The Space of Disse: The Liver Hub in Health and Disease

Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between the endothelial cells and hepatocytes filled with blood plasma, have acquired great importance in liver disease. The...

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Detalles Bibliográficos
Autores: Sanz García, Carlos, Fernández Iglesias, Anabel, Gracia Sancho, Jordi, Arráez Aybar, Luis Alfonso, Nevzorova, Yulia, Cubero Palero, Francisco Javier
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7354
Acceso en línea:https://hdl.handle.net/20.500.14352/7354
Access Level:acceso abierto
Palabra clave:616.3
612.017
Chronic liver disease
Hepatic stellate cells (HSCs)
Liver sinusoidal endothelial cells (LSECs)
Fibrosis
Kupffer cells (KCs)
Extracellular matrix (ECM)
Medicina
Gastroenterología y hepatología
Inmunología
32 Ciencias Médicas
3205.03 Gastroenterología
2412 Inmunología
id ES_3dcc6e2b7f71d1811d618cb260c2fcef
oai_identifier_str oai:docta.ucm.es:20.500.14352/7354
network_acronym_str ES
network_name_str España
repository_id_str
spelling The Space of Disse: The Liver Hub in Health and DiseaseSanz García, CarlosFernández Iglesias, AnabelGracia Sancho, JordiArráez Aybar, Luis AlfonsoNevzorova, YuliaCubero Palero, Francisco Javier616.3612.017Chronic liver diseaseHepatic stellate cells (HSCs)Liver sinusoidal endothelial cells (LSECs)FibrosisKupffer cells (KCs)Extracellular matrix (ECM)MedicinaGastroenterología y hepatologíaInmunología32 Ciencias Médicas3205.03 Gastroenterología2412 InmunologíaSince it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between the endothelial cells and hepatocytes filled with blood plasma, have acquired great importance in liver disease. The space of Disse is home for the hepatic stellate cells (HSCs), the major fibrogenic players in the liver. Quiescent HSCs (qHSCs) store vitamin A, and upon activation they lose their retinol reservoir and become activated. Activated HSCs (aHSCs) are responsible for secretion of extracellular matrix (ECM) into the space of Disse. This early event in hepatic injury is accompanied by loss of the pores—known as fenestrations—of the endothelial cells, triggering loss of balance between the blood flow and the hepatocyte, and underlies the link between fibrosis and organ dysfunction. If the imbalance persists, the expansion of the fibrotic scar followed by the vascularized septae leads to cirrhosis and/or end-stage hepatocellular carcinoma (HCC). Thus, researchers have been focused on finding therapeutic targets that reduce fibrosis. The space of Disse provides the perfect microenvironment for the stem cells niche in the liver and the interchange of nutrients between cells. In the present review article, we focused on the space of Disse, its components and its leading role in liver disease development.MDPIUniversidad Complutense de Madrid20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7354reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/73542026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Space of Disse: The Liver Hub in Health and Disease
title The Space of Disse: The Liver Hub in Health and Disease
spellingShingle The Space of Disse: The Liver Hub in Health and Disease
Sanz García, Carlos
616.3
612.017
Chronic liver disease
Hepatic stellate cells (HSCs)
Liver sinusoidal endothelial cells (LSECs)
Fibrosis
Kupffer cells (KCs)
Extracellular matrix (ECM)
Medicina
Gastroenterología y hepatología
Inmunología
32 Ciencias Médicas
3205.03 Gastroenterología
2412 Inmunología
title_short The Space of Disse: The Liver Hub in Health and Disease
title_full The Space of Disse: The Liver Hub in Health and Disease
title_fullStr The Space of Disse: The Liver Hub in Health and Disease
title_full_unstemmed The Space of Disse: The Liver Hub in Health and Disease
title_sort The Space of Disse: The Liver Hub in Health and Disease
dc.creator.none.fl_str_mv Sanz García, Carlos
Fernández Iglesias, Anabel
Gracia Sancho, Jordi
Arráez Aybar, Luis Alfonso
Nevzorova, Yulia
Cubero Palero, Francisco Javier
author Sanz García, Carlos
author_facet Sanz García, Carlos
Fernández Iglesias, Anabel
Gracia Sancho, Jordi
Arráez Aybar, Luis Alfonso
Nevzorova, Yulia
Cubero Palero, Francisco Javier
author_role author
author2 Fernández Iglesias, Anabel
Gracia Sancho, Jordi
Arráez Aybar, Luis Alfonso
Nevzorova, Yulia
Cubero Palero, Francisco Javier
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.3
612.017
Chronic liver disease
Hepatic stellate cells (HSCs)
Liver sinusoidal endothelial cells (LSECs)
Fibrosis
Kupffer cells (KCs)
Extracellular matrix (ECM)
Medicina
Gastroenterología y hepatología
Inmunología
32 Ciencias Médicas
3205.03 Gastroenterología
2412 Inmunología
topic 616.3
612.017
Chronic liver disease
Hepatic stellate cells (HSCs)
Liver sinusoidal endothelial cells (LSECs)
Fibrosis
Kupffer cells (KCs)
Extracellular matrix (ECM)
Medicina
Gastroenterología y hepatología
Inmunología
32 Ciencias Médicas
3205.03 Gastroenterología
2412 Inmunología
description Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between the endothelial cells and hepatocytes filled with blood plasma, have acquired great importance in liver disease. The space of Disse is home for the hepatic stellate cells (HSCs), the major fibrogenic players in the liver. Quiescent HSCs (qHSCs) store vitamin A, and upon activation they lose their retinol reservoir and become activated. Activated HSCs (aHSCs) are responsible for secretion of extracellular matrix (ECM) into the space of Disse. This early event in hepatic injury is accompanied by loss of the pores—known as fenestrations—of the endothelial cells, triggering loss of balance between the blood flow and the hepatocyte, and underlies the link between fibrosis and organ dysfunction. If the imbalance persists, the expansion of the fibrotic scar followed by the vascularized septae leads to cirrhosis and/or end-stage hepatocellular carcinoma (HCC). Thus, researchers have been focused on finding therapeutic targets that reduce fibrosis. The space of Disse provides the perfect microenvironment for the stem cells niche in the liver and the interchange of nutrients between cells. In the present review article, we focused on the space of Disse, its components and its leading role in liver disease development.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7354
url https://hdl.handle.net/20.500.14352/7354
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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