistentpreservation ofneurovascular coupling. Identification of functional brain recovery mechanisms has important implications for the understanding of brain plasticity after cerebral lesions, whereas preservation of neurovascular coupling is important for the clinical translation of fMRI.This work was supported by grants from the Hertie Foundation (Functional Brain Imaging) and through European Union Project LSHB-CT-2006-037526 (StemStroke).Peer reviewedSociety for Neuroscience201120112008info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/32469reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1523/JNEUROSCI.4147-07.2008info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/324692026-05-22T06:33:51Z
dc.title.none.fl_str_mv Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats
title Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats
spellingShingle Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats
Weber, Ralph
fMRI
Neurovascular coupling
Functional reorganization
Stroke
Functional recovery
Ischemia
title_short Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats
title_full Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats
title_fullStr Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats
title_full_unstemmed Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats
title_sort Early prediction of functional recovery after experimental stroke: functional magnetic resonance imaging, electrophysiology, and behavioral testing in rats
dc.creator.none.fl_str_mv Weber, Ralph
Ramos-Cabrer, Pedro
Justicia, Carles
Wiedermann, Dirk
Hoehn, Mathias
author Weber, Ralph
author_facet Weber, Ralph
Ramos-Cabrer, Pedro
Justicia, Carles
Wiedermann, Dirk
Hoehn, Mathias
author_role author
author2 Ramos-Cabrer, Pedro
Justicia, Carles
Wiedermann, Dirk
Hoehn, Mathias
author2_role author
author
author
author
dc.subject.none.fl_str_mv fMRI
Neurovascular coupling
Functional reorganization
Stroke
Functional recovery
Ischemia
topic fMRI
Neurovascular coupling
Functional reorganization
Stroke
Functional recovery
Ischemia
description et al.
publishDate 2008
dc.date.none.fl_str_mv 2008
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/32469
url http://hdl.handle.net/10261/32469
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1523/JNEUROSCI.4147-07.2008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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