Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study
The purpose of this trial was to study feasibility and tolerance of a dose-intensive multicyclic alternating induction chemotherapy with repeated stem cell support in a series of 43 metastatic breast cancer patients. Anthracycline-naive patients (n = 21) received cyclophosphamide 2.5 g/m2 plus doxor...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2001 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/22736 |
| Acceso en línea: | https://hdl.handle.net/10171/22736 |
| Access Level: | acceso abierto |
| Palabra clave: | Dose-intensity Breast cancer Peripheral blood stem cells |
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Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility studyGarcia-Rayo, S. (S.)|||/items/5872c5cf-c545-4aaa-9448-d3d626e399dbPerez-Calvo, J. (Javier)|||/items/638f8bcc-03df-440c-9aec-62a991b95b24Martin-Algarra, S. (Salvador)|||/items/2fba8e8b-e087-4ab0-82e3-a4d157f1e0ccMartinez-Monge, R. (Rafael)|||/items/4f936ddc-91ab-4824-b659-c6c6dab6698bFernandez-Hidalgo, Ó. (Óscar)|||/items/81d33bbe-62df-4d48-aeb0-d07f3b1b16a6Subira, L. (L.)|||/items/24b38dc2-d9af-4635-94d3-6a80723db262Martinez-Aguillo, M. (M.)|||/items/1a956353-bfc8-4100-896e-781680752477Rebollo, J. (J.)|||/items/cb3e037c-8404-4b0f-9ca1-d807fbd5c02cAzinovic, I. (Ignacio)|||/items/44d8f3ec-afbe-47c7-962b-fb1ddb5da68eBrugarolas, A. (A.)|||/items/172258ec-bf10-4b35-a5e8-9ad2953a8559Dose-intensityBreast cancerPeripheral blood stem cellsThe purpose of this trial was to study feasibility and tolerance of a dose-intensive multicyclic alternating induction chemotherapy with repeated stem cell support in a series of 43 metastatic breast cancer patients. Anthracycline-naive patients (n = 21) received cyclophosphamide 2.5 g/m2 plus doxorubicin 80 mg/m2 alternating every 14 days with paclitaxel 200-350 mg/m2 plus cisplatin 120 mg/m2. Patients who had previously received anthracyclines (n = 22) received cisplatin 120 mg/m2 plus etoposide 600 mg/m2 alternating with paclitaxel 200-350 mg/m2 plus ifosfamide 8 g/m2. Peripheral blood stem cells were infused after every course except the first, with a median CD34+ dose of 2.1 ´ 106/kg per cycle. Positive selection of CD34+ cells was performed in good mobilizers. The median number of cycles administered was six (4-8), and the time interval between them was 17 days. Median summation dose intensities (SDI) actually administered for the CA-TP and PE-TI protocol were 4.95 and 4.69, respectively (87% of scheduled SDI). There were 15 complete (35%) and 21 partial responses (49%), for an overall response rate of 84% (95% CI, 73%-95%). Infection or neutropenic fever occurred in 50% of the cycles. There was one treatment-related death. After a median follow-up of 26 months, the median event-free-survival was 12 months (95% CI: 10-14) and overall survival was 31 months. These high dose-intensity induction treatments seem to be feasible with sequential stem cell support.NatureDadun. Depósito Académico Digital Universidad de Navarra20122012-06-2920012001-01-0120012001-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/22736reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/227362026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study |
| title |
Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study |
| spellingShingle |
Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study Garcia-Rayo, S. (S.)|||/items/5872c5cf-c545-4aaa-9448-d3d626e399db Dose-intensity Breast cancer Peripheral blood stem cells |
| title_short |
Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study |
| title_full |
Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study |
| title_fullStr |
Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study |
| title_full_unstemmed |
Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study |
| title_sort |
Multiple cycles of dose-intensive chemotherapy with repeated stem cell support as induction treatment in metastatic breast cancer: a feasibility study |
| dc.creator.none.fl_str_mv |
