Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects

Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed the association between epigenetic biomarkers of aging and depressive symptoms. Similarly, limited research has examined the joint effects of...

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Autores: Sorlí, José Vicente, Cámara, Edurne de la, Fernández-Carrión, Rebeca, Asensio, Eva M., Portolés, Olga, Ortega-Azorín, Carolina, Pérez-Fidalgo, Alejandro, Villamil, Laura V., Fitó Colomer, Montserrat, Barragán, Rocío, Coltell, Oscar, Corella, Dolores
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/72519
Acesso em linha:https://hdl.handle.net/10230/72519
http://dx.doi.org/10.3390/nu17010104
Access Level:acceso abierto
Palavra-chave:Aging
Chronic diseases
Chronotype
Depression
Mediterranean diet
Mental health
Methylation clocks
Nutrition
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spelling Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjectsSorlí, José VicenteCámara, Edurne de laFernández-Carrión, RebecaAsensio, Eva M.Portolés, OlgaOrtega-Azorín, CarolinaPérez-Fidalgo, AlejandroVillamil, Laura V.Fitó Colomer, MontserratBarragán, RocíoColtell, OscarCorella, DoloresAgingChronic diseasesChronotypeDepressionMediterranean dietMental healthMethylation clocksNutritionBackground and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed the association between epigenetic biomarkers of aging and depressive symptoms. Similarly, limited research has examined the joint effects of adherence to the Mediterranean diet (MedDiet) and chronotype on depressive symptoms, accounting for sex differences. Therefore, these are the objectives of our investigation in a Mediterranean population at high cardiovascular risk. Methods: We analyzed 465 older subjects (aged 55-75) with metabolic syndrome and assessed depressive symptoms by the Beck Depression Inventory (BDI-II). MedDiet adherence was measured with the 17-item MedDiet score, and chronotype with the Morningness-Eveningness Questionnaire (MEQ). Blood DNA methylation was analyzed, and epigenomic biomarkers of age acceleration were determined. We focused on the Dunedin Pace of Aging Computed from the Epigenome (DunedinPACE). We fitted multivariable models with interaction terms. Results: Prevalence of depression was statistically higher in women (p < 0.001). MedDiet adherence was strongly and inversely associated with depressive symptoms in the whole population (p < 0.01), while the MEQ score was inversely associated (p < 0.05). In the joint analysis, both MedDiet adherence and chronotype remained statistically associated with the BDI-II score (p < 0.05), showing additive effects. No interaction effects were observed. In women, a higher score in depressive symptoms was significantly associated with faster age acceleration (measured with the DunedinPACE biomarker). This association remained significant even after adjustment for MedDiet adherence and chronotype. Conclusions: In older subjects with metabolic syndrome, the eveningness chronotype was associated with greater depressive symptoms, but a higher adherence to the MedDiet could potentially counteract the chronotype risk with additive effects. Women showed stronger associations, and importantly, we reported for the first time in this population that depressive symptoms were associated with accelerated aging.This study was partially funded by the Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER) (grants CIBER 06/03, SAF2016-80532-R, PI13/00728, PI16/00366 and PI19/00781); the Generalitat Valenciana (grants PROMETEO2017/017, PROMETEO/2021/021; Programa Santiago Grisolía nº CIGRIS/2022/082); grant PID2019-108858RB-I00 funded by AEI 10.13039/501100011033 and by "ERDF A way of making Europe", and the Ministerio de Ciencia, Innovación y Universidades-AEI (grant PID2023-150110OB-I00).MDPI2026202620242026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/72519http://dx.doi.org/10.3390/nu17010104reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNutrients. 2024;17(1):104info:eu-repo/grantAgreement/ES/1PE/SAF2016-80532-Rinfo:eu-repo/grantAgreement/ES/2PE/PID2019-108858RB-I00info:eu-repo/grantAgreement/ES/3PE/PID2023-150110OB-I00© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/725192026-06-12T07:21:37Z
dc.title.none.fl_str_mv Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects
title Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects
spellingShingle Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects
Sorlí, José Vicente
Aging
Chronic diseases
Chronotype
Depression
Mediterranean diet
Mental health
Methylation clocks
Nutrition
title_short Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects
title_full Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects
title_fullStr Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects
title_full_unstemmed Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects
title_sort Depression and accelerated aging: the eveningness chronotype and low adherence to the mediterranean diet are associated with depressive symptoms in older subjects
dc.creator.none.fl_str_mv Sorlí, José Vicente
Cámara, Edurne de la
Fernández-Carrión, Rebeca
Asensio, Eva M.
