Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats

It has been reported that 17β-estradiol (E2) can exert beneficial effects against the development of obesity, providing women with a healthier metabolic profile and conferring cardiovascular protection. However, a growing body of evidence questions this role in the context of obesity and diabetes. W...

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Detalhes bibliográficos
Autores: Martínez-Cignoni, Melanie Raquel, González-Vicens, Agustí, Morán-Costoya, Andrea, Proenza, Ana Maria, Gianotti, Magdalena, Valle, Adamo, Lladó, Isabel
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositório:Docusalut
Idioma:inglês
OAI Identifier:oai:docusalut.com:20.500.13003/18491
Acesso em linha:https://hdl.handle.net/20.500.13003/18491
Access Level:Acceso aberto
Palavra-chave:Cardiovascular Diseases
Estradiol
Diabetes Mellitus
Diabetes Complications
Female
Rats
Rats, Zucker
Estrogens
Animals
Adipose Tissue
Obesity
Tejido Adiposo
Ratas Zucker
Animales
Ratas
Obesidad
Femenino
Enfermedades Cardiovasculares
Estrógenos
Complicaciones de la Diabetes
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spelling Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female RatsMartínez-Cignoni, Melanie RaquelGonzález-Vicens, AgustíMorán-Costoya, AndreaProenza, Ana MariaGianotti, MagdalenaValle, AdamoLladó, IsabelCardiovascular DiseasesEstradiolDiabetes MellitusDiabetes ComplicationsFemaleRatsRats, ZuckerEstrogensAnimalsAdipose TissueObesityTejido AdiposoRatas ZuckerAnimalesRatasDiabetes MellitusObesidadEstradiolFemeninoEnfermedades CardiovascularesEstrógenosComplicaciones de la DiabetesIt has been reported that 17β-estradiol (E2) can exert beneficial effects against the development of obesity, providing women with a healthier metabolic profile and conferring cardiovascular protection. However, a growing body of evidence questions this role in the context of obesity and diabetes. We focus on the adipose tissue-heart axis to address the question of whether E2 can have metabolically detrimental effects in an obese-diabetic rat model. Female Zucker Diabetic Fatty rats were used: LEAN, fa/+; SHAM, sham-operated fa/fa; OVA, ovariectomized fa/fa, and OVA+E2, ovariectomized and E2 treated fa/fa. The secretory expression profile, tissue expansion parameters and composition of visceral adipose tissue, as well as systemic and cardiac parameters related to insulin resistance, fibrosis, and inflammation were analyzed. Ovariectomy induced an attenuation of both diabetic condition and metabolic dysfunction of adipose tissue and cardiac muscle in fa/fa rats, suggesting that E2, in the context of diabetes and obesity, loses its cardioprotective role and could even contribute to greater metabolic alterations. Adipose tissue from OVA rats showed a healthier hyperplastic expansion pattern, which could help maintain tissue function, increase adiponectin expression, and decrease pro-inflammatory adipokines. These findings should be taken into account when considering hormone replacement therapy for obese-diabetic women.MDPI20212021-12-1720212021-12-17research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/18491reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/184912026-06-22T12:44:07Z
dc.title.none.fl_str_mv Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
title Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
spellingShingle Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
Martínez-Cignoni, Melanie Raquel
Cardiovascular Diseases
Estradiol
Diabetes Mellitus
Diabetes Complications
Female
Rats
Rats, Zucker
Estrogens
Animals
Adipose Tissue
Obesity
Tejido Adiposo
Ratas Zucker
Animales
Ratas
Diabetes Mellitus
Obesidad
Estradiol
Femenino
Enfermedades Cardiovasculares
Estrógenos
Complicaciones de la Diabetes
title_short Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
title_full Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
title_fullStr Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
title_full_unstemmed Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
title_sort Estrogen Impairs Adipose Tissue Expansion and Cardiometabolic Profile in Obese-Diabetic Female Rats
dc.creator.none.fl_str_mv Martínez-Cignoni, Melanie Raquel
González-Vicens, Agustí
Morán-Costoya, Andrea
Proenza, Ana Maria
Gianotti, Magdalena
Valle, Adamo
Lladó, Isabel
author Martínez-Cignoni, Melanie Raquel
author_facet Martínez-Cignoni, Melanie Raquel
González-Vicens, Agustí
Morán-Costoya, Andrea
Proenza, Ana Maria
Gianotti, Magdalena
Valle, Adamo
Lladó, Isabel
author_role author
author2 González-Vicens, Agustí
Morán-Costoya, Andrea
Proenza, Ana Maria
Gianotti, Magdalena
Valle, Adamo
Lladó, Isabel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Cardiovascular Diseases
Estradiol
Diabetes Mellitus
Diabetes Complications
Female
Rats
Rats, Zucker
Estrogens
Animals
Adipose Tissue
Obesity
Tejido Adiposo
Ratas Zucker
Animales
Ratas
Diabetes Mellitus
Obesidad
Estradiol
Femenino
Enfermedades Cardiovasculares
Estrógenos
Complicaciones de la Diabetes
topic Cardiovascular Diseases
Estradiol
Diabetes Mellitus
Diabetes Complications
Female
Rats
Rats, Zucker
Estrogens
Animals
Adipose Tissue
Obesity
Tejido Adiposo
Ratas Zucker
Animales
Ratas
Diabetes Mellitus
Obesidad
Estradiol
Femenino
Enfermedades Cardiovasculares
Estrógenos
Complicaciones de la Diabetes
description It has been reported that 17β-estradiol (E2) can exert beneficial effects against the development of obesity, providing women with a healthier metabolic profile and conferring cardiovascular protection. However, a growing body of evidence questions this role in the context of obesity and diabetes. We focus on the adipose tissue-heart axis to address the question of whether E2 can have metabolically detrimental effects in an obese-diabetic rat model. Female Zucker Diabetic Fatty rats were used: LEAN, fa/+; SHAM, sham-operated fa/fa; OVA, ovariectomized fa/fa, and OVA+E2, ovariectomized and E2 treated fa/fa. The secretory expression profile, tissue expansion parameters and composition of visceral adipose tissue, as well as systemic and cardiac parameters related to insulin resistance, fibrosis, and inflammation were analyzed. Ovariectomy induced an attenuation of both diabetic condition and metabolic dysfunction of adipose tissue and cardiac muscle in fa/fa rats, suggesting that E2, in the context of diabetes and obesity, loses its cardioprotective role and could even contribute to greater metabolic alterations. Adipose tissue from OVA rats showed a healthier hyperplastic expansion pattern, which could help maintain tissue function, increase adiponectin expression, and decrease pro-inflammatory adipokines. These findings should be taken into account when considering hormone replacement therapy for obese-diabetic women.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-12-17
2021
2021-12-17
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/18491
url https://hdl.handle.net/20.500.13003/18491
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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