Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics

Accurate dietary assessment is a challenge in nutritional research, needing powerful and robust tools for reliable measurement of food intake biomarkers. In this work, we have developed a novel quantitative dietary fingerprinting (QDF) approach, which enables for the first time the simultaneous quan...

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Autores: González-Domínguez, Raúl, Urpí Sardà, Mireia, Jáuregui Pallarés, Olga, Needs, Paul W., Kroon, Paul A., Andrés Lacueva, Ma. Cristina
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/157980
Acceso en línea:https://hdl.handle.net/2445/157980
Access Level:acceso abierto
Palabra clave:Metabolòmica
Suplements nutritius
Cromatografia de líquids
Metabolomics
Dietary supplements
Liquid chromatography
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spelling Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary NutrimetabolomicsGonzález-Domínguez, RaúlUrpí Sardà, MireiaJáuregui Pallarés, OlgaNeeds, Paul W.Kroon, Paul A.Andrés Lacueva, Ma. CristinaMetabolòmicaSuplements nutritiusCromatografia de líquidsMetabolomicsDietary supplementsLiquid chromatographyAccurate dietary assessment is a challenge in nutritional research, needing powerful and robust tools for reliable measurement of food intake biomarkers. In this work, we have developed a novel quantitative dietary fingerprinting (QDF) approach, which enables for the first time the simultaneous quantitation of about 350 urinary food-derived metabolites, including (poly)phenolic aglycones, phase II metabolites, and microbial-transformed compounds, as well as other compounds (e.g., glucosinolates, amino acid derivatives, methylxanthines, alkaloids, and markers of alcohol and tobacco consumption). This method was fully validated for 220 metabolites, yielding good linearity, high sensitivity and precision, accurate recovery rates, and negligible matrix effects. Furthermore, 127 additional phase II metabolites were also included in this method after identification in urines collected from acute dietary interventions with various foods. Thus, this metabolomic approach represents one-step further toward precision nutrition and the objective of improving the accurateness and comprehensiveness in the assessment of dietary patterns and lifestyles.American Chemical Society2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/157980Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.8b07023Journal of Agricultural and Food Chemistry, 2019, vol. 68, num. 7, p. 1851-1861https://doi.org/10.1021/acs.jafc.8b07023(c) American Chemical Society , 2019info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1579802026-05-27T06:46:51Z
dc.title.none.fl_str_mv Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics
title Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics
spellingShingle Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics
González-Domínguez, Raúl
Metabolòmica
Suplements nutritius
Cromatografia de líquids
Metabolomics
Dietary supplements
Liquid chromatography
title_short Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics
title_full Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics
title_fullStr Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics
title_full_unstemmed Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics
title_sort Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics
dc.creator.none.fl_str_mv González-Domínguez, Raúl
Urpí Sardà, Mireia
Jáuregui Pallarés, Olga
Needs, Paul W.
Kroon, Paul A.
Andrés Lacueva, Ma. Cristina
author González-Domínguez, Raúl
author_facet González-Domínguez, Raúl
Urpí Sardà, Mireia
Jáuregui Pallarés, Olga
Needs, Paul W.
Kroon, Paul A.
Andrés Lacueva, Ma. Cristina
author_role author
author2 Urpí Sardà, Mireia
Jáuregui Pallarés, Olga
Needs, Paul W.
Kroon, Paul A.
Andrés Lacueva, Ma. Cristina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Metabolòmica
Suplements nutritius
Cromatografia de líquids
Metabolomics
Dietary supplements
Liquid chromatography
topic Metabolòmica
Suplements nutritius
Cromatografia de líquids
Metabolomics
Dietary supplements
Liquid chromatography
description Accurate dietary assessment is a challenge in nutritional research, needing powerful and robust tools for reliable measurement of food intake biomarkers. In this work, we have developed a novel quantitative dietary fingerprinting (QDF) approach, which enables for the first time the simultaneous quantitation of about 350 urinary food-derived metabolites, including (poly)phenolic aglycones, phase II metabolites, and microbial-transformed compounds, as well as other compounds (e.g., glucosinolates, amino acid derivatives, methylxanthines, alkaloids, and markers of alcohol and tobacco consumption). This method was fully validated for 220 metabolites, yielding good linearity, high sensitivity and precision, accurate recovery rates, and negligible matrix effects. Furthermore, 127 additional phase II metabolites were also included in this method after identification in urines collected from acute dietary interventions with various foods. Thus, this metabolomic approach represents one-step further toward precision nutrition and the objective of improving the accurateness and comprehensiveness in the assessment of dietary patterns and lifestyles.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/157980
url https://hdl.handle.net/2445/157980
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.8b07023
Journal of Agricultural and Food Chemistry, 2019, vol. 68, num. 7, p. 1851-1861
https://doi.org/10.1021/acs.jafc.8b07023
dc.rights.none.fl_str_mv (c) American Chemical Society , 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Chemical Society , 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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