Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry

Herein, a facile water-assisted templating technique, the so-called breath figures method, in combination with phase separation process, was employed to prepare multifunctional micropatterned films. Tetrahydrofuran solutions of incompatible ternary blends consisting of high-molecular-weight polystyr...

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Autores: Sanz de León, Alberto, Campo, Ángel Adolfo del, Fernández-García, Marta, Rodríguez-Hernández, Juan, Muñoz-Bonilla, Alexandra
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/343614
Acceso en línea:http://hdl.handle.net/10261/343614
Access Level:acceso abierto
Palabra clave:breath figures
Polymer blends
porous interfaces
click chemistry
phase separation
polymer surfaces
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spelling Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistrySanz de León, AlbertoCampo, Ángel Adolfo delFernández-García, MartaRodríguez-Hernández, JuanMuñoz-Bonilla, Alexandrabreath figuresPolymer blendsporous interfacesclick chemistryphase separationpolymer surfacesHerein, a facile water-assisted templating technique, the so-called breath figures method, in combination with phase separation process, was employed to prepare multifunctional micropatterned films. Tetrahydrofuran solutions of incompatible ternary blends consisting of high-molecular-weight polystyrene, an amphiphilic block copolymer, polystyrene-b-poly[poly(ethylene glycol) methyl ether methacrylate] (PS40-b-P(PEGMA300)48), and a fluorinated homopolymer, poly(2,3,4,5,6-pentafluorostyrene) (P5FS21) were casted under humid atmosphere varying the proportion of the components. Two simultaneously occurring processes, i.e., the breath figures mechanism and the phase separation process, lead to unprecedented morphologies that could be tuned by simply varying the relative humidity or the composition of the blend. Confocal micro-Raman spectroscopy served to provide information about the location and distribution of the different functionalities in the films. As a result, both the amphiphilic block copolymer and the fluorinated polymer were mainly located in the cavities. Above a certain percentage of relative humidity, honeycomb structured films were obtained in which the block copolymer is distributed on the edge of the pore as a result of the affinity by the condensing water droplet and the coffee stain effect. The homopolymer is also preferentially situated at the pore edge, but forming spherical domains with narrow polydisperse sizes. Moreover, thiolated glucose molecules were specifically attached to the P5FS21 domains via thiol-para fluorine "click" reaction. Subsequently, the specific lectin (Concanavalin A, Canavalia ensiformis) was attached to the surface by conjugation with the glucose moieties. The successful binding of the Con A was demonstrated by the fluorescence, observed exclusively at the areas where P5FS21 domains are located. This nonlithographic method opens a new route to fabricate a huge variety of microstructured polymer films in terms of morphology not only for protein patterning, as illustrated in this manuscript, but also to produce a diversity of functional group arrangements. © 2013 American Chemical Society.This work was financially supported by the MINECO (Projects MAT2010-17016, MAT2010-21088-C03-01, and COST Action MP0904 SIMUFER). A M.-B. gratefully acknowledges the MINECO for her Juan de la Cierva postdoctoral contract and A.S.d.L. thanks the Ministerio de Educacion for his FPU ́ predoctoral fellowship.Peer reviewedAmerican Chemical SocietyMinisterio de Economía y Competitividad (España)Ministerio de Educación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420132024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/10261/343614reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//MAT2010-21088-C03-01http://dx.doi.org/10.1021/am400679rSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3436142026-05-22T06:33:51Z
dc.title.none.fl_str_mv Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry
title Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry
spellingShingle Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry
Sanz de León, Alberto
breath figures
Polymer blends
porous interfaces
click chemistry
phase separation
polymer surfaces
title_short Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry
title_full Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry
title_fullStr Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry
title_full_unstemmed Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry
title_sort Fabrication of structured porous films by breath figures and phase separation processes: Tuning the chemistry and morphology inside the pores using click chemistry
dc.creator.none.fl_str_mv Sanz de León, Alberto
Campo, Ángel Adolfo del
Fernández-García, Marta
Rodríguez-Hernández, Juan
Muñoz-Bonilla, Alexandra
author Sanz de León, Alberto
author_facet Sanz de León, Alberto
Campo, Ángel Adolfo del
Fernández-García, Marta
Rodríguez-Hernández, Juan
Muñoz-Bonilla, Alexandra
author_role author
author2 Campo, Ángel Adolfo del
Fernández-García, Marta
Rodríguez-Hernández, Juan
Muñoz-Bonilla, Alexandra
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Educación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv breath figures
Polymer blends
porous interfaces
click chemistry
phase separation
polymer surfaces
topic breath figures
Polymer blends
porous interfaces
click chemistry
phase separation
polymer surfaces
description Herein, a facile water-assisted templating technique, the so-called breath figures method, in combination with phase separation process, was employed to prepare multifunctional micropatterned films. Tetrahydrofuran solutions of incompatible ternary blends consisting of high-molecular-weight polystyrene, an amphiphilic block copolymer, polystyrene-b-poly[poly(ethylene glycol) methyl ether methacrylate] (PS40-b-P(PEGMA300)48), and a fluorinated homopolymer, poly(2,3,4,5,6-pentafluorostyrene) (P5FS21) were casted under humid atmosphere varying the proportion of the components. Two simultaneously occurring processes, i.e., the breath figures mechanism and the phase separation process, lead to unprecedented morphologies that could be tuned by simply varying the relative humidity or the composition of the blend. Confocal micro-Raman spectroscopy served to provide information about the location and distribution of the different functionalities in the films. As a result, both the amphiphilic block copolymer and the fluorinated polymer were mainly located in the cavities. Above a certain percentage of relative humidity, honeycomb structured films were obtained in which the block copolymer is distributed on the edge of the pore as a result of the affinity by the condensing water droplet and the coffee stain effect. The homopolymer is also preferentially situated at the pore edge, but forming spherical domains with narrow polydisperse sizes. Moreover, thiolated glucose molecules were specifically attached to the P5FS21 domains via thiol-para fluorine "click" reaction. Subsequently, the specific lectin (Concanavalin A, Canavalia ensiformis) was attached to the surface by conjugation with the glucose moieties. The successful binding of the Con A was demonstrated by the fluorescence, observed exclusively at the areas where P5FS21 domains are located. This nonlithographic method opens a new route to fabricate a huge variety of microstructured polymer films in terms of morphology not only for protein patterning, as illustrated in this manuscript, but also to produce a diversity of functional group arrangements. © 2013 American Chemical Society.
publishDate 2013
dc.date.none.fl_str_mv 2013
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/343614
url http://hdl.handle.net/10261/343614
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN//MAT2010-21088-C03-01
http://dx.doi.org/10.1021/am400679r
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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