Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn's Disease

Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn's disease (CD), yet one-third of patients fail to benefit from this treatment. Patients with CD develop a characteristic wrapping of visceral adipose tissue (VAT) in the inflamed intestinal area,...

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Authors: Boronat-Toscano, Albert|||0000-0003-2650-156X, Monfort-Ferré, Diandra|||0000-0003-3832-4249, Menacho, Margarita, Caro, Aleidis|||0000-0001-6151-3879, Bosch Príncep, Ramon|||0000-0003-4104-5515, Espina Perez, Beatriz|||0000-0003-1697-9973, Algaba, Ferran|||0000-0002-0071-4164, Saera-Vila, Alfonso, Moliné, Alicia, Marti-Gallostra, Marc|||0000-0002-0783-6359, Espin-Basany, Eloy|||0000-0002-9139-4548, Millan, Mónica, Serena, Carolina|||0000-0003-2251-0856
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:267043
Online Access:https://ddd.uab.cat/record/267043
https://dx.doi.org/urn:doi:10.3390/ijms231911170
Access Level:Open access
Keyword:Adipose tissue
Infliximab
Adalimumab
TNF
Creeping fat
Description
Summary:Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn's disease (CD), yet one-third of patients fail to benefit from this treatment. Patients with CD develop a characteristic wrapping of visceral adipose tissue (VAT) in the inflamed intestinal area, termed creeping fat, and it is known that adipose tissue expansion influences the efficacy of anti-TNF drugs. We questioned whether anti-TNF therapies impact the creeping fat in CD, which might affect the outcome of the disease. Adipose tissue biopsies were obtained from a cohort of 14 patients with CD that received anti-TNF drugs and from 29 non-anti-TNF-treated patients (control group) matched by sex, age, and body mass index undergoing surgical interventions for symptomatic complications. We found that anti-TNF therapies restored adipose tissue morphology and suppressed immune cell infiltration in the creeping fat. Additionally, anti-TNF treatments appeared to markedly improve the pro-inflammatory phenotype of adipose-tissue macrophages and adipose-tissue-derived stem cells. Our study provides evidence that anti-TNF medications influence immune cells and progenitor cells in the creeping of patients with CD, suppressing inflammation. We propose that perilesional VAT should be considered when administering anti-TNF therapy in patients with CD.

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