Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry

Objectives. To compare clinical features, laboratory data and fetal-maternal outcomes between 1000 women with obstetric APS (OAPS) and 640 with aPL-related obstetric complications not fulfilling Sydney criteria (non-criteria OAPS, NC-OAPS). Methods. This was a retrospective and prospective multicent...

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Autores: Alijotas-Reig, J, Esteve-Valverde, E, Ferrer-Oliveras, R, Saez-Comet, L, Lefkou, E, Mekinian, A, Belizna, C, Ruffatti, A, Hoxha, A, Tincani, A, Nalli, C, Marozio, L, Maina, A, Espinosa, G, Rios-Garces, R, Cervera, R, De Carolis, S, Monteleone, G, Latino, O, Udry, S, Llurba, E, Garrido-Gimenez, C, Trespidi, L, Gerosa, M, Chighizola, CB, Rovere-Querini, P, Canti, V, Mayer-Pickel, K, Tabacco, S, Arnau, A, Trape, J, Ruiz-Hidalgo, D, Sos, L, Farran-Codina, I, EUROAPS Study Grp
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p1912
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1912
Access Level:acceso abierto
Palavra-chave:antiphospholipid syndrome
antiphospholipid
antiphospholipid antibodies
non-criteria antiphospholipid syndrome
obstetric antiphospholipid syndrome
treatment
outcomes
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spelling Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registryAlijotas-Reig, JEsteve-Valverde, EFerrer-Oliveras, RSaez-Comet, LLefkou, EMekinian, ABelizna, CRuffatti, AHoxha, ATincani, ANalli, CMarozio, LMaina, AEspinosa, GRios-Garces, RCervera, RDe Carolis, SMonteleone, GLatino, OUdry, SLlurba, EGarrido-Gimenez, CTrespidi, LGerosa, MChighizola, CBRovere-Querini, PCanti, VMayer-Pickel, KTabacco, SArnau, ATrape, JRuiz-Hidalgo, DSos, LFarran-Codina, IEUROAPS Study Grpantiphospholipid syndromeantiphospholipidantiphospholipid antibodiesnon-criteria antiphospholipid syndromeobstetric antiphospholipid syndrometreatmentoutcomesObjectives. To compare clinical features, laboratory data and fetal-maternal outcomes between 1000 women with obstetric APS (OAPS) and 640 with aPL-related obstetric complications not fulfilling Sydney criteria (non-criteria OAPS, NC-OAPS). Methods. This was a retrospective and prospective multicentre study from the European Registry on Obstetric Antiphospholipid Syndrome. Results. A total of 1650 women with 5251 episodes, 3601 of which were historical and 1650 latest episodes, were included. Altogether, 1000 cases (OAPS group) fulfilled the Sydney classification criteria and 650 (NC-OAPS group) did not. Ten NC-OAPS cases were excluded for presenting thrombosis during follow-up. All cases were classified as category I (triple positivity or double positivity for aPL) or category II (simple positivity). Overall, aPL laboratory categories showed significant differences: 29.20% in OAPS vs 17.96% in NC-OAPS (P < 0.0001) for category I, and 70.8% in OAPS vs 82% in NC-OAPS (P < 0.0001) for category II. Significant differences were observed when current obstetric complications were compared (P < 0.001). However, major differences between groups were not observed in treatment rates, livebirths and thrombotic complications. In the NC-OAPS group, 176/640 (27.5%) did not fulfil Sydney clinical criteria (subgroup A), 175/640 (27.34%) had a low titre and/or non-persistent aPL positivity but did meet the clinical criteria (subgroup B) and 289/640 (45.15%) had a high aPL titre but did not fulfil Sydney clinical criteria (subgroup C). Conclusion. Significant clinical and laboratory differences were found between groups. Fetal-maternal outcomes were similar in both groups when treated. These results suggest that we could improve our clinical practice with better understanding of NC-OAPS patients.OXFORD UNIV PRESS2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1912RHEUMATOLOGYISSN: 14620324ISSNe: 14620332reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p19122026-06-14T12:41:47Z
dc.title.none.fl_str_mv Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry
title Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry
spellingShingle Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry
Alijotas-Reig, J
antiphospholipid syndrome
antiphospholipid
antiphospholipid antibodies
non-criteria antiphospholipid syndrome
obstetric antiphospholipid syndrome
