The effect of omega-3 fatty acids on alcohol-induced damage

Alcohol is the most widely consumed psychoactive substance in the world that has a severe impact on many organs and bodily systems, particularly the liver and nervous system. Alcohol use during pregnancy roots long-lasting changes in the newborns and during adolescence has long-term detrimental effe...

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Authors: Serrano Murgia, Maitane, Rico Barrio, Irantzu, Grandes Moreno, Pedro Rolando
Format: article
Publication Date:2023
Country:España
Institution:Universidad del País Vasco
Repository:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/67662
Online Access:http://hdl.handle.net/10810/67662
Access Level:Open access
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spelling The effect of omega-3 fatty acids on alcohol-induced damageSerrano Murgia, MaitaneRico Barrio, IrantzuGrandes Moreno, Pedro RolandoAlcohol is the most widely consumed psychoactive substance in the world that has a severe impact on many organs and bodily systems, particularly the liver and nervous system. Alcohol use during pregnancy roots long-lasting changes in the newborns and during adolescence has long-term detrimental effects especially on the brain. The brain contains docosahexaenoic acid (DHA), a major omega-3 (n-3) fatty acid (FA) that makes up cell membranes and influences membrane-associated protein function, cell signaling, gene expression and lipid production. N-3 is beneficial in several brain conditions like neurodegenerative diseases, ameliorating cognitive impairment, oxidative stress, neuronal death and inflammation. Because alcohol decreases the levels of n-3, it is timely to know whether n-3 supplementation positively modifies alcohol-induced injuries. The aim of this review is to summarize the state-of-the-art of the n-3 effects on certain conditions caused by alcohol intake, focusing primarily on brain damage and alcoholic liver disease.This work was supported by the Basque Government (IT1620-22); Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III (RD21/0009/0006); Red de Trastornos Adictivos, Instituto de Salud Carlos III, European Regional Development Funds-European Union (ERDF-EU; RD16/0017/0012); and Ministry of Science and Innovation (PID2019-107548RB-I00). MS is in a receipt of a Ph.D. contract from the University of the Basque Country (PIF 19/164).Frontiers Media202420242023info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/67662reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/PID2019-107548RB-I00/https://www.frontiersin.org/articles/10.3389/fnut.2023.1068343/fullinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2023 Serrano, Rico-Barrio and Grandes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Atribución 3.0 Españaoai:addi.ehu.eus:10810/676622026-06-18T09:23:17Z
dc.title.none.fl_str_mv The effect of omega-3 fatty acids on alcohol-induced damage
title The effect of omega-3 fatty acids on alcohol-induced damage
spellingShingle The effect of omega-3 fatty acids on alcohol-induced damage
Serrano Murgia, Maitane
title_short The effect of omega-3 fatty acids on alcohol-induced damage
title_full The effect of omega-3 fatty acids on alcohol-induced damage
title_fullStr The effect of omega-3 fatty acids on alcohol-induced damage
title_full_unstemmed The effect of omega-3 fatty acids on alcohol-induced damage
title_sort The effect of omega-3 fatty acids on alcohol-induced damage
dc.creator.none.fl_str_mv Serrano Murgia, Maitane
Rico Barrio, Irantzu
Grandes Moreno, Pedro Rolando
author Serrano Murgia, Maitane
author_facet Serrano Murgia, Maitane
Rico Barrio, Irantzu
Grandes Moreno, Pedro Rolando
author_role author
author2 Rico Barrio, Irantzu
Grandes Moreno, Pedro Rolando
author2_role author
author
description Alcohol is the most widely consumed psychoactive substance in the world that has a severe impact on many organs and bodily systems, particularly the liver and nervous system. Alcohol use during pregnancy roots long-lasting changes in the newborns and during adolescence has long-term detrimental effects especially on the brain. The brain contains docosahexaenoic acid (DHA), a major omega-3 (n-3) fatty acid (FA) that makes up cell membranes and influences membrane-associated protein function, cell signaling, gene expression and lipid production. N-3 is beneficial in several brain conditions like neurodegenerative diseases, ameliorating cognitive impairment, oxidative stress, neuronal death and inflammation. Because alcohol decreases the levels of n-3, it is timely to know whether n-3 supplementation positively modifies alcohol-induced injuries. The aim of this review is to summarize the state-of-the-art of the n-3 effects on certain conditions caused by alcohol intake, focusing primarily on brain damage and alcoholic liver disease.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/67662
url http://hdl.handle.net/10810/67662
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/PID2019-107548RB-I00/
https://www.frontiersin.org/articles/10.3389/fnut.2023.1068343/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
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