Global vs. Local Heating in Magnetic Nanoparticle Hyperthermia
This thesis studies how the efficacy and safety of magnetic nanoparticle hyperthermia (MNH) are affected by variations in local (individual particle level) heat caused by polydispersity in size and anisotropy and the link between local and global (entire system) heat. This is done by using a Metropo...
| Autor: | |
|---|---|
| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/18125 |
| Acceso en línea: | http://hdl.handle.net/10347/18125 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias::Investigación::22 Física::2211 Física del estado sólido::221117 Propiedades magnéticas |
| Sumario: | This thesis studies how the efficacy and safety of magnetic nanoparticle hyperthermia (MNH) are affected by variations in local (individual particle level) heat caused by polydispersity in size and anisotropy and the link between local and global (entire system) heat. This is done by using a Metropolis Monte Carlo computational technique. MNH is a new medical technique whose aim is to destroy cancer cells, which is achieved by introducing magnetic nanoparticles (MNPs) into the tumor and heating them up to 45ºC by applying an alternating magnetic field. The motivation for this thesis arises from two sets of experiments: ones reporting cell death without having a global macroscopic temperature variation and others showing huge temperature gradients in the particle surface rapidly vanishing from it a few nanometers away. These observations go against some commonly presumed ideas about efficacy conditions in MNH and suggest the relevance of investigating local heat. |
|---|