Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia

Spontaneous swallowing contributes to airway protection and depends on the activation of brainstem reflex circuits in the central pattern generator (CPG). We studied the effect of age and gender on spontaneous swallowing frequency (SSF) in healthy volunteers and assessed basal SSF and TRPV1 stimulat...

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Autores: Nascimento, Weslania Viviane|||0000-0003-1267-3475, Tomsen, Noemí|||0000-0001-7149-7948, Acedo, Saray, Campos Alcantara, Cristina, Cabib, Christopher|||0000-0002-1876-6923, Alvarez-Larruy, Marta, Clavé i Civit, Pere|||0000-0002-0696-8560
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:238531
Acceso en línea:https://ddd.uab.cat/record/238531
https://dx.doi.org/urn:doi:10.3390/diagnostics11030461
Access Level:acceso abierto
Palabra clave:Disorders
Spontaneous swallowing frequency
Capsaicin
TRPV Cation Channels
Stroke
Aging
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spelling Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal DysphagiaA Proof-of-Concept StudyNascimento, Weslania Viviane|||0000-0003-1267-3475Tomsen, Noemí|||0000-0001-7149-7948Acedo, SarayCampos Alcantara, CristinaCabib, Christopher|||0000-0002-1876-6923Alvarez-Larruy, MartaClavé i Civit, Pere|||0000-0002-0696-8560DisordersSpontaneous swallowing frequencyCapsaicinTRPV Cation ChannelsStrokeAgingSpontaneous swallowing contributes to airway protection and depends on the activation of brainstem reflex circuits in the central pattern generator (CPG). We studied the effect of age and gender on spontaneous swallowing frequency (SSF) in healthy volunteers and assessed basal SSF and TRPV1 stimulation effect on SSF in patients with post-stroke oropharyngeal dysphagia (OD). The effect of age and gender on SSF was examined on 141 healthy adult volunteers (HV) divided into three groups: GI-18-39 yr, GII-40-59 yr, and GIII->60 yr. OD was assessed by the Volume-Viscosity Swallowing Test (VVST). The effect of sensory stimulation with capsaicin 10 −5 M (TRPV1 agonist) was evaluated in 17 patients with post-stroke OD, using the SSF. SSF was recorded in all participants during 10 min using surface electromyography (sEMG) of the suprahyoid muscles and an omnidirectional accelerometer placed over the cricothyroid cartilage. SSF was significantly reduced in GII (0.73 ± 0.50 swallows/min; p = 0.0385) and GIII (0.50 ± 0.31 swallows/min; p < 0.0001) compared to GI (1.03 ± 0.62 swallows/min), and there was a moderate significant correlation between age and SFF (r = −0.3810; p < 0.0001). No effect of gender on SSF was observed. Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 ± 0.32 swallows/min vs post-capsaicin: 0.81 ± 0.51 swallow/min; p = 0.0003). OD in patients with post-stroke OD and acute stimulation with TRPV1 agonists caused a significant increase in SSF, further suggesting the potential role of pharmacological stimulation of sensory pathways as a therapeutic strategy for CPG activation in patients with OD. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/238531https://dx.doi.org/urn:doi:10.3390/diagnostics11030461reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 EHD16PI02Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00241Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI20/00117open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2385312026-06-06T12:50:31Z
dc.title.none.fl_str_mv Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia
A Proof-of-Concept Study
title Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia
spellingShingle Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia
Nascimento, Weslania Viviane|||0000-0003-1267-3475
Disorders
Spontaneous swallowing frequency
Capsaicin
TRPV Cation Channels
Stroke
Aging
title_short Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia
title_full Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia
title_fullStr Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia
title_full_unstemmed Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia
title_sort Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia
dc.creator.none.fl_str_mv Nascimento, Weslania Viviane|||0000-0003-1267-3475
Tomsen, Noemí|||0000-0001-7149-7948
Acedo, Saray
Campos Alcantara, Cristina
Cabib, Christopher|||0000-0002-1876-6923
Alvarez-Larruy, Marta
Clavé i Civit, Pere|||0000-0002-0696-8560
author Nascimento, Weslania Viviane|||0000-0003-1267-3475
author_facet Nascimento, Weslania Viviane|||0000-0003-1267-3475
Tomsen, Noemí|||0000-0001-7149-7948
Acedo, Saray
Campos Alcantara, Cristina
Cabib, Christopher|||0000-0002-1876-6923
Alvarez-Larruy, Marta
Clavé i Civit, Pere|||0000-0002-0696-8560
author_role author
author2 Tomsen, Noemí|||0000-0001-7149-7948
Acedo, Saray
Campos Alcantara, Cristina
Cabib, Christopher|||0000-0002-1876-6923
Alvarez-Larruy, Marta
Clavé i Civit, Pere|||0000-0002-0696-8560
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Disorders
Spontaneous swallowing frequency
Capsaicin
TRPV Cation Channels
Stroke
Aging
topic Disorders
Spontaneous swallowing frequency
Capsaicin
TRPV Cation Channels
Stroke
Aging
description Spontaneous swallowing contributes to airway protection and depends on the activation of brainstem reflex circuits in the central pattern generator (CPG). We studied the effect of age and gender on spontaneous swallowing frequency (SSF) in healthy volunteers and assessed basal SSF and TRPV1 stimulation effect on SSF in patients with post-stroke oropharyngeal dysphagia (OD). The effect of age and gender on SSF was examined on 141 healthy adult volunteers (HV) divided into three groups: GI-18-39 yr, GII-40-59 yr, and GIII->60 yr. OD was assessed by the Volume-Viscosity Swallowing Test (VVST). The effect of sensory stimulation with capsaicin 10 −5 M (TRPV1 agonist) was evaluated in 17 patients with post-stroke OD, using the SSF. SSF was recorded in all participants during 10 min using surface electromyography (sEMG) of the suprahyoid muscles and an omnidirectional accelerometer placed over the cricothyroid cartilage. SSF was significantly reduced in GII (0.73 ± 0.50 swallows/min; p = 0.0385) and GIII (0.50 ± 0.31 swallows/min; p < 0.0001) compared to GI (1.03 ± 0.62 swallows/min), and there was a moderate significant correlation between age and SFF (r = −0.3810; p < 0.0001). No effect of gender on SSF was observed. Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 ± 0.32 swallows/min vs post-capsaicin: 0.81 ± 0.51 swallow/min; p = 0.0003). OD in patients with post-stroke OD and acute stimulation with TRPV1 agonists caused a significant increase in SSF, further suggesting the potential role of pharmacological stimulation of sensory pathways as a therapeutic strategy for CPG activation in patients with OD.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/238531
https://dx.doi.org/urn:doi:10.3390/diagnostics11030461
url https://ddd.uab.cat/record/238531
https://dx.doi.org/urn:doi:10.3390/diagnostics11030461
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 EHD16PI02
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00241
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI20/00117
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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