Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study

Introduction: Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, whereas a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to verify the association of MRE metrics with histologic fibrosis independent of...

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Autores: Coimbra, Alexandre, Rimola Gibert, Jordi, Cuatrecasas Freixas, Miriam, De Hertogh, Gert, Van Assche, Gert, Vanslembrouck, Ragna, Glerup, Henning, Hedemann Nielsen, Agnete, Hagemann-Madsen, Rikke, Bouhnik, Yoram, Zappa, Magaly, Cazals-Hatem, Dominique, D'Haens, Geert, Stoker, Jaap, Meijer, Sybren, Rogler, Gerhard, Boss, Andreas, Weber, Achim, Zhao, Rui, Keir, Mary E., Scherl, Alexis, De Crespigny, Alex, Lu, Timothy T., Panés Díaz, Julià
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/201343
Acceso en línea:https://hdl.handle.net/2445/201343
Access Level:acceso abierto
Palabra clave:Malaltia de Crohn
Diagnòstic per la imatge
Histologia
Estenosi
Inflamació
Crohn's disease
Diagnostic imaging
Histology
Stenosis
Inflammation
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spelling Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter studyCoimbra, AlexandreRimola Gibert, JordiCuatrecasas Freixas, MiriamDe Hertogh, GertVan Assche, GertVanslembrouck, RagnaGlerup, HenningHedemann Nielsen, AgneteHagemann-Madsen, RikkeBouhnik, YoramZappa, MagalyCazals-Hatem, DominiqueD'Haens, GeertStoker, JaapMeijer, SybrenRogler, GerhardBoss, AndreasWeber, AchimZhao, RuiKeir, Mary E.Scherl, AlexisDe Crespigny, AlexLu, Timothy T.Panés Díaz, JuliàMalaltia de CrohnDiagnòstic per la imatgeHistologiaEstenosiInflamacióCrohn's diseaseDiagnostic imagingHistologyStenosisInflammationIntroduction: Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, whereas a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to verify the association of MRE metrics with histologic fibrosis independent of inflammation. Methods: This prospective European multicenter study performed MRE imaging on 60 patients with CD with bowel strictures before surgical resection. Locations of 61 histological samples were annotated on MRE examinations, followed by central readings using the Chiorean score and measurement of delayed gain of enhancement (DGE), magnetization transfer ratio, T2-weighted MRI sequences (T2R), apparent diffusion coefficient (ADC), and the magnetic resonance index of activity (MaRIA). Correlations of histology and MRE metrics were assessed. Least Absolute Shrinkage and Selection Operator and receiver operator characteristic (ROC) curve analyses were used to select composite MRE scores predictive of histology and to estimate their predictive value. Results: ADC and MaRIA correlated with fibrosis (R = -0.71, P < 0.0001, and 0.59, P < 0.001) and more moderately with inflammation (R = -0.35, P < 0.01, and R = 0.53, P < 0.001). Lower or no correlations of fibrosis or inflammation were found with DGE, magnetization transfer ratio, or T2R. Least Absolute Shrinkage and Selection Operator and ROC identified a composite score of MaRIA, ADC, and DGE as a very good predictor of histologic fibrosis (ROC area under the curve = 0.910). MaRIA alone was the best predictor of histologic inflammation with excellent performance in identifying active histologic inflammation (ROC area under the curve = 0.966). Discussion: MRE-based scores for histologic fibrosis and inflammation may assist in the characterization of CD stenosis and enable development of fibrosis-targeted therapies and clinical treatment of stenotic patients.Wolters Kluwer Health2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/2445/201343Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.14309/ctg.0000000000000505Clinical and Translational Gastroenterology, 2022, vol. 13, num. 7, p. e00505https://doi.org/10.14309/ctg.0000000000000505cc-by-nc-nd (c) Coimbra, Alexandre et al., 2022https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2013432026-05-29T05:05:01Z
dc.title.none.fl_str_mv Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study
title Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study
spellingShingle Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study
Coimbra, Alexandre
Malaltia de Crohn
Diagnòstic per la imatge
Histologia
Estenosi
Inflamació
Crohn's disease
Diagnostic imaging
Histology
Stenosis
Inflammation
title_short Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study
title_full Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study
title_fullStr Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study
title_full_unstemmed Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study
title_sort Magnetic resonance enterography and histology in patients with fibrostenotic Crohn's disease: A multicenter study
dc.creator.none.fl_str_mv Coimbra, Alexandre
Rimola Gibert, Jordi
Cuatrecasas Freixas, Miriam
De Hertogh, Gert
Van Assche, Gert
Vanslembrouck, Ragna
Glerup, Henning
Hedemann Nielsen, Agnete
Hagemann-Madsen, Rikke
Bouhnik, Yoram
Zappa, Magaly
Cazals-Hatem, Dominique
D'Haens, Geert
Stoker, Jaap
Meijer, Sybren
Rogler, Gerhard
Boss, Andreas
Weber, Achim
Zhao, Rui
Keir, Mary E.
