Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity

Context: MicroRNAs (miRNAs) are valuable circulating biomarkers and therapeutic targets for metabolic diseases. Objective: The objective of the study was to define the pattern of circulating miRNAs in pregestational and gestational obesity and to explore their associations with maternal metabolic pa...

Descripción completa

Detalles Bibliográficos
Autores: Carreras-Badosa G, Bonmatí A, Ortega FJ, Mercader JM, Guindo-Martínez M, Torrents D, Prats-Puig A, Martinez-Calcerrada JM, Platero E, De Zegher F, Ibáñez L, Fernandez-Real JM, Lopez-Bermejo A, Bassols J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p8353
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8353
Access Level:acceso abierto
id ES_3e09b771f0d38c2b2cb857e16092e4ad
oai_identifier_str oai:fsjd.fundanetsuite.com:p8353
network_acronym_str ES
network_name_str España
repository_id_str
spelling Altered Circulating miRNA Expression Profile in Pregestational and Gestational ObesityCarreras-Badosa GBonmatí AOrtega FJMercader JMGuindo-Martínez MTorrents DPrats-Puig AMartinez-Calcerrada JMPlatero EDe Zegher FIbáñez LFernandez-Real JMLopez-Bermejo ABassols JContext: MicroRNAs (miRNAs) are valuable circulating biomarkers and therapeutic targets for metabolic diseases. Objective: The objective of the study was to define the pattern of circulating miRNAs in pregestational and gestational obesity and to explore their associations with maternal metabolic parameters and with markers for pre- and postnatal growth. Design, Settings, and Main Outcome Measure: TaqMan low-density arrays were used to profile plasma miRNAs in six women with pregestational obesity (PregestOB), six with gestational obesity (GestOB), and six with normal pregnancies (control) during the second trimester of gestation. The most relevant miRNAs were validated in 70 pregnant women (20 PregestOB, 25 GestOB, and 25 control). Maternal metabolic parameters including glucose, glycated hemoglobin, homeostasis model assessment index of insulin resistance, C-peptide, and lipids were assessed. Placentas were weighed at delivery and newborns also during 6 months of life. Results: We identified 13 circulating miRNAs differentially expressed in maternal obesity, including decreased levels of miR-29c, miR-99b, miR-103, miR-221, and miR-340 and increased levels of miR-30a-5p, miR-130a, and miR-150 in GestOB; and decreased levels of miR-122, miR-324-3p, miR-375, and miR-652 and increased levels of miR-625 in both PregestOB and GestOB (P < .05 to P < .0001 vs control). Decreased levels of several of these miRNAs associated with a more adverse maternal metabolic status (more pregnancy weight gain, glucose, glycated hemoglobin, homeostasis model assessment index of insulin resistance, C-peptide, and triacylglycerol and less high density lipoprotein cholesterol), with more placental weight, weight at birth, and weight at 6 months of life (all P < .05 to P < .001). Conclusions: This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth.ENDOCRINE SOC2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8353JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISMISSN: 0021972XISSNe: 19457197reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p83532026-05-27T12:37:41Z
dc.title.none.fl_str_mv Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
title Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
spellingShingle Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
Carreras-Badosa G
title_short Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
title_full Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
title_fullStr Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
title_full_unstemmed Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
title_sort Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
dc.creator.none.fl_str_mv Carreras-Badosa G
Bonmatí A
Ortega FJ
Mercader JM
Guindo-Martínez M
Torrents D
Prats-Puig A
Martinez-Calcerrada JM
Platero E
De Zegher F
Ibáñez L
Fernandez-Real JM
Lopez-Bermejo A
Bassols J
author Carreras-Badosa G
author_facet Carreras-Badosa G
Bonmatí A
Ortega FJ
Mercader JM
Guindo-Martínez M
Torrents D
Prats-Puig A
Martinez-Calcerrada JM
Platero E
De Zegher F
Ibáñez L
Fernandez-Real JM
Lopez-Bermejo A
Bassols J
author_role author
author2 Bonmatí A
Ortega FJ
Mercader JM
Guindo-Martínez M
Torrents D
Prats-Puig A
Martinez-Calcerrada JM
Platero E
De Zegher F
Ibáñez L
Fernandez-Real JM
Lopez-Bermejo A
Bassols J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
description Context: MicroRNAs (miRNAs) are valuable circulating biomarkers and therapeutic targets for metabolic diseases. Objective: The objective of the study was to define the pattern of circulating miRNAs in pregestational and gestational obesity and to explore their associations with maternal metabolic parameters and with markers for pre- and postnatal growth. Design, Settings, and Main Outcome Measure: TaqMan low-density arrays were used to profile plasma miRNAs in six women with pregestational obesity (PregestOB), six with gestational obesity (GestOB), and six with normal pregnancies (control) during the second trimester of gestation. The most relevant miRNAs were validated in 70 pregnant women (20 PregestOB, 25 GestOB, and 25 control). Maternal metabolic parameters including glucose, glycated hemoglobin, homeostasis model assessment index of insulin resistance, C-peptide, and lipids were assessed. Placentas were weighed at delivery and newborns also during 6 months of life. Results: We identified 13 circulating miRNAs differentially expressed in maternal obesity, including decreased levels of miR-29c, miR-99b, miR-103, miR-221, and miR-340 and increased levels of miR-30a-5p, miR-130a, and miR-150 in GestOB; and decreased levels of miR-122, miR-324-3p, miR-375, and miR-652 and increased levels of miR-625 in both PregestOB and GestOB (P < .05 to P < .0001 vs control). Decreased levels of several of these miRNAs associated with a more adverse maternal metabolic status (more pregnancy weight gain, glucose, glycated hemoglobin, homeostasis model assessment index of insulin resistance, C-peptide, and triacylglycerol and less high density lipoprotein cholesterol), with more placental weight, weight at birth, and weight at 6 months of life (all P < .05 to P < .001). Conclusions: This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8353
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8353
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ENDOCRINE SOC
publisher.none.fl_str_mv ENDOCRINE SOC
dc.source.none.fl_str_mv JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
ISSN: 0021972X
ISSNe: 19457197
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406493175971840
score 15,812429

Similares en LA Referencia