Cortical microstructure in primary progressive aphasia
Background: Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes....
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:282270 |
| Acceso en línea: | https://ddd.uab.cat/record/282270 https://dx.doi.org/urn:doi:10.1186/s13195-022-00974-0 |
| Access Level: | acceso abierto |
| Palabra clave: | Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration |
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España |
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| dc.title.none.fl_str_mv |
Cortical microstructure in primary progressive aphasia a multicenter study |
| title |
Cortical microstructure in primary progressive aphasia |
| spellingShingle |
Cortical microstructure in primary progressive aphasia Illán-Gala, Ignacio|||0000-0002-5418-2052 Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration |
| title_short |
Cortical microstructure in primary progressive aphasia |
| title_full |
Cortical microstructure in primary progressive aphasia |
| title_fullStr |
Cortical microstructure in primary progressive aphasia |
| title_full_unstemmed |
Cortical microstructure in primary progressive aphasia |
| title_sort |
Cortical microstructure in primary progressive aphasia |
| dc.creator.none.fl_str_mv |
Illán-Gala, Ignacio|||0000-0002-5418-2052 Montal, Victor|||0000-0002-5714-9282 Borrego-Écija, Sergi|||0000-0003-2557-0010 Mandelli, Maria Luisa|||0000-0002-2518-2520 Falgàs, Neus|||0000-0002-3404-2765 Welch, Ariane E. Pegueroles, Jordi|||0000-0002-3554-2446 Santos Santos, Miguel Ángel|||0000-0003-1567-617X Bejanin, Alexandre|||0000-0002-9958-0951 Alcolea, Daniel|||0000-0002-3819-3245 Dols Icardo, Oriol|||0000-0003-2656-8748 Belbin, Olivia|||0000-0002-6109-6371 Sánchez-Saudinós, María Belén|||0000-0003-1795-1833 Bargalló, Núria|||0000-0001-6284-5402 González-Ortiz, Sofía|||0000-0003-2578-6671 Llado Plarrumani, Albert|||0000-0002-5066-4150 Blesa, Rafael|||0000-0003-4026-2884 Dickerson, Bradford C. Rosen, Howard J.|||0000-0001-9281-7402 Miller, Bruce L.|||0000-0002-2152-4220 Lleó, Alberto|||0000-0002-2568-5478 Gorno-Tempini, Maria Luisa Sanchez-Valle, Raquel|||0000-0001-7750-896X Fortea, Juan|||0000-0002-1340-638X |
| author |
Illán-Gala, Ignacio|||0000-0002-5418-2052 |
| author_facet |
Illán-Gala, Ignacio|||0000-0002-5418-2052 Montal, Victor|||0000-0002-5714-9282 Borrego-Écija, Sergi|||0000-0003-2557-0010 Mandelli, Maria Luisa|||0000-0002-2518-2520 Falgàs, Neus|||0000-0002-3404-2765 Welch, Ariane E. Pegueroles, Jordi|||0000-0002-3554-2446 Santos Santos, Miguel Ángel|||0000-0003-1567-617X Bejanin, Alexandre|||0000-0002-9958-0951 Alcolea, Daniel|||0000-0002-3819-3245 Dols Icardo, Oriol|||0000-0003-2656-8748 Belbin, Olivia|||0000-0002-6109-6371 Sánchez-Saudinós, María Belén|||0000-0003-1795-1833 Bargalló, Núria|||0000-0001-6284-5402 González-Ortiz, Sofía|||0000-0003-2578-6671 Llado Plarrumani, Albert|||0000-0002-5066-4150 Blesa, Rafael|||0000-0003-4026-2884 Dickerson, Bradford C. Rosen, Howard J.|||0000-0001-9281-7402 Miller, Bruce L.|||0000-0002-2152-4220 Lleó, Alberto|||0000-0002-2568-5478 Gorno-Tempini, Maria Luisa Sanchez-Valle, Raquel|||0000-0001-7750-896X Fortea, Juan|||0000-0002-1340-638X |
| author_role |
author |
| author2 |
Montal, Victor|||0000-0002-5714-9282 Borrego-Écija, Sergi|||0000-0003-2557-0010 Mandelli, Maria Luisa|||0000-0002-2518-2520 Falgàs, Neus|||0000-0002-3404-2765 Welch, Ariane E. Pegueroles, Jordi|||0000-0002-3554-2446 Santos Santos, Miguel Ángel|||0000-0003-1567-617X Bejanin, Alexandre|||0000-0002-9958-0951 Alcolea, Daniel|||0000-0002-3819-3245 Dols Icardo, Oriol|||0000-0003-2656-8748 Belbin, Olivia|||0000-0002-6109-6371 Sánchez-Saudinós, María Belén|||0000-0003-1795-1833 Bargalló, Núria|||0000-0001-6284-5402 González-Ortiz, Sofía|||0000-0003-2578-6671 Llado Plarrumani, Albert|||0000-0002-5066-4150 Blesa, Rafael|||0000-0003-4026-2884 Dickerson, Bradford C. Rosen, Howard J.|||0000-0001-9281-7402 Miller, Bruce L.|||0000-0002-2152-4220 Lleó, Alberto|||0000-0002-2568-5478 Gorno-Tempini, Maria Luisa Sanchez-Valle, Raquel|||0000-0001-7750-896X Fortea, Juan|||0000-0002-1340-638X |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration |
| topic |
Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration |
| description |
Background: Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA). Methods: In this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach. Results: The comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity. Conclusions: Cortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/282270 https://dx.doi.org/urn:doi:10.1186/s13195-022-00974-0 |