Scherl, Alexis
De Crespigny, Alex
Lu, Timothy T.
Panés Díaz, Julià
author Coimbra, Alexandre
author_facet Coimbra, Alexandre
Rimola Gibert, Jordi
Cuatrecasas Freixas, Miriam
De Hertogh, Gert
Van Assche, Gert
Vanslembrouck, Ragna
Glerup, Henning
Hedemann Nielsen, Agnete
Hagemann-Madsen, Rikke
Bouhnik, Yoram
Zappa, Magaly
Cazals-Hatem, Dominique
D'Haens, Geert
Stoker, Jaap
Meijer, Sybren
Rogler, Gerhard
Boss, Andreas
Weber, Achim
Zhao, Rui
Keir, Mary E.
Scherl, Alexis
De Crespigny, Alex
Lu, Timothy T.
Panés Díaz, Julià
author_role author
author2 Rimola Gibert, Jordi
Cuatrecasas Freixas, Miriam
De Hertogh, Gert
Van Assche, Gert
Vanslembrouck, Ragna
Glerup, Henning
Hedemann Nielsen, Agnete
Hagemann-Madsen, Rikke
Bouhnik, Yoram
Zappa, Magaly
Cazals-Hatem, Dominique
D'Haens, Geert
Stoker, Jaap
Meijer, Sybren
Rogler, Gerhard
Boss, Andreas
Weber, Achim
Zhao, Rui
Keir, Mary E.
Scherl, Alexis
De Crespigny, Alex
Lu, Timothy T.
Panés Díaz, Julià
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Crohn
Diagnòstic per la imatge
Histologia
Estenosi
Inflamació
Crohn's disease
Diagnostic imaging
Histology
Stenosis
Inflammation
topic Malaltia de Crohn
Diagnòstic per la imatge
Histologia
Estenosi
Inflamació
Crohn's disease
Diagnostic imaging
Histology
Stenosis
Inflammation
description Introduction: Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, whereas a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to verify the association of MRE metrics with histologic fibrosis independent of inflammation. Methods: This prospective European multicenter study performed MRE imaging on 60 patients with CD with bowel strictures before surgical resection. Locations of 61 histological samples were annotated on MRE examinations, followed by central readings using the Chiorean score and measurement of delayed gain of enhancement (DGE), magnetization transfer ratio, T2-weighted MRI sequences (T2R), apparent diffusion coefficient (ADC), and the magnetic resonance index of activity (MaRIA). Correlations of histology and MRE metrics were assessed. Least Absolute Shrinkage and Selection Operator and receiver operator characteristic (ROC) curve analyses were used to select composite MRE scores predictive of histology and to estimate their predictive value. Results: ADC and MaRIA correlated with fibrosis (R = -0.71, P < 0.0001, and 0.59, P < 0.001) and more moderately with inflammation (R = -0.35, P < 0.01, and R = 0.53, P < 0.001). Lower or no correlations of fibrosis or inflammation were found with DGE, magnetization transfer ratio, or T2R. Least Absolute Shrinkage and Selection Operator and ROC identified a composite score of MaRIA, ADC, and DGE as a very good predictor of histologic fibrosis (ROC area under the curve = 0.910). MaRIA alone was the best predictor of histologic inflammation with excellent performance in identifying active histologic inflammation (ROC area under the curve = 0.966). Discussion: MRE-based scores for histologic fibrosis and inflammation may assist in the characterization of CD stenosis and enable development of fibrosis-targeted therapies and clinical treatment of stenotic patients.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/201343
url https://hdl.handle.net/2445/201343
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.14309/ctg.0000000000000505
Clinical and Translational Gastroenterology, 2022, vol. 13, num. 7, p. e00505
https://doi.org/10.14309/ctg.0000000000000505
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Coimbra, Alexandre et al., 2022
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Coimbra, Alexandre et al., 2022
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health
publisher.none.fl_str_mv Wolters Kluwer Health
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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