Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods

Digits develop in the distal part of the embryonic limb primordium as radial prechondrogenic condensations separated by undifferentiated mesoderm. In a short time interval the interdigital mesoderm undergoes massive degeneration to determine the formation of free digits. This fascinating process has...

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Autores: Montero Simón, Juan Antonio|||0000-0001-9099-5344, Lorda Díez, Carlos Ignacio|||0000-0002-3248-9918, Hurlé González, Juan M.|||0000-0002-4685-025X
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/20730
Acceso en línea:http://hdl.handle.net/10902/20730
Access Level:acceso abierto
Palabra clave:Apoptosis
Cell Death Genes
Developmental Senescence
Extrinsic Pathway
Lysosomes
Mitochondrial Pathway
Programmed Cell Death
Tendon Differentiation
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spelling Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic TetrapodsMontero Simón, Juan Antonio|||0000-0001-9099-5344Lorda Díez, Carlos Ignacio|||0000-0002-3248-9918Hurlé González, Juan M.|||0000-0002-4685-025XApoptosisCell Death GenesDevelopmental SenescenceExtrinsic PathwayLysosomesMitochondrial PathwayProgrammed Cell DeathTendon DifferentiationDigits develop in the distal part of the embryonic limb primordium as radial prechondrogenic condensations separated by undifferentiated mesoderm. In a short time interval the interdigital mesoderm undergoes massive degeneration to determine the formation of free digits. This fascinating process has often been considered as an altruistic cell suicide that is evolutionarily-regulated in species with different degrees of digit webbing. Initial descriptions of interdigit remodeling considered lysosomes as the primary cause of the degenerative process. However, the functional significance of lysosomes lost interest among researcher and was displaced to a secondary role because the introduction of the term apoptosis. Accumulating evidence in recent decades has revealed that, far from being a unique method of embryonic cell death, apoptosis is only one among several redundant dying mechanisms accounting for the elimination of tissues during embryonic development. Developmental cell senescence has emerged in the last decade as a primary factor implicated in interdigit remodeling. Our review proposes that cell senescence is the biological process identified by vital staining in embryonic models and implicates lysosomes in programmed cell death. We review major structural changes associated with interdigit remodeling that may be driven by cell senescence. Furthermore, the identification of cell senescence lacking tissue degeneration, associated with the maturation of the digit tendons at the same stages of interdigital remodeling, allowed us to distinguish between two functionally distinct types of embryonic cell senescence, "constructive" and "destructive."This work was supported by a grant (BFU2017-84046-P) from the Spanish Science and Innovation Ministry to JM.FrontiersUniversidad de Cantabria20202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/20730Front Cell Dev Biol . 2020 Oct 23;8:593761reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/207302026-06-02T12:39:31Z
dc.title.none.fl_str_mv Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
title Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
spellingShingle Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
Montero Simón, Juan Antonio|||0000-0001-9099-5344
Apoptosis
Cell Death Genes
Developmental Senescence
Extrinsic Pathway
Lysosomes
Mitochondrial Pathway
Programmed Cell Death
Tendon Differentiation
title_short Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
title_full Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
title_fullStr Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
title_full_unstemmed Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
title_sort Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
dc.creator.none.fl_str_mv Montero Simón, Juan Antonio|||0000-0001-9099-5344
Lorda Díez, Carlos Ignacio|||0000-0002-3248-9918
Hurlé González, Juan M.|||0000-0002-4685-025X
author Montero Simón, Juan Antonio|||0000-0001-9099-5344
author_facet Montero Simón, Juan Antonio|||0000-0001-9099-5344
Lorda Díez, Carlos Ignacio|||0000-0002-3248-9918
Hurlé González, Juan M.|||0000-0002-4685-025X
author_role author
author2 Lorda Díez, Carlos Ignacio|||0000-0002-3248-9918
Hurlé González, Juan M.|||0000-0002-4685-025X
author2_role author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Apoptosis
Cell Death Genes
Developmental Senescence
Extrinsic Pathway
Lysosomes
Mitochondrial Pathway
Programmed Cell Death
Tendon Differentiation
topic Apoptosis
Cell Death Genes
Developmental Senescence
Extrinsic Pathway
Lysosomes
Mitochondrial Pathway
Programmed Cell Death
Tendon Differentiation
description Digits develop in the distal part of the embryonic limb primordium as radial prechondrogenic condensations separated by undifferentiated mesoderm. In a short time interval the interdigital mesoderm undergoes massive degeneration to determine the formation of free digits. This fascinating process has often been considered as an altruistic cell suicide that is evolutionarily-regulated in species with different degrees of digit webbing. Initial descriptions of interdigit remodeling considered lysosomes as the primary cause of the degenerative process. However, the functional significance of lysosomes lost interest among researcher and was displaced to a secondary role because the introduction of the term apoptosis. Accumulating evidence in recent decades has revealed that, far from being a unique method of embryonic cell death, apoptosis is only one among several redundant dying mechanisms accounting for the elimination of tissues during embryonic development. Developmental cell senescence has emerged in the last decade as a primary factor implicated in interdigit remodeling. Our review proposes that cell senescence is the biological process identified by vital staining in embryonic models and implicates lysosomes in programmed cell death. We review major structural changes associated with interdigit remodeling that may be driven by cell senescence. Furthermore, the identification of cell senescence lacking tissue degeneration, associated with the maturation of the digit tendons at the same stages of interdigital remodeling, allowed us to distinguish between two functionally distinct types of embryonic cell senescence, "constructive" and "destructive."
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/20730
url http://hdl.handle.net/10902/20730
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv Front Cell Dev Biol . 2020 Oct 23;8:593761
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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