Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model

Expression of the nucleolar chaperones nucleolin (NCL) and nucleophosmin (NPM1), upstream binding transcription factor (UBTF), rRNA18S, rRNA28S, and several genes encoding ribosomal proteins (RPs) is decreased in frontal cortex area 8 at advanced stages of Alzheimer's disease (AD). This is acco...

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Autores: Garcia Esparcia, Paula, Sideris-Lampretsas, Georgios, Hernández Ortega, Karina, Grau-Rivera, Oriol, Sklaviadis, Theodoros, Gelpi, Ellen, Ferrer, Isidro (Ferrer Abizanda)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/143678
Acceso en línea:https://hdl.handle.net/2445/143678
Access Level:acceso abierto
Palabra clave:Ratolins transgènics
Malaltia d'Alzheimer
Síntesi proteica
RNA
Transgenic mice
Alzheimer's disease
Protein synthesis
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spelling Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse modelGarcia Esparcia, PaulaSideris-Lampretsas, GeorgiosHernández Ortega, KarinaGrau-Rivera, OriolSklaviadis, TheodorosGelpi, EllenFerrer, Isidro (Ferrer Abizanda)Ratolins transgènicsMalaltia d'AlzheimerSíntesi proteicaRNATransgenic miceAlzheimer's diseaseProtein synthesisRNAExpression of the nucleolar chaperones nucleolin (NCL) and nucleophosmin (NPM1), upstream binding transcription factor (UBTF), rRNA18S, rRNA28S, and several genes encoding ribosomal proteins (RPs) is decreased in frontal cortex area 8 at advanced stages of Alzheimer's disease (AD). This is accompanied by reduced protein levels of elongation factors eEF1A and eEF2. Changes are more marked in AD cases with rapid course (rpAD), as initiation factor eIF3η is significantly down-regulated and several RP genes up-regulated in rpAD when compared with typical AD. These changes contrast with those seen in APP/PS1 transgenic mice used as a model of AD-like β-amyloidopathy; Ncl mRNA, rRNA18S, rRNA28S and seven out of fifteen assessed RP genes are up-regulated in APP/PS1 mice aged 20 months; only eEF2 protein levels are reduced in transgenic mice. Our findings show marked altered expression of molecules linked to the protein synthesis machinery from the nucleolus to the ribosome in frontal cortex at terminal stages of AD which differs from that seen in APP/PS1 transgenic mice, thus further suggesting that molecular signals in mouse models do not apply to real human disease counterparts.e-Century Publishing2019201920172019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/143678Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://www.ajnd.us/V6_N2.htmlAmerican Journal Neurodegenerative Diseases , 2017, vol. 6, num. 2, p. 15-25cc-by-nc-nd (c) e-Century Publishing, 2017http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1436782026-05-29T05:05:01Z
dc.title.none.fl_str_mv Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
title Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
spellingShingle Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
Garcia Esparcia, Paula
Ratolins transgènics
Malaltia d'Alzheimer
Síntesi proteica
RNA
Transgenic mice
Alzheimer's disease
Protein synthesis
RNA
title_short Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
title_full Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
title_fullStr Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
title_full_unstemmed Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
title_sort Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model
dc.creator.none.fl_str_mv Garcia Esparcia, Paula
Sideris-Lampretsas, Georgios
Hernández Ortega, Karina
Grau-Rivera, Oriol
Sklaviadis, Theodoros
Gelpi, Ellen
Ferrer, Isidro (Ferrer Abizanda)
author Garcia Esparcia, Paula
author_facet Garcia Esparcia, Paula
Sideris-Lampretsas, Georgios
Hernández Ortega, Karina
Grau-Rivera, Oriol
Sklaviadis, Theodoros
Gelpi, Ellen
Ferrer, Isidro (Ferrer Abizanda)
author_role author
author2 Sideris-Lampretsas, Georgios
Hernández Ortega, Karina
Grau-Rivera, Oriol
Sklaviadis, Theodoros
Gelpi, Ellen
Ferrer, Isidro (Ferrer Abizanda)
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ratolins transgènics
Malaltia d'Alzheimer
Síntesi proteica
RNA
Transgenic mice
Alzheimer's disease
Protein synthesis
RNA
topic Ratolins transgènics
Malaltia d'Alzheimer
Síntesi proteica
RNA
Transgenic mice
Alzheimer's disease
Protein synthesis
RNA
description Expression of the nucleolar chaperones nucleolin (NCL) and nucleophosmin (NPM1), upstream binding transcription factor (UBTF), rRNA18S, rRNA28S, and several genes encoding ribosomal proteins (RPs) is decreased in frontal cortex area 8 at advanced stages of Alzheimer's disease (AD). This is accompanied by reduced protein levels of elongation factors eEF1A and eEF2. Changes are more marked in AD cases with rapid course (rpAD), as initiation factor eIF3η is significantly down-regulated and several RP genes up-regulated in rpAD when compared with typical AD. These changes contrast with those seen in APP/PS1 transgenic mice used as a model of AD-like β-amyloidopathy; Ncl mRNA, rRNA18S, rRNA28S and seven out of fifteen assessed RP genes are up-regulated in APP/PS1 mice aged 20 months; only eEF2 protein levels are reduced in transgenic mice. Our findings show marked altered expression of molecules linked to the protein synthesis machinery from the nucleolus to the ribosome in frontal cortex at terminal stages of AD which differs from that seen in APP/PS1 transgenic mice, thus further suggesting that molecular signals in mouse models do not apply to real human disease counterparts.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/143678
url https://hdl.handle.net/2445/143678
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://www.ajnd.us/V6_N2.html
American Journal Neurodegenerative Diseases , 2017, vol. 6, num. 2, p. 15-25
dc.rights.none.fl_str_mv cc-by-nc-nd (c) e-Century Publishing, 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) e-Century Publishing, 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv e-Century Publishing
publisher.none.fl_str_mv e-Century Publishing
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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