The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation

The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft...

Descripción completa

Detalles Bibliográficos
Autores: Noriega, Víctor, Martínez-Laperche, Carolina, Buces, Elena, Pion, Marjorie, Sánchez-Hernández, Noemi, Martín-Antonio, B|||0000-0003-0612-2693, Guillem, Vicent, Bosch-Vizcaya, Anna, Bento, Leyre|||0000-0001-9929-8617, González-Rivera, Milagros, Balsalobre, Pascual, Kwon, Mi|||0000-0002-3855-7774, Serrano Simonneau, David, Gayoso, Jorge, de la Camara, Rafael|||0000-0002-8189-5779, Brunet, Salut|||0000-0003-0491-1672, Rojas-Contreras, Rafael, Nieto, José B., Martínez, Carmen|||0000-0002-8401-7306, González, Marcos, Espigado, Ildefonso|||0000-0002-4043-6613, Vallejo, Juan C., Sampol, Antonia|||0000-0001-7465-6203, Jiménez-Velasco, Antonio|||0000-0001-6421-7872, Urbano Ispizua, Álvaro|||0000-0002-7529-9399, Solano, Carlos|||0000-0003-3702-0817, Gallardo, David|||0000-0003-1615-4592, Díez-Martín, José L., Buño, Ismael|||0000-0003-4931-9170
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:296542
Acceso en línea:https://ddd.uab.cat/record/296542
https://dx.doi.org/urn:doi:10.1371/journal.pone.0140454
Access Level:acceso abierto
Palabra clave:Adult
Aged
Female
Forkhead Transcription Factors
Genetic Association Studies
Genotype
Graft vs Host Disease
Graft vs Leukemia Effect
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic
Survival Analysis
Tissue Donors
Transplantation, Homologous
Young Adult
id ES_3e42c8d9e4d24bde509e9ccbb85f545a
oai_identifier_str oai:ddd.uab.cat:296542
network_acronym_str ES
network_name_str España
repository_id_str
spelling The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantationNoriega, VíctorMartínez-Laperche, CarolinaBuces, ElenaPion, MarjorieSánchez-Hernández, NoemiMartín-Antonio, B|||0000-0003-0612-2693Guillem, VicentBosch-Vizcaya, AnnaBento, Leyre|||0000-0001-9929-8617González-Rivera, MilagrosBalsalobre, PascualKwon, Mi|||0000-0002-3855-7774Serrano Simonneau, DavidGayoso, Jorgede la Camara, Rafael|||0000-0002-8189-5779Brunet, Salut|||0000-0003-0491-1672Rojas-Contreras, RafaelNieto, José B.Martínez, Carmen|||0000-0002-8401-7306González, MarcosEspigado, Ildefonso|||0000-0002-4043-6613Vallejo, Juan C.Sampol, Antonia|||0000-0001-7465-6203Jiménez-Velasco, Antonio|||0000-0001-6421-7872Urbano Ispizua, Álvaro|||0000-0002-7529-9399Solano, Carlos|||0000-0003-3702-0817Gallardo, David|||0000-0003-1615-4592Díez-Martín, José L.Buño, Ismael|||0000-0003-4931-9170AdultAgedFemaleForkhead Transcription FactorsGenetic Association StudiesGenotypeGraft vs Host DiseaseGraft vs Leukemia EffectHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedPolymorphism, GeneticPromoter Regions, GeneticSurvival AnalysisTissue DonorsTransplantation, HomologousYoung AdultThe FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (≤(GT)15) for the (GT) polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto- or alloimmune conditions including type 1 diabetes or graft rejection in renal transplant recipients. However, its impact in the allo-transplant setting has not been analyzed. In the present study, which includes 252 myeloablative HLA-identical allo-transplants, multivariate analysis revealed a lower incidence of grade III-IV acute graft versus host disease (GVHD) in patients transplanted from donors harboring short alleles (OR = 0.26, CI 0.08-0.82, p = 0.021); without affecting chronic GVHD or graft versus leukemia effect, since cumulative incidence of relapse, event free survival and overall survival rates are similar in both groups of patients. Copyright:Universitat Autònoma de Barcelona 22015-01-0120152015-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/296542https://dx.doi.org/urn:doi:10.1371/journal.pone.0140454reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11-00708Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14-01731open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2965422026-06-06T12:50:31Z
dc.title.none.fl_str_mv The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation
title The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation
spellingShingle The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation
Noriega, Víctor
Adult
Aged
Female
Forkhead Transcription Factors
Genetic Association Studies
Genotype
Graft vs Host Disease
Graft vs Leukemia Effect
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic
Survival Analysis
Tissue Donors
Transplantation, Homologous
Young Adult
title_short The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation
title_full The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation
title_fullStr The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation
title_full_unstemmed The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation
title_sort The genotype of the donor for the (GT)n polymorphism in the promoter/enhancer of FOXP3 Is associated with the development of severe acute GVHD but does not affect the GVL effect after myeloablative HLA-Identical allogeneic stem cell transplantation
dc.creator.none.fl_str_mv Noriega, Víctor
Martínez-Laperche, Carolina
Buces, Elena
Pion, Marjorie
Sánchez-Hernández, Noemi
Martín-Antonio, B|||0000-0003-0612-2693
Guillem, Vicent
Bosch-Vizcaya, Anna
Bento, Leyre|||0000-0001-9929-8617
González-Rivera, Milagros
Balsalobre, Pascual
Kwon, Mi|||0000-0002-3855-7774
Serrano Simonneau, David
Gayoso, Jorge
de la Camara, Rafael|||0000-0002-8189-5779
Brunet, Salut|||0000-0003-0491-1672
Rojas-Contreras, Rafael
Nieto, José B.
Martínez, Carmen|||0000-0002-8401-7306
González, Marcos
Espigado, Ildefonso|||0000-0002-4043-6613
Vallejo, Juan C.
Sampol, Antonia|||0000-0001-7465-6203
Jiménez-Velasco, Antonio|||0000-0001-6421-7872
Urbano Ispizua, Álvaro|||0000-0002-7529-9399
Solano, Carlos|||0000-0003-3702-0817
Gallardo, David|||0000-0003-1615-4592
Díez-Martín, José L.
Buño, Ismael|||0000-0003-4931-9170
author Noriega, Víctor
author_facet Noriega, Víctor
Martínez-Laperche, Carolina
Buces, Elena
Pion, Marjorie
Sánchez-Hernández, Noemi
Martín-Antonio, B|||0000-0003-0612-2693
Guillem, Vicent
Bosch-Vizcaya, Anna
Bento, Leyre|||0000-0001-9929-8617
González-Rivera, Milagros
Balsalobre, Pascual
Kwon, Mi|||0000-0002-3855-7774
Serrano Simonneau, David
Gayoso, Jorge
de la Camara, Rafael|||0000-0002-8189-5779
Brunet, Salut|||0000-0003-0491-1672
Rojas-Contreras, Rafael
Nieto, José B.
Martínez, Carmen|||0000-0002-8401-7306
González, Marcos
Espigado, Ildefonso|||0000-0002-4043-6613
Vallejo, Juan C.
Sampol, Antonia|||0000-0001-7465-6203
Jiménez-Velasco, Antonio|||0000-0001-6421-7872
Urbano Ispizua, Álvaro|||0000-0002-7529-9399
Solano, Carlos|||0000-0003-3702-0817
Gallardo, David|||0000-0003-1615-4592
Díez-Martín, José L.
Buño, Ismael|||0000-0003-4931-9170
author_role author
author2 Martínez-Laperche, Carolina
Buces, Elena
Pion, Marjorie
Sánchez-Hernández, Noemi
Martín-Antonio, B|||0000-0003-0612-2693
Guillem, Vicent
Bosch-Vizcaya, Anna
Bento, Leyre|||0000-0001-9929-8617
González-Rivera, Milagros
Balsalobre, Pascual
Kwon, Mi|||0000-0002-3855-7774
Serrano Simonneau, David
Gayoso, Jorge
de la Camara, Rafael|||0000-0002-8189-5779
Brunet, Salut|||0000-0003-0491-1672
Rojas-Contreras, Rafael
Nieto, José B.
Martínez, Carmen|||0000-0002-8401-7306
González, Marcos
Espigado, Ildefonso|||0000-0002-4043-6613
Vallejo, Juan C.
Sampol, Antonia|||0000-0001-7465-6203
Jiménez-Velasco, Antonio|||0000-0001-6421-7872
Urbano Ispizua, Álvaro|||0000-0002-7529-9399
Solano, Carlos|||0000-0003-3702-0817
Gallardo, David|||0000-0003-1615-4592
Díez-Martín, José L.
Buño, Ismael|||0000-0003-4931-9170
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Adult
Aged
Female
Forkhead Transcription Factors
Genetic Association Studies
Genotype
Graft vs Host Disease
Graft vs Leukemia Effect
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic
Survival Analysis
Tissue Donors
Transplantation, Homologous
Young Adult
topic Adult
Aged
Female
Forkhead Transcription Factors
Genetic Association Studies
Genotype
Graft vs Host Disease
Graft vs Leukemia Effect
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic
Survival Analysis
Tissue Donors
Transplantation, Homologous
Young Adult
description The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (≤(GT)15) for the (GT) polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto- or alloimmune conditions including type 1 diabetes or graft rejection in renal transplant recipients. However, its impact in the allo-transplant setting has not been analyzed. In the present study, which includes 252 myeloablative HLA-identical allo-transplants, multivariate analysis revealed a lower incidence of grade III-IV acute graft versus host disease (GVHD) in patients transplanted from donors harboring short alleles (OR = 0.26, CI 0.08-0.82, p = 0.021); without affecting chronic GVHD or graft versus leukemia effect, since cumulative incidence of relapse, event free survival and overall survival rates are similar in both groups of patients. Copyright:
publishDate 2015
dc.date.none.fl_str_mv 2
2015-01-01
2015
2015-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/296542
https://dx.doi.org/urn:doi:10.1371/journal.pone.0140454
url https://ddd.uab.cat/record/296542
https://dx.doi.org/urn:doi:10.1371/journal.pone.0140454
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11-00708
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14-01731
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406521287245824
score 15,81155

Similares en LA Referencia