Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients
Producción Científica
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Valladolid |
| Repositorio: | UVaDOC. Repositorio Documental de la Universidad de Valladolid |
| OAI Identifier: | oai:uvadoc.uva.es:10324/45485 |
| Acceso en línea: | https://doi.org/10.1038/s41598-018-30505-7 http://uvadoc.uva.es/handle/10324/45485 |
| Access Level: | acceso abierto |
| Palabra clave: | Procalcitonin Procalcitonina HLA-DR Sepsis 3213 Cirugía |
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Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patientsAlmansa Mora, RaquelMartín, SilviaMartín Fernández, MartaHeredia Rodríguez, MaríaGómez Sánchez, EstherAragón, MartaAndrés Iglesias, CristinaCalvo, DoloresRico Feijoo, JesúsEsteban Velasco, María CarmenVaquero Roncero, Luis MarioOrtega, AliciaGómez Pesquera, EstefaníaLorenzo López, MarioLópez de Cenarruzabeitia, ÍñigoBenavides, DianaLópez Sánchez, JaimeDoncel, CristinaGonzález Sánchez, CarmenZarca, EstherRíos Llorente, AlbertoDíaz, AgustínSánchez Barrado, ElisaBeltrán de Heredia Rentería, JuanCalvo Vecino, José MaríaMuñoz Bellvís, LuisGómez Herreras, José IgnacioAldecoa Álvarez Santullano, César EnriqueTamayo Gómez, EduardoBermejo Martín, Jesús FranciscoProcalcitoninProcalcitoninaHLA-DRSepsis3213 CirugíaProducción CientíficaEarly recognition of sepsis is a key factor to improve survival to this disease in surgical patients, since it allows prompt control of the infectious source. Combining pro-infammatory and immunosupression biomarkers could represent a good strategy to improve sepsis detection. Here we evaluated the combination of procalcitonin (PCT) with gene expression levels of HLA-DRA to detect sepsis in a cohort of 154 surgical patients (101 with sepsis and 53 with no infection). HLA-DRA expression was quantifed using droplet digital PCR, a next-generation PCR technology. Area under the receiver operating curve analysis (AUROC) showed that the PCT/HLA-DRA ratio outperformed PCT to detect sepsis (AUROC [CI95%], p): PCT: 0.80 [0.73–0.88], <0.001; PCT/HLA-DRA: 0.85 [0.78–0.91], <0.001. In the multivariate analysis, the ratio showed a superior ability to predict sepsis compared to that of PCT (OR [CI 95%], p): PCT/HLA-DRA: 7.66 [1.82–32.29], 0.006; PCT: 4.21 [1.15–15.43] 0.030. Multivariate analysis was confrmed using a new surgical cohort with 74 sepsis patients and 21 controls: PCT/HLADRA: 34.86 [1.22–995.08], 0.038; PCT: 5.52 [0.40–75.78], 0.201. In conclusion, the combination of PCT with HLA-DRA is a promising strategy for improving sepsis detection in surgical patients.Instituto de Salud Carlos III - Consejeria de Sanidad de Castilla y Leon (grants EMER 07/050, PI15/01451 and PI16/01156)Springer Nature2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1038/s41598-018-30505-7http://uvadoc.uva.es/handle/10324/45485reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.nature.com/articles/s41598-018-30505-7info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/454852026-06-13T12:44:47Z |
| dc.title.none.fl_str_mv |
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients |
| title |
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients |
| spellingShingle |
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients Almansa Mora, Raquel Procalcitonin Procalcitonina HLA-DR Sepsis 3213 Cirugía |
| title_short |
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients |
| title_full |
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients |
| title_fullStr |
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients |
| title_full_unstemmed |
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients |
| title_sort |
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients |
| dc.creator.none.fl_str_mv |
Almansa Mora, Raquel Martín, Silvia Martín Fernández, Marta Heredia Rodríguez, María Gómez Sánchez, Esther Aragón, Marta Andrés Iglesias, Cristina Calvo, Dolores Rico Feijoo, Jesús Esteban Velasco, María Carmen Vaquero Roncero, Luis Mario Ortega, Alicia Gómez Pesquera, Estefanía Lorenzo López, Mario López de Cenarruzabeitia, Íñigo Benavides, Diana López Sánchez, Jaime Doncel, Cristina González Sánchez, Carmen Zarca, Esther Ríos Llorente, Alberto Díaz, Agustín Sánchez Barrado, Elisa Beltrán de Heredia Rentería, Juan Calvo Vecino, José María Muñoz Bellvís, Luis Gómez Herreras, José Ignacio Aldecoa Álvarez Santullano, César Enrique Tamayo Gómez, Eduardo Bermejo Martín, Jesús Francisco |
| author |
Almansa Mora, Raquel |
| author_facet |
Almansa Mora, Raquel Martín, Silvia Martín Fernández, Marta Heredia Rodríguez, María Gómez Sánchez, Esther Aragón, Marta Andrés Iglesias, Cristina Calvo, Dolores Rico Feijoo, Jesús Esteban Velasco, María Carmen Vaquero Roncero, Luis Mario Ortega, Alicia Gómez Pesquera, Estefanía Lorenzo López, Mario López de Cenarruzabeitia, Íñigo Benavides, Diana López Sánchez, Jaime Doncel, Cristina González Sánchez, Carmen Zarca, Esther Ríos Llorente, Alberto Díaz, Agustín Sánchez Barrado, Elisa Beltrán de Heredia Rentería, Juan Calvo Vecino, José María Muñoz Bellvís, Luis Gómez Herreras, José Ignacio Aldecoa Álvarez Santullano, César Enrique Tamayo Gómez, Eduardo Bermejo Martín, Jesús Francisco |
| author_role |
author |
| author2 |
Martín, Silvia Martín Fernández, Marta Heredia Rodríguez, María Gómez Sánchez, Esther Aragón, Marta Andrés Iglesias, Cristina Calvo, Dolores Rico Feijoo, Jesús Esteban Velasco, María Carmen Vaquero Roncero, Luis Mario Ortega, Alicia Gómez Pesquera, Estefanía Lorenzo López, Mario López de Cenarruzabeitia, Íñigo Benavides, Diana López Sánchez, Jaime Doncel, Cristina González Sánchez, Carmen Zarca, Esther Ríos Llorente, Alberto Díaz, Agustín Sánchez Barrado, Elisa Beltrán de Heredia Rentería, Juan Calvo Vecino, José María Muñoz Bellvís, Luis Gómez Herreras, José Ignacio Aldecoa Álvarez Santullano, César Enrique Tamayo Gómez, Eduardo Bermejo Martín, Jesús Francisco |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Procalcitonin Procalcitonina HLA-DR Sepsis 3213 Cirugía |
| topic |
Procalcitonin Procalcitonina HLA-DR Sepsis 3213 Cirugía |
| description |
Producción Científica |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://doi.org/10.1038/s41598-018-30505-7 http://uvadoc.uva.es/handle/10324/45485 |
| url |
https://doi.org/10.1038/s41598-018-30505-7 http://uvadoc.uva.es/handle/10324/45485 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
| dc.relation.none.fl_str_mv |
https://www.nature.com/articles/s41598-018-30505-7 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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application/pdf |
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Springer Nature |
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Springer Nature |
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