Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures

Prior studies have described distinct patterns of brain gray matter and white matter alterations in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), as well as differences in their cerebrospinal fluid (CSF) biomarkers profiles. We aim to investigate the relationship betwee...

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Bibliographic Details
Authors: Falgàs Martínez, Neus, Ruiz Peris, Mariona, Pérez Millan, Agnès, Sala Llonch, Roser, Antonell Boixader, Anna, 1978-, Balasa, Mircea, Borrego Écija, Sergi, Ramos Campoy, Oscar, Augé Fradera, Josep Maria, Castellví, Magdalena, Tort Merino, Adrià, Olives, Jaume, Fernández Villullas, Guadalupe, Blennow, Kaj, Zetterberg, Henrik, Bargalló Alabart, Núria, Lladó Plarrumaní, Albert, Sánchez del Valle Díaz, Raquel
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176636
Online Access:https://hdl.handle.net/2445/176636
Access Level:Open access
Keyword:Malaltia d'Alzheimer
Degeneració
Líquid cefalorraquidi
Alzheimer's disease
Degeneration
Cerebrospinal fluid
Description
Summary:Prior studies have described distinct patterns of brain gray matter and white matter alterations in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), as well as differences in their cerebrospinal fluid (CSF) biomarkers profiles. We aim to investigate the relationship between early‐onset AD (EOAD) and FTLD structural alterations and CSF biomarker levels. We included 138 subjects (64 EOAD, 26 FTLD, and 48 controls), all of them with a 3T MRI brain scan and CSF biomarkers available (the 42 amino acid‐long form of the amyloid‐beta protein [Aβ42], total‐tau protein [T‐tau], neurofilament light chain [NfL], neurogranin [Ng], and 14‐3‐3 levels). We used FreeSurfer and FSL to obtain cortical thickness (CTh) and fraction anisotropy (FA) maps. We studied group differences in CTh and FA and described the "AD signature" and "FTLD signature." We tested multiple regression models to find which CSF‐biomarkers better explained each disease neuroimaging signature. CTh and FA maps corresponding to the AD and FTLD signatures were in accordance with previous literature. Multiple regression analyses showed that the biomarkers that better explained CTh values within the AD signature were Aβ and 14‐3‐3; whereas NfL and 14‐3‐3 levels explained CTh values within the FTLD signature. Similarly, NfL levels explained FA values in the FTLD signature. Ng levels were not predictive in any of the models. Biochemical markers contribute differently to structural (CTh and FA) changes typical of AD and FTLD.

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