R-Ras GTPases signaling role in myelin neurodegenerative diseases

Myelination is required for fast and efficient synaptic transmission in vertebrates. In the central nervous system, oligodendrocytes are responsible for creating myelin sheaths that isolate and protect axons, even throughout adulthood. However, when myelin is lost, the failure of remyelination mecha...

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Detalhes bibliográficos
Autores: Alcover Sánchez, Berta, Garcia-Martin, Gonzalo, Wandosell, Francisco
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/708792
Acesso em linha:http://hdl.handle.net/10486/708792
https://dx.doi.org/10.3390/ijms21165911
Access Level:acceso abierto
Palavra-chave:Ras Protein
Demyelinating Diseases
Myelin Sheath
Phosphatidylinositol 3 Kinase
Biología y Biomedicina / Biología
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spelling R-Ras GTPases signaling role in myelin neurodegenerative diseasesAlcover Sánchez, BertaGarcia-Martin, GonzaloWandosell, FranciscoRas ProteinDemyelinating DiseasesMyelin SheathPhosphatidylinositol 3 KinaseBiología y Biomedicina / BiologíaMyelination is required for fast and efficient synaptic transmission in vertebrates. In the central nervous system, oligodendrocytes are responsible for creating myelin sheaths that isolate and protect axons, even throughout adulthood. However, when myelin is lost, the failure of remyelination mechanisms can cause neurodegenerative myelin-associated pathologies. From oligodendrocyte progenitor cells to mature myelinating oligodendrocytes, myelination is a highly complex process that involves many elements of cellular signaling, yet many of the mechanisms that coordinate it, remain unknown. In this review, we will focus on the three major pathways involved in myelination (PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/β-catenin) and recent advances describing the crosstalk elements which help to regulate them. In addition, we will review the tight relation between Ras GTPases and myelination processes and discuss its potential as novel elements of crosstalk between the pathways. A better understanding of the crosstalk elements orchestrating myelination mechanisms is essential to identify new potential targets to mitigate neurodegenerationRTI2018-096303B-C33MDPIDepartamento de Biología MolecularFacultad de Ciencias20202020-08-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/708792https://dx.doi.org/10.3390/ijms21165911reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7087922026-06-23T12:46:27Z
dc.title.none.fl_str_mv R-Ras GTPases signaling role in myelin neurodegenerative diseases
title R-Ras GTPases signaling role in myelin neurodegenerative diseases
spellingShingle R-Ras GTPases signaling role in myelin neurodegenerative diseases
Alcover Sánchez, Berta
Ras Protein
Demyelinating Diseases
Myelin Sheath
Phosphatidylinositol 3 Kinase
Biología y Biomedicina / Biología
title_short R-Ras GTPases signaling role in myelin neurodegenerative diseases
title_full R-Ras GTPases signaling role in myelin neurodegenerative diseases
title_fullStr R-Ras GTPases signaling role in myelin neurodegenerative diseases
title_full_unstemmed R-Ras GTPases signaling role in myelin neurodegenerative diseases
title_sort R-Ras GTPases signaling role in myelin neurodegenerative diseases
dc.creator.none.fl_str_mv Alcover Sánchez, Berta
Garcia-Martin, Gonzalo
Wandosell, Francisco
author Alcover Sánchez, Berta
author_facet Alcover Sánchez, Berta
Garcia-Martin, Gonzalo
Wandosell, Francisco
author_role author
author2 Garcia-Martin, Gonzalo
Wandosell, Francisco
author2_role author
author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Facultad de Ciencias
dc.subject.none.fl_str_mv Ras Protein
Demyelinating Diseases
Myelin Sheath
Phosphatidylinositol 3 Kinase
Biología y Biomedicina / Biología
topic Ras Protein
Demyelinating Diseases
Myelin Sheath
Phosphatidylinositol 3 Kinase
Biología y Biomedicina / Biología
description Myelination is required for fast and efficient synaptic transmission in vertebrates. In the central nervous system, oligodendrocytes are responsible for creating myelin sheaths that isolate and protect axons, even throughout adulthood. However, when myelin is lost, the failure of remyelination mechanisms can cause neurodegenerative myelin-associated pathologies. From oligodendrocyte progenitor cells to mature myelinating oligodendrocytes, myelination is a highly complex process that involves many elements of cellular signaling, yet many of the mechanisms that coordinate it, remain unknown. In this review, we will focus on the three major pathways involved in myelination (PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/β-catenin) and recent advances describing the crosstalk elements which help to regulate them. In addition, we will review the tight relation between Ras GTPases and myelination processes and discuss its potential as novel elements of crosstalk between the pathways. A better understanding of the crosstalk elements orchestrating myelination mechanisms is essential to identify new potential targets to mitigate neurodegeneration
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-08-02
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/708792
https://dx.doi.org/10.3390/ijms21165911
url http://hdl.handle.net/10486/708792
https://dx.doi.org/10.3390/ijms21165911
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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