Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study
Background/Objectives: Preclinical studies have evidenced a peripheral nerve blockade with kilohertz high-frequency alternating current (KHFAC) stimulation. It could have a potential effect on aberrant nerve hyperactivity, such as tremor in people with Parkinson’s disease (PwPD). The objective was t...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/375469 |
| Acceso en línea: | http://hdl.handle.net/10261/375469 |
| Access Level: | acceso abierto |
| Palabra clave: | Parkinson’s disease High-frequency alternating current Tremor Transcutaneous electrical stimulation Handgrip strength Nerve block Randomized controlled trial |
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Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover StudyFernández-Pérez, Juan J.Avendaño-Coy, J.Serrano Muñoz, DiegoOliveira Barroso, F.Montero-Pardo, CristinaLópez-Moreno, BeatrizLerín-Calvo, AlfredoRomero Muñoz, Juan P.Gómez Soriano, JulioParkinson’s diseaseHigh-frequency alternating currentTremorTranscutaneous electrical stimulationHandgrip strengthNerve blockRandomized controlled trialBackground/Objectives: Preclinical studies have evidenced a peripheral nerve blockade with kilohertz high-frequency alternating current (KHFAC) stimulation. It could have a potential effect on aberrant nerve hyperactivity, such as tremor in people with Parkinson’s disease (PwPD). The objective was to investigate the effects of transcutaneous KHFAC at 10 kHz compared with sham intervention on tremor modulation, upper limb motor function, and adverse events in PwPD. Methods: This randomized, double-blind, crossover trial included PwPD, who received transcutaneous KHFAC and sham interventions, within a 48 h washout period. Measurements were taken pre-intervention, during, immediately after, and 10 min post-intervention. The main outcomes were rest, postural, and kinetic tremor acceleration. Secondary outcomes were handgrip strength, nine-hole peg test (NHPT), movement onset time, and adverse events. Results: Sixteen PwPD were analyzed. Kinetic tremor diminished only in active treatment from baseline at post-intervention (−32.3% (SD 63.3); p = 0.03) and 10 min after intervention (−38.9% (SD 60.3); p = 0.03). Active treatment showed a greater reduction in kinetic tremor at post-treatment compared to sham (−58.7% SD 123; p = 0.055) close to reaching statistical significance. Only active intervention diminished movement onset time at post-intervention (−26.9% (SD 28.3); p = 0.04). Active intervention diminished handgrip strength compared to sham intervention during the stimulation (−6.6% (SD 10.0); p = 0.02). No relevant adverse effects were reported. Conclusions: KHFAC stimulation at 10 kHz appeared safe and showed potential benefits for reducing kinetic tremor in PwPD. The transient reduction in grip strength suggested an effect on alpha-motoneurons. However, further studies with larger sample sizes are necessary to confirm these findings.This study was funded by the Spanish Ministry of Science and Innovation, Spanish government MCIN/AEI/10.13039/501100011033, grant number PID2020-119752RA-I00.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520242025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/375469reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119752RA-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/jcm13247566Avendaño Coy, J.; Fernández Pérez, J. J.; Serrano Muñoz, D.; Gomez Soriano, J.; 2024; Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson's Disease: A double-blind, randomized, crossover study [Dataset]; Zenodo; v.1; https://doi.org/10.5281/zenodo.14093286https://doi.org/10.3390/jcm13247566Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3754692026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study |
| title |
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study |
| spellingShingle |
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study Fernández-Pérez, Juan J. Parkinson’s disease High-frequency alternating current Tremor Transcutaneous electrical stimulation Handgrip strength Nerve block Randomized controlled trial |
| title_short |
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study |
| title_full |
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study |
| title_fullStr |
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study |
| title_full_unstemmed |
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study |
| title_sort |
Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson’s Disease: A Double-Blind, Randomized, Crossover Study |
| dc.creator.none.fl_str_mv |
Fernández-Pérez, Juan J. Avendaño-Coy, J. Serrano Muñoz, Diego Oliveira Barroso, F. Montero-Pardo, Cristina López-Moreno, Beatriz Lerín-Calvo, Alfredo Romero Muñoz, Juan P. Gómez Soriano, Julio |
| author |
Fernández-Pérez, Juan J. |
| author_facet |
Fernández-Pérez, Juan J. Avendaño-Coy, J. Serrano Muñoz, Diego Oliveira Barroso, F. Montero-Pardo, Cristina López-Moreno, Beatriz Lerín-Calvo, Alfredo Romero Muñoz, Juan P. Gómez Soriano, Julio |
| author_role |
author |
| author2 |
Avendaño-Coy, J. Serrano Muñoz, Diego Oliveira Barroso, F. Montero-Pardo, Cristina López-Moreno, Beatriz Lerín-Calvo, Alfredo Romero Muñoz, Juan P. Gómez Soriano, Julio |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Ciencia e Innovación (España) Agencia Estatal de Investigación (España) Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Parkinson’s disease High-frequency alternating current Tremor Transcutaneous electrical stimulation Handgrip strength Nerve block Randomized controlled trial |
| topic |
Parkinson’s disease High-frequency alternating current Tremor Transcutaneous electrical stimulation Handgrip strength Nerve block Randomized controlled trial |
| description |
Background/Objectives: Preclinical studies have evidenced a peripheral nerve blockade with kilohertz high-frequency alternating current (KHFAC) stimulation. It could have a potential effect on aberrant nerve hyperactivity, such as tremor in people with Parkinson’s disease (PwPD). The objective was to investigate the effects of transcutaneous KHFAC at 10 kHz compared with sham intervention on tremor modulation, upper limb motor function, and adverse events in PwPD. Methods: This randomized, double-blind, crossover trial included PwPD, who received transcutaneous KHFAC and sham interventions, within a 48 h washout period. Measurements were taken pre-intervention, during, immediately after, and 10 min post-intervention. The main outcomes were rest, postural, and kinetic tremor acceleration. Secondary outcomes were handgrip strength, nine-hole peg test (NHPT), movement onset time, and adverse events. Results: Sixteen PwPD were analyzed. Kinetic tremor diminished only in active treatment from baseline at post-intervention (−32.3% (SD 63.3); p = 0.03) and 10 min after intervention (−38.9% (SD 60.3); p = 0.03). Active treatment showed a greater reduction in kinetic tremor at post-treatment compared to sham (−58.7% SD 123; p = 0.055) close to reaching statistical significance. Only active intervention diminished movement onset time at post-intervention (−26.9% (SD 28.3); p = 0.04). Active intervention diminished handgrip strength compared to sham intervention during the stimulation (−6.6% (SD 10.0); p = 0.02). No relevant adverse effects were reported. Conclusions: KHFAC stimulation at 10 kHz appeared safe and showed potential benefits for reducing kinetic tremor in PwPD. The transient reduction in grip strength suggested an effect on alpha-motoneurons. However, further studies with larger sample sizes are necessary to confirm these findings. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/375469 |
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http://hdl.handle.net/10261/375469 |
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Inglés |
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Inglés |
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#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119752RA-I00 The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/jcm13247566 Avendaño Coy, J.; Fernández Pérez, J. J.; Serrano Muñoz, D.; Gomez Soriano, J.; 2024; Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson's Disease: A double-blind, randomized, crossover study [Dataset]; Zenodo; v.1; https://doi.org/10.5281/zenodo.14093286 https://doi.org/10.3390/jcm13247566 Sí |
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Multidisciplinary Digital Publishing Institute |
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Multidisciplinary Digital Publishing Institute |
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