The role of oncogene c-MYC in the development and progression of non-alcoholic fatty liver disease in mice
Nonalcoholic fatty liver disease (NAFLD) has rapidly risen as one of the leading etiologies for HCC and represents a large societal and health problem. Many factors are responsible for the high risk of NAFLD and NAFLD-related HCC development. Lately, oncogenes have been suggested to be determinant.T...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/5705 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/5705 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.36(043.2) Liver (diseases) Hígado (enfermedades) Gastroenterología y hepatología 3205.03 Gastroenterología |
| Sumario: | Nonalcoholic fatty liver disease (NAFLD) has rapidly risen as one of the leading etiologies for HCC and represents a large societal and health problem. Many factors are responsible for the high risk of NAFLD and NAFLD-related HCC development. Lately, oncogenes have been suggested to be determinant.The oncogene activation of c-MYC can induce genetic instability, promote the cell cycle, and increase proliferation, thereby accelerating tumor progression, studies also observed a significant c-MYC over expression in livers with CLD including hepatic hepatitis, fibrosis and cirrhosis, and also indicates the overexpression of c-MYC might increase the susceptibility of liver cells to develop HCC; however, their role still remains unknown. Here we overall aimed to analyse the impact of the proto-oncogene c-MYC in the development of murine NAFLD and NAFLD-associated HCC... |
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