treatment
outcomes
title_short Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry
title_full Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry
title_fullStr Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry
title_full_unstemmed Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry
title_sort Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry
dc.creator.none.fl_str_mv Alijotas-Reig, J
Esteve-Valverde, E
Ferrer-Oliveras, R
Saez-Comet, L
Lefkou, E
Mekinian, A
Belizna, C
Ruffatti, A
Hoxha, A
Tincani, A
Nalli, C
Marozio, L
Maina, A
Espinosa, G
Rios-Garces, R
Cervera, R
De Carolis, S
Monteleone, G
Latino, O
Udry, S
Llurba, E
Garrido-Gimenez, C
Trespidi, L
Gerosa, M
Chighizola, CB
Rovere-Querini, P
Canti, V
Mayer-Pickel, K
Tabacco, S
Arnau, A
Trape, J
Ruiz-Hidalgo, D
Sos, L
Farran-Codina, I
EUROAPS Study Grp
author Alijotas-Reig, J
author_facet Alijotas-Reig, J
Esteve-Valverde, E
Ferrer-Oliveras, R
Saez-Comet, L
Lefkou, E
Mekinian, A
Belizna, C
Ruffatti, A
Hoxha, A
Tincani, A
Nalli, C
Marozio, L
Maina, A
Espinosa, G
Rios-Garces, R
Cervera, R
De Carolis, S
Monteleone, G
Latino, O
Udry, S
Llurba, E
Garrido-Gimenez, C
Trespidi, L
Gerosa, M
Chighizola, CB
Rovere-Querini, P
Canti, V
Mayer-Pickel, K
Tabacco, S
Arnau, A
Trape, J
Ruiz-Hidalgo, D
Sos, L
Farran-Codina, I
EUROAPS Study Grp
author_role author
author2 Esteve-Valverde, E
Ferrer-Oliveras, R
Saez-Comet, L
Lefkou, E
Mekinian, A
Belizna, C
Ruffatti, A
Hoxha, A
Tincani, A
Nalli, C
Marozio, L
Maina, A
Espinosa, G
Rios-Garces, R
Cervera, R
De Carolis, S
Monteleone, G
Latino, O
Udry, S
Llurba, E
Garrido-Gimenez, C
Trespidi, L
Gerosa, M
Chighizola, CB
Rovere-Querini, P
Canti, V
Mayer-Pickel, K
Tabacco, S
Arnau, A
Trape, J
Ruiz-Hidalgo, D
Sos, L
Farran-Codina, I
EUROAPS Study Grp
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv antiphospholipid syndrome
antiphospholipid
antiphospholipid antibodies
non-criteria antiphospholipid syndrome
obstetric antiphospholipid syndrome
treatment
outcomes
topic antiphospholipid syndrome
antiphospholipid
antiphospholipid antibodies
non-criteria antiphospholipid syndrome
obstetric antiphospholipid syndrome
treatment
outcomes
description Objectives. To compare clinical features, laboratory data and fetal-maternal outcomes between 1000 women with obstetric APS (OAPS) and 640 with aPL-related obstetric complications not fulfilling Sydney criteria (non-criteria OAPS, NC-OAPS). Methods. This was a retrospective and prospective multicentre study from the European Registry on Obstetric Antiphospholipid Syndrome. Results. A total of 1650 women with 5251 episodes, 3601 of which were historical and 1650 latest episodes, were included. Altogether, 1000 cases (OAPS group) fulfilled the Sydney classification criteria and 650 (NC-OAPS group) did not. Ten NC-OAPS cases were excluded for presenting thrombosis during follow-up. All cases were classified as category I (triple positivity or double positivity for aPL) or category II (simple positivity). Overall, aPL laboratory categories showed significant differences: 29.20% in OAPS vs 17.96% in NC-OAPS (P < 0.0001) for category I, and 70.8% in OAPS vs 82% in NC-OAPS (P < 0.0001) for category II. Significant differences were observed when current obstetric complications were compared (P < 0.001). However, major differences between groups were not observed in treatment rates, livebirths and thrombotic complications. In the NC-OAPS group, 176/640 (27.5%) did not fulfil Sydney clinical criteria (subgroup A), 175/640 (27.34%) had a low titre and/or non-persistent aPL positivity but did meet the clinical criteria (subgroup B) and 289/640 (45.15%) had a high aPL titre but did not fulfil Sydney clinical criteria (subgroup C). Conclusion. Significant clinical and laboratory differences were found between groups. Fetal-maternal outcomes were similar in both groups when treated. These results suggest that we could improve our clinical practice with better understanding of NC-OAPS patients.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1912
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1912
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv RHEUMATOLOGY
ISSN: 14620324
ISSNe: 14620332
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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