A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management

Malaltia renal crònica; Obesitat; Trasplantament de ronyó

Bibliographic Details
Authors: Vergara Arana, Ander, Bermejo Garcia, Sheila, Azancot Rivero, M Antonieta, Sellarés Roig, Joana, Soler Romeo, Maria Jose, García-Carro, Clara
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Departament de Salut de la Generalitat de Catalunya (DS)
Repository:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/6658
Online Access:https://hdl.handle.net/11351/6658
Access Level:Open access
Keyword:Obesitat - Tractament
Ronyons - Malalties - Complicacions
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
Other subheadings::Other subheadings::Other subheadings::/drug therapy
DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
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spelling A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical ManagementVergara Arana, AnderBermejo Garcia, SheilaAzancot Rivero, M AntonietaSellarés Roig, JoanaSoler Romeo, Maria JoseGarcía-Carro, ClaraObesitat - TractamentRonyons - Malalties - ComplicacionsDISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::ObesityOther subheadings::Other subheadings::Other subheadings::/drug therapyDISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney DiseasesOther subheadings::Other subheadings::Other subheadings::/complicationsENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidadOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renalesOtros calificadores::Otros calificadores::Otros calificadores::/complicacionesMalaltia renal crònica; Obesitat; Trasplantament de ronyóEnfermedad renal crónica; Obesidad; Trasplante de riñónChronic kidney disease; Obesity; Kidney transplantationObesity is one of the epidemics of our era. Its prevalence is higher than 30% in the U.S. and it is estimated to increase by 50% in 2030. Obesity is associated with a higher risk of all-cause mortality and it is known to be a cause of chronic kidney disease (CKD). Typically, obesity-related glomerulopathy (ORG) is ascribed to renal hemodynamic changes that lead to hyperfiltration, albuminuria and, finally, impairment in glomerular filtration rate due to glomerulosclerosis. Though not only hemodynamics are responsible for ORG: adipokines could cause local effects on mesangial and tubular cells and podocytes promoting maladaptive responses to hyperfiltration. Furthermore, hypertension and type 2 diabetes mellitus, two conditions generally associated with obesity, are both amplifiers of obesity injury in the renal parenchyma, as well as complications of overweight. As in the native kidney, obesity is also related to worse outcomes in kidney transplantation. Despite its impact in CKD and cardiovascular morbility and mortality, therapeutic strategies to fight against obesity-related CKD were limited for decades to renin-angiotensin blockade and bariatric surgery for patients who accomplished very restrictive criteria. Last years, different drugs have been approved or are under study for the treatment of obesity. Glucagon-like peptide-1 receptor agonists are promising in obesity-related CKD since they have shown benefits in terms of losing weight in obese patients, as well as preventing the onset of macroalbuminuria and slowing the decline of eGFR in type 2 diabetes. These new families of glucose-lowering drugs are a new frontier to be crossed by nephrologists to stop obesity-related CKD progression.Frontiers MediaInstitut Català de la Salut[García-Carro C] Nephrology Department, San Carlos Clinical University Hospital, Madrid, Spain. [Vergara A, Bermejo S, Azancot MA, Sellarés J, Soler MJ] Servei de Nefrologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Nefrologia, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/6658Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésFrontiers in Medicine;8https://doi.org/10.3389/fmed.2021.655871Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/66582026-06-12T09:38:37Z
dc.title.none.fl_str_mv A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
title A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
spellingShingle A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
Vergara Arana, Ander
Obesitat - Tractament
Ronyons - Malalties - Complicacions
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
Other subheadings::Other subheadings::Other subheadings::/drug therapy
DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
title_short A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
title_full A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
title_fullStr A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
title_full_unstemmed A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
title_sort A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
dc.creator.none.fl_str_mv Vergara Arana, Ander
Bermejo Garcia, Sheila
Azancot Rivero, M Antonieta
Sellarés Roig, Joana
Soler Romeo, Maria Jose
García-Carro, Clara
author Vergara Arana, Ander
author_facet Vergara Arana, Ander
Bermejo Garcia, Sheila
Azancot Rivero, M Antonieta
Sellarés Roig, Joana
Soler Romeo, Maria Jose
García-Carro, Clara
author_role author
author2 Bermejo Garcia, Sheila
Azancot Rivero, M Antonieta
Sellarés Roig, Joana
Soler Romeo, Maria Jose
García-Carro, Clara
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[García-Carro C] Nephrology Department, San Carlos Clinical University Hospital, Madrid, Spain. [Vergara A, Bermejo S, Azancot MA, Sellarés J, Soler MJ] Servei de Nefrologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Nefrologia, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Obesitat - Tractament
Ronyons - Malalties - Complicacions
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
Other subheadings::Other subheadings::Other subheadings::/drug therapy
DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
topic Obesitat - Tractament
Ronyons - Malalties - Complicacions
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
Other subheadings::Other subheadings::Other subheadings::/drug therapy
DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
description Malaltia renal crònica; Obesitat; Trasplantament de ronyó
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/6658
url https://hdl.handle.net/11351/6658
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Medicine;8
https://doi.org/10.3389/fmed.2021.655871
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406587865530368
score 15,811543

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