Portolés, Olga
Ortega-Azorín, Carolina
Pérez-Fidalgo, Alejandro
Villamil, Laura V.
Fitó Colomer, Montserrat
Barragán, Rocío
Coltell, Oscar
Corella, Dolores
author Sorlí, José Vicente
author_facet Sorlí, José Vicente
Cámara, Edurne de la
Fernández-Carrión, Rebeca
Asensio, Eva M.
Portolés, Olga
Ortega-Azorín, Carolina
Pérez-Fidalgo, Alejandro
Villamil, Laura V.
Fitó Colomer, Montserrat
Barragán, Rocío
Coltell, Oscar
Corella, Dolores
author_role author
author2 Cámara, Edurne de la
Fernández-Carrión, Rebeca
Asensio, Eva M.
Portolés, Olga
Ortega-Azorín, Carolina
Pérez-Fidalgo, Alejandro
Villamil, Laura V.
Fitó Colomer, Montserrat
Barragán, Rocío
Coltell, Oscar
Corella, Dolores
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Aging
Chronic diseases
Chronotype
Depression
Mediterranean diet
Mental health
Methylation clocks
Nutrition
topic Aging
Chronic diseases
Chronotype
Depression
Mediterranean diet
Mental health
Methylation clocks
Nutrition
description Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed the association between epigenetic biomarkers of aging and depressive symptoms. Similarly, limited research has examined the joint effects of adherence to the Mediterranean diet (MedDiet) and chronotype on depressive symptoms, accounting for sex differences. Therefore, these are the objectives of our investigation in a Mediterranean population at high cardiovascular risk. Methods: We analyzed 465 older subjects (aged 55-75) with metabolic syndrome and assessed depressive symptoms by the Beck Depression Inventory (BDI-II). MedDiet adherence was measured with the 17-item MedDiet score, and chronotype with the Morningness-Eveningness Questionnaire (MEQ). Blood DNA methylation was analyzed, and epigenomic biomarkers of age acceleration were determined. We focused on the Dunedin Pace of Aging Computed from the Epigenome (DunedinPACE). We fitted multivariable models with interaction terms. Results: Prevalence of depression was statistically higher in women (p < 0.001). MedDiet adherence was strongly and inversely associated with depressive symptoms in the whole population (p < 0.01), while the MEQ score was inversely associated (p < 0.05). In the joint analysis, both MedDiet adherence and chronotype remained statistically associated with the BDI-II score (p < 0.05), showing additive effects. No interaction effects were observed. In women, a higher score in depressive symptoms was significantly associated with faster age acceleration (measured with the DunedinPACE biomarker). This association remained significant even after adjustment for MedDiet adherence and chronotype. Conclusions: In older subjects with metabolic syndrome, the eveningness chronotype was associated with greater depressive symptoms, but a higher adherence to the MedDiet could potentially counteract the chronotype risk with additive effects. Women showed stronger associations, and importantly, we reported for the first time in this population that depressive symptoms were associated with accelerated aging.
publishDate 2024
dc.date.none.fl_str_mv 2024
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/72519
http://dx.doi.org/10.3390/nu17010104
url https://hdl.handle.net/10230/72519
http://dx.doi.org/10.3390/nu17010104
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nutrients. 2024;17(1):104
info:eu-repo/grantAgreement/ES/1PE/SAF2016-80532-R
info:eu-repo/grantAgreement/ES/2PE/PID2019-108858RB-I00
info:eu-repo/grantAgreement/ES/3PE/PID2023-150110OB-I00
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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