Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator

Font Inglès, Joan|||0000-0001-8416-1909; López Cano, Marc|||0000-0001-8885-3726; Notartomaso, Serena|||0000-0003-4374-9233; Scarselli, Pamela|||0000-0002-4245-0849; Di Pietro, Paola|||0000-0003-1327-1961; Bresolí-Obach, Roger|||0000-0002-7819-7750; Battaglia, Giuseppe|||0000-0001-7571-3417; Malhaire, Fanny; Rovira, Xavier|||0000-0002-9764-9927; Catena, Juanlo|||0000-0002-2423-5926; Giraldo, Jesús|||0000-0001-7082-4695; Pin, Jean-Philippe|||0000-0002-1423-345X; Fernández-Dueñas, Víctor|||0000-0001-7834-2965; Goudet, Cyril|||0000-0002-8255-3535; Nonell, Santi|||0000-0002-8900-5291; Nicoletti, Ferdinando|||0000-0003-0917-443X; Llebaria, Amadeu|||0000-0002-8200-4827; Ciruela, Francisco|||0000-0003-0832-3739

Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator

Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu) receptor negative allosteric modulat...

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Autores:	Font Inglès, Joan\|\|\|0000-0001-8416-1909, López Cano, Marc\|\|\|0000-0001-8885-3726, Notartomaso, Serena\|\|\|0000-0003-4374-9233, Scarselli, Pamela\|\|\|0000-0002-4245-0849, Di Pietro, Paola\|\|\|0000-0003-1327-1961, Bresolí-Obach, Roger\|\|\|0000-0002-7819-7750, Battaglia, Giuseppe\|\|\|0000-0001-7571-3417, Malhaire, Fanny, Rovira, Xavier\|\|\|0000-0002-9764-9927, Catena, Juanlo\|\|\|0000-0002-2423-5926, Giraldo, Jesús\|\|\|0000-0001-7082-4695, Pin, Jean-Philippe\|\|\|0000-0002-1423-345X, Fernández-Dueñas, Víctor\|\|\|0000-0001-7834-2965, Goudet, Cyril\|\|\|0000-0002-8255-3535, Nonell, Santi\|\|\|0000-0002-8900-5291, Nicoletti, Ferdinando\|\|\|0000-0003-0917-443X, Llebaria, Amadeu\|\|\|0000-0002-8200-4827, Ciruela, Francisco\|\|\|0000-0003-0832-3739
Tipo de recurso:	artículo
Fecha de publicación:	2017
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:186204
Acceso en línea:	https://ddd.uab.cat/record/186204 https://dx.doi.org/urn:doi:10.7554/eLife.23545
Access Level:	acceso abierto
Palabra clave:	Analgesia Optopharmacology Pain neuraxis Mglu5 receptor Allosteric modulation Mouse