| url |
https://ddd.uab.cat/record/282270 https://dx.doi.org/urn:doi:10.1186/s13195-022-00974-0 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 JR20/0018 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FI18/00275 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP20/00038 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/01126 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01019 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/01532 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI16/01825 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00335 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 INT19/00016 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00435 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/01618 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00448 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01896 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01330 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 AC19:00103 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 PERISSLT002/16/00408 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-0235 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 PERISSLT006/17/125 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 PERISSLT006/17/00119 European Commission https://doi.org/10.13039/501100000780 965422 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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1869406560929710080 |
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Cortical microstructure in primary progressive aphasiaa multicenter studyIllán-Gala, Ignacio|||0000-0002-5418-2052Montal, Victor|||0000-0002-5714-9282Borrego-Écija, Sergi|||0000-0003-2557-0010Mandelli, Maria Luisa|||0000-0002-2518-2520Falgàs, Neus|||0000-0002-3404-2765Welch, Ariane E.Pegueroles, Jordi|||0000-0002-3554-2446Santos Santos, Miguel Ángel|||0000-0003-1567-617XBejanin, Alexandre|||0000-0002-9958-0951Alcolea, Daniel|||0000-0002-3819-3245Dols Icardo, Oriol|||0000-0003-2656-8748Belbin, Olivia|||0000-0002-6109-6371Sánchez-Saudinós, María Belén|||0000-0003-1795-1833Bargalló, Núria|||0000-0001-6284-5402González-Ortiz, Sofía|||0000-0003-2578-6671Llado Plarrumani, Albert|||0000-0002-5066-4150Blesa, Rafael|||0000-0003-4026-2884Dickerson, Bradford C.Rosen, Howard J.|||0000-0001-9281-7402Miller, Bruce L.|||0000-0002-2152-4220Lleó, Alberto|||0000-0002-2568-5478Gorno-Tempini, Maria LuisaSanchez-Valle, Raquel|||0000-0001-7750-896XFortea, Juan|||0000-0002-1340-638XDifusionMagnetic resonancePrimary progressive aphasiaAlzheimer's diseaseFrontotemporal lobar degenerationBackground: Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA). Methods: In this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach. Results: The comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity. Conclusions: Cortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/282270https://dx.doi.org/urn:doi:10.1186/s13195-022-00974-0reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 JR20/0018Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FI18/00275Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP20/00038Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/01126Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01019Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/01532Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI16/01825Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00335Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 INT19/00016Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00435Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/01618Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00448Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01896Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01330Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 AC19:00103Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 PERISSLT002/16/00408Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-0235Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 PERISSLT006/17/125Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 PERISSLT006/17/00119European Commission https://doi.org/10.13039/501100000780 965422open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2822702026-06-06T12:50:31Z |
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15,300724 |