Garcia-Rayo, S. (S.)|||/items/5872c5cf-c545-4aaa-9448-d3d626e399db Perez-Calvo, J. (Javier)|||/items/638f8bcc-03df-440c-9aec-62a991b95b24 Martin-Algarra, S. (Salvador)|||/items/2fba8e8b-e087-4ab0-82e3-a4d157f1e0cc Martinez-Monge, R. (Rafael)|||/items/4f936ddc-91ab-4824-b659-c6c6dab6698b Fernandez-Hidalgo, Ó. (Óscar)|||/items/81d33bbe-62df-4d48-aeb0-d07f3b1b16a6 Subira, L. (L.)|||/items/24b38dc2-d9af-4635-94d3-6a80723db262 Martinez-Aguillo, M. (M.)|||/items/1a956353-bfc8-4100-896e-781680752477 Rebollo, J. (J.)|||/items/cb3e037c-8404-4b0f-9ca1-d807fbd5c02c Azinovic, I. (Ignacio)|||/items/44d8f3ec-afbe-47c7-962b-fb1ddb5da68e Brugarolas, A. (A.)|||/items/172258ec-bf10-4b35-a5e8-9ad2953a8559 |
| author |
Garcia-Rayo, S. (S.)|||/items/5872c5cf-c545-4aaa-9448-d3d626e399db |
| author_facet |
Garcia-Rayo, S. (S.)|||/items/5872c5cf-c545-4aaa-9448-d3d626e399db Perez-Calvo, J. (Javier)|||/items/638f8bcc-03df-440c-9aec-62a991b95b24 Martin-Algarra, S. (Salvador)|||/items/2fba8e8b-e087-4ab0-82e3-a4d157f1e0cc Martinez-Monge, R. (Rafael)|||/items/4f936ddc-91ab-4824-b659-c6c6dab6698b Fernandez-Hidalgo, Ó. (Óscar)|||/items/81d33bbe-62df-4d48-aeb0-d07f3b1b16a6 Subira, L. (L.)|||/items/24b38dc2-d9af-4635-94d3-6a80723db262 Martinez-Aguillo, M. (M.)|||/items/1a956353-bfc8-4100-896e-781680752477 Rebollo, J. (J.)|||/items/cb3e037c-8404-4b0f-9ca1-d807fbd5c02c Azinovic, I. (Ignacio)|||/items/44d8f3ec-afbe-47c7-962b-fb1ddb5da68e Brugarolas, A. (A.)|||/items/172258ec-bf10-4b35-a5e8-9ad2953a8559 |
| author_role |
author |
| author2 |
Perez-Calvo, J. (Javier)|||/items/638f8bcc-03df-440c-9aec-62a991b95b24 Martin-Algarra, S. (Salvador)|||/items/2fba8e8b-e087-4ab0-82e3-a4d157f1e0cc Martinez-Monge, R. (Rafael)|||/items/4f936ddc-91ab-4824-b659-c6c6dab6698b Fernandez-Hidalgo, Ó. (Óscar)|||/items/81d33bbe-62df-4d48-aeb0-d07f3b1b16a6 Subira, L. (L.)|||/items/24b38dc2-d9af-4635-94d3-6a80723db262 Martinez-Aguillo, M. (M.)|||/items/1a956353-bfc8-4100-896e-781680752477 Rebollo, J. (J.)|||/items/cb3e037c-8404-4b0f-9ca1-d807fbd5c02c Azinovic, I. (Ignacio)|||/items/44d8f3ec-afbe-47c7-962b-fb1ddb5da68e Brugarolas, A. (A.)|||/items/172258ec-bf10-4b35-a5e8-9ad2953a8559 |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Dose-intensity Breast cancer Peripheral blood stem cells |
| topic |
Dose-intensity Breast cancer Peripheral blood stem cells |
| description |
The purpose of this trial was to study feasibility and tolerance of a dose-intensive multicyclic alternating induction chemotherapy with repeated stem cell support in a series of 43 metastatic breast cancer patients. Anthracycline-naive patients (n = 21) received cyclophosphamide 2.5 g/m2 plus doxorubicin 80 mg/m2 alternating every 14 days with paclitaxel 200-350 mg/m2 plus cisplatin 120 mg/m2. Patients who had previously received anthracyclines (n = 22) received cisplatin 120 mg/m2 plus etoposide 600 mg/m2 alternating with paclitaxel 200-350 mg/m2 plus ifosfamide 8 g/m2. Peripheral blood stem cells were infused after every course except the first, with a median CD34+ dose of 2.1 ´ 106/kg per cycle. Positive selection of CD34+ cells was performed in good mobilizers. The median number of cycles administered was six (4-8), and the time interval between them was 17 days. Median summation dose intensities (SDI) actually administered for the CA-TP and PE-TI protocol were 4.95 and 4.69, respectively (87% of scheduled SDI). There were 15 complete (35%) and 21 partial responses (49%), for an overall response rate of 84% (95% CI, 73%-95%). Infection or neutropenic fever occurred in 50% of the cycles. There was one treatment-related death. After a median follow-up of 26 months, the median event-free-survival was 12 months (95% CI: 10-14) and overall survival was 31 months. These high dose-intensity induction treatments seem to be feasible with sequential stem cell support. |
| publishDate |
2001 |
| dc.date.none.fl_str_mv |
2001 2001-01-01 2001 2001-01-01 2012 2012-06-29 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/22736 |
| url |
https://hdl.handle.net/10171/22736 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Nature |
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Nature |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869406504013004800 |
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15,301603 |