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repository_id_str
spelling	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulatorFont Inglès, Joan\|\|\|0000-0001-8416-1909López Cano, Marc\|\|\|0000-0001-8885-3726Notartomaso, Serena\|\|\|0000-0003-4374-9233Scarselli, Pamela\|\|\|0000-0002-4245-0849Di Pietro, Paola\|\|\|0000-0003-1327-1961Bresolí-Obach, Roger\|\|\|0000-0002-7819-7750Battaglia, Giuseppe\|\|\|0000-0001-7571-3417Malhaire, FannyRovira, Xavier\|\|\|0000-0002-9764-9927Catena, Juanlo\|\|\|0000-0002-2423-5926Giraldo, Jesús\|\|\|0000-0001-7082-4695Pin, Jean-Philippe\|\|\|0000-0002-1423-345XFernández-Dueñas, Víctor\|\|\|0000-0001-7834-2965Goudet, Cyril\|\|\|0000-0002-8255-3535Nonell, Santi\|\|\|0000-0002-8900-5291Nicoletti, Ferdinando\|\|\|0000-0003-0917-443XLlebaria, Amadeu\|\|\|0000-0002-8200-4827Ciruela, Francisco\|\|\|0000-0003-0832-3739AnalgesiaOptopharmacologyPain neuraxisMglu5 receptorAllosteric modulationMouseLight-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu) receptor negative allosteric modulator raseglurant. Violet light illumination of JF-NP-26 induces a photochemical reaction prompting the active-drug's release, which effectively controls mGlu receptor activity both in ectopic expressing systems and in striatal primary neurons. Systemic administration in mice followed by local light-emitting diode (LED)-based illumination, either of the thalamus or the peripheral tissues, induced JF-NP-26-mediated light-dependent analgesia both in neuropathic and in acute/tonic inflammatory pain models. These data offer the first example of optical control of analgesia in vivo using a photocaged mGlu receptor negative allosteric modulator. This approach shows potential for precisely targeting, in time and space, endogenous receptors, which may allow a better management of difficult-to-treat disorders. 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186204https://dx.doi.org/urn:doi:10.7554/eLife.23545reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2014-55700-PMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PCIN-2013-019-C03-03Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PIE14-00034Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-1054European Commission https://doi.org/10.13039/501100000780 ANR-12-NEUR-0003-05open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1862042026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator
title	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator
spellingShingle	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator Font Inglès, Joan\|\|\|0000-0001-8416-1909 Analgesia Optopharmacology Pain neuraxis Mglu5 receptor Allosteric modulation Mouse
title_short	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator
title_full	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator
title_fullStr	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator
title_full_unstemmed	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator
title_sort	Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator
dc.creator.none.fl_str_mv	Font Inglès, Joan\|\|\|0000-0001-8416-1909 López Cano, Marc\|\|\|0000-0001-8885-3726 Notartomaso, Serena\|\|\|0000-0003-4374-9233 Scarselli, Pamela\|\|\|0000-0002-4245-0849 Di Pietro, Paola\|\|\|0000-0003-1327-1961 Bresolí-Obach, Roger\|\|\|0000-0002-7819-7750 Battaglia, Giuseppe\|\|\|0000-0001-7571-3417 Malhaire, Fanny Rovira, Xavier\|\|\|0000-0002-9764-9927 Catena, Juanlo\|\|\|0000-0002-2423-5926 Giraldo, Jesús\|\|\|0000-0001-7082-4695 Pin, Jean-Philippe\|\|\|0000-0002-1423-345X Fernández-Dueñas, Víctor\|\|\|0000-0001-7834-2965 Goudet, Cyril\|\|\|0000-0002-8255-3535 Nonell, Santi\|\|\|0000-0002-8900-5291 Nicoletti, Ferdinando\|\|\|0000-0003-0917-443X Llebaria, Amadeu\|\|\|0000-0002-8200-4827 Ciruela, Francisco\|\|\|0000-0003-0832-3739
author	Font Inglès, Joan\|\|\|0000-0001-8416-1909
author_facet	Font Inglès, Joan\|\|\|0000-0001-8416-1909 López Cano, Marc\|\|\|0000-0001-8885-3726 Notartomaso, Serena\|\|\|0000-0003-4374-9233 Scarselli, Pamela\|\|\|0000-0002-4245-0849 Di Pietro, Paola\|\|\|0000-0003-1327-1961 Bresolí-Obach, Roger\|\|\|0000-0002-7819-7750 Battaglia, Giuseppe\|\|\|0000-0001-7571-3417 Malhaire, Fanny Rovira, Xavier\|\|\|0000-0002-9764-9927 Catena, Juanlo\|\|\|0000-0002-2423-5926 Giraldo, Jesús\|\|\|0000-0001-7082-4695 Pin, Jean-Philippe\|\|\|0000-0002-1423-345X Fernández-Dueñas, Víctor\|\|\|0000-0001-7834-2965 Goudet, Cyril\|\|\|0000-0002-8255-3535 Nonell, Santi\|\|\|0000-0002-8900-5291 Nicoletti, Ferdinando\|\|\|0000-0003-0917-443X Llebaria, Amadeu\|\|\|0000-0002-8200-4827 Ciruela, Francisco\|\|\|0000-0003-0832-3739
author_role	author
author2	López Cano, Marc\|\|\|0000-0001-8885-3726 Notartomaso, Serena\|\|\|0000-0003-4374-9233 Scarselli, Pamela\|\|\|0000-0002-4245-0849 Di Pietro, Paola\|\|\|0000-0003-1327-1961 Bresolí-Obach, Roger\|\|\|0000-0002-7819-7750 Battaglia, Giuseppe\|\|\|0000-0001-7571-3417 Malhaire, Fanny Rovira, Xavier\|\|\|0000-0002-9764-9927 Catena, Juanlo\|\|\|0000-0002-2423-5926 Giraldo, Jesús\|\|\|0000-0001-7082-4695 Pin, Jean-Philippe\|\|\|0000-0002-1423-345X Fernández-Dueñas, Víctor\|\|\|0000-0001-7834-2965 Goudet, Cyril\|\|\|0000-0002-8255-3535 Nonell, Santi\|\|\|0000-0002-8900-5291 Nicoletti, Ferdinando\|\|\|0000-0003-0917-443X Llebaria, Amadeu\|\|\|0000-0002-8200-4827 Ciruela, Francisco\|\|\|0000-0003-0832-3739
author2_role	author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Analgesia Optopharmacology Pain neuraxis Mglu5 receptor Allosteric modulation Mouse
topic	Analgesia Optopharmacology Pain neuraxis Mglu5 receptor Allosteric modulation Mouse
description	Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu) receptor negative allosteric modulator raseglurant. Violet light illumination of JF-NP-26 induces a photochemical reaction prompting the active-drug's release, which effectively controls mGlu receptor activity both in ectopic expressing systems and in striatal primary neurons. Systemic administration in mice followed by local light-emitting diode (LED)-based illumination, either of the thalamus or the peripheral tissues, induced JF-NP-26-mediated light-dependent analgesia both in neuropathic and in acute/tonic inflammatory pain models. These data offer the first example of optical control of analgesia in vivo using a photocaged mGlu receptor negative allosteric modulator. This approach shows potential for precisely targeting, in time and space, endogenous receptors, which may allow a better management of difficult-to-treat disorders.
publishDate	2017
dc.date.none.fl_str_mv	2 2017-01-01 2017 2017-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/186204 https://dx.doi.org/urn:doi:10.7554/eLife.23545
url	https://ddd.uab.cat/record/186204 https://dx.doi.org/urn:doi:10.7554/eLife.23545
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2014-55700-P Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PCIN-2013-019-C03-03 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PIE14-00034 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-1054 European Commission https://doi.org/10.13039/501100000780 ANR-12-NEUR-0003-05
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,300719

Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator

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