The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium

Alginates are attractive in tissue regeneration due to their similarity to the extracellular matrix, biocompatibility, biodegradability, non-antigenicity, and the ability to undergo ionotropic gelation. Alginate hydrogels are formed by ionic crosslinking mainly using calcium ions with some reports o...

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Detalles Bibliográficos
Autores: Iskandar, L., Rojo, Luis, Di Silvio, L., Deb, S.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/198945
Acceso en línea:http://hdl.handle.net/10261/198945
Access Level:acceso abierto
Palabra clave:Alginate
Bone tissue engineering
Calcium ions
Strontium ions
Zinc ions
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repository_id_str
spelling The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontiumIskandar, L.Rojo, LuisDi Silvio, L.Deb, S.AlginateBone tissue engineeringCalcium ionsStrontium ionsZinc ionsAlginates are attractive in tissue regeneration due to their similarity to the extracellular matrix, biocompatibility, biodegradability, non-antigenicity, and the ability to undergo ionotropic gelation. Alginate hydrogels are formed by ionic crosslinking mainly using calcium ions with some reports on the use of strontium and zinc ions. Strontium and zinc ions in trace amounts are known to accelerate bone healing due to their role in regulating osteoblasts and osteoclasts in addition to their antibacterial properties. This study reports the effect of forming alginate hydrogel films using three different ionic species, Ca, Zn and Sr with different M/G ratios on their physical properties as a method of introducing these ions in alginate composites for bone tissue engineering. The results reveal that mechanical and thermal properties of alginate films along with their water sorption behaviour are affected by the type of ions that crosslink them and the relative amounts of M and G length of the different block structures influence the gel forming ability. Since calcium, zinc and strontium are ions of interest due to their osteogenic properties, the results of this study can be used to tailor the properties of alginates for the development of composite scaffolds for bone tissue regeneration.Peer reviewedSage PublicationsConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/198945reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1177/0885328219861904Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1989452026-05-22T06:33:51Z
dc.title.none.fl_str_mv The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium
title The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium
spellingShingle The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium
Iskandar, L.
Alginate
Bone tissue engineering
Calcium ions
Strontium ions
Zinc ions
title_short The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium
title_full The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium
title_fullStr The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium
title_full_unstemmed The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium
title_sort The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium
dc.creator.none.fl_str_mv Iskandar, L.
Rojo, Luis
Di Silvio, L.
Deb, S.
author Iskandar, L.
author_facet Iskandar, L.
Rojo, Luis
Di Silvio, L.
Deb, S.
author_role author
author2 Rojo, Luis
Di Silvio, L.
Deb, S.
author2_role author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Alginate
Bone tissue engineering
Calcium ions
Strontium ions
Zinc ions
topic Alginate
Bone tissue engineering
Calcium ions
Strontium ions
Zinc ions
description Alginates are attractive in tissue regeneration due to their similarity to the extracellular matrix, biocompatibility, biodegradability, non-antigenicity, and the ability to undergo ionotropic gelation. Alginate hydrogels are formed by ionic crosslinking mainly using calcium ions with some reports on the use of strontium and zinc ions. Strontium and zinc ions in trace amounts are known to accelerate bone healing due to their role in regulating osteoblasts and osteoclasts in addition to their antibacterial properties. This study reports the effect of forming alginate hydrogel films using three different ionic species, Ca, Zn and Sr with different M/G ratios on their physical properties as a method of introducing these ions in alginate composites for bone tissue engineering. The results reveal that mechanical and thermal properties of alginate films along with their water sorption behaviour are affected by the type of ions that crosslink them and the relative amounts of M and G length of the different block structures influence the gel forming ability. Since calcium, zinc and strontium are ions of interest due to their osteogenic properties, the results of this study can be used to tailor the properties of alginates for the development of composite scaffolds for bone tissue regeneration.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/198945
url http://hdl.handle.net/10261/198945
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1177/0885328219861904
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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