A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing

28 p.-4 fig.-4 tab.

Detalles Bibliográficos
Autores: Rodríguez-Fernández, José Luis, Criado-García, Olga
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/285512
Acceso en línea:http://hdl.handle.net/10261/285512
Access Level:acceso abierto
Palabra clave:Chemoattractant
Chemoattractant receptor
Chemotaxis
Chemoattraction
Directional sensing
Motility
Migration
Actin
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spelling A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensingRodríguez-Fernández, José LuisCriado-García, OlgaChemoattractantChemoattractant receptorChemotaxisChemoattractionDirectional sensingMotilityMigrationActin28 p.-4 fig.-4 tab.Chemoattraction, defined as the migration of a cell toward a source of a chemical gradient, is controlled by chemoattractant receptors. Chemoattraction involves two basic activities, namely, directional sensing, a molecular mechanism that detects the direction of a source of chemoattractant, and actin-based motility, which allows the migration of a cell towards it. Current models assume first, that chemoattractant receptors govern both directional sensing and motility (most commonly inducing an increase in the migratory speed of the cells, i.e. chemokinesis), and, second, that the signaling pathways controlling both activities are intertwined. We performed a meta-analysis to reassess these two points. From this study emerge two main findings. First, although many chemoattractant receptors govern directional sensing, there are also receptors that do not regulate cell motility, suggesting that is the ability to control directional sensing, not motility, that best defines a chemoattractant receptor. Second, multiple experimental data suggest that receptor-controlled directional sensing and motility can be controlled independently. We hypothesize that this independence may be based on the existence of separated signalling modules that selectively govern directional sensing and motility in chemotactic cells. Together, the information gathered can be useful to update current models representing the signalling from chemoattractant receptors. The new models may facilitate the development of strategies for a more effective pharmacological modulation of chemoattractant receptor-controlled chemoattraction in health and disease. “We shall not cease from exploration And the end of all our exploring Will be to arrive where we started And know the place for the first time” from “Little Gidding” by T.S. ElliotThis work was supported by grants SAF-2014-53151-R (Ministerio de Economía y Competitividad), SAF2017-83306-R (Ministerio de Ciencia, Innovación y Universidades), RIER (RETICS Program/Instituto de Salud Carlos III) (RD08/0075, RD16/0012/0007) and PID2020-114147RB-100 (Ministerio de Ciencia e Innovación).Peer reviewedFrontiers MediaMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Instituto de Salud Carlos IIIMinisterio de Ciencia e Innovación (España)Rodríguez-Fernández, José Luis [0000-0001-8874-1425]Criado-García, Olga [0000-0003-1200-6365]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/285512reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83306-Rhttps://doi.org/10.3389/fimmu.2022.1001086Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2855122026-05-22T06:33:51Z
dc.title.none.fl_str_mv A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing
title A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing
spellingShingle A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing
Rodríguez-Fernández, José Luis
Chemoattractant
Chemoattractant receptor
Chemotaxis
Chemoattraction
Directional sensing
Motility
Migration
Actin
title_short A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing
title_full A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing
title_fullStr A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing
title_full_unstemmed A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing
title_sort A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing
dc.creator.none.fl_str_mv Rodríguez-Fernández, José Luis
Criado-García, Olga
author Rodríguez-Fernández, José Luis
author_facet Rodríguez-Fernández, José Luis
Criado-García, Olga
author_role author
author2 Criado-García, Olga
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Instituto de Salud Carlos III
Ministerio de Ciencia e Innovación (España)
Rodríguez-Fernández, José Luis [0000-0001-8874-1425]
Criado-García, Olga [0000-0003-1200-6365]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Chemoattractant
Chemoattractant receptor
Chemotaxis
Chemoattraction
Directional sensing
Motility
Migration
Actin
topic Chemoattractant
Chemoattractant receptor
Chemotaxis
Chemoattraction
Directional sensing
Motility
Migration
Actin
description 28 p.-4 fig.-4 tab.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/285512
url http://hdl.handle.net/10261/285512
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83306-R
https://doi.org/10.3389/fimmu.2022.1001086
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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