CLA+ T cell response to microbes in psoriasis

Streptococcus pyogenes throat infection is a clinically relevant trigger of both guttate and chronic plaque psoriasis, and it provides an ideal context in which to study the pathogenesis of these diseases using an antigen-dependent approach. Circulating cutaneous lymphocyte-associated antigen (CLA)...

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Autores: De Jesús Gil, Carmen, Ruiz Romeu, Ester, Ferran, Marta, Chiriac, Anca, Deza, Gustavo, Hóllo, Péter, Celada Cotarelo, Antonio, Pujol, Ramon M., Santamaria Babí, Luis F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/139505
Acceso en línea:https://hdl.handle.net/2445/139505
Access Level:acceso abierto
Palabra clave:Psoriasi
Psoriasis
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spelling CLA+ T cell response to microbes in psoriasisDe Jesús Gil, CarmenRuiz Romeu, EsterFerran, MartaChiriac, AncaDeza, GustavoHóllo, PéterCelada Cotarelo, AntonioPujol, Ramon M.Santamaria Babí, Luis F.PsoriasiPsoriasisStreptococcus pyogenes throat infection is a clinically relevant trigger of both guttate and chronic plaque psoriasis, and it provides an ideal context in which to study the pathogenesis of these diseases using an antigen-dependent approach. Circulating cutaneous lymphocyte-associated antigen (CLA) positive (+) memory T cells are a subset of peripheral lymphocytes whose phenotype and function are related to immunological mechanisms in the skin. These cells are considered peripheral biomarkers of T-cell-mediated skin diseases. The coculture of autologous epidermal cells with CLA+ T cells from psoriasis patients activated by S. pyogenes allows the reproduction of the ex vivo initial molecular events that occur during psoriatic lesion formation. With cooperation of autologous epidermal cells, S. pyogenes selectively activates CLA+ T cells both in guttate and plaque psoriasis, inducing key mediators, including an IL-17 response. Here, we explore potential new mechanisms of psoriasis development including the influence of HLA-Cw6 on S. pyogenes CLA+ T cell activation in guttate psoriasis, the relevance of IL-9 on microbe induced IL-17 response in guttate and plaque psoriasis, and novel effector functions of Candida albicans. This review will summarize recent knowledge of psoriatic mechanisms elicited by microbes that have been studied through an innovative translational perspective based on CLA+ T cell-mediated cutaneous immune response.Frontiers Media2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/139505Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.01488Frontiers in Immunology, 2018, vol. 9, p. 1488https://doi.org/10.3389/fimmu.2018.01488cc-by (c) De Jesús Gil, Carmen et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1395052026-05-29T05:05:01Z
dc.title.none.fl_str_mv CLA+ T cell response to microbes in psoriasis
title CLA+ T cell response to microbes in psoriasis
spellingShingle CLA+ T cell response to microbes in psoriasis
De Jesús Gil, Carmen
Psoriasi
Psoriasis
title_short CLA+ T cell response to microbes in psoriasis
title_full CLA+ T cell response to microbes in psoriasis
title_fullStr CLA+ T cell response to microbes in psoriasis
title_full_unstemmed CLA+ T cell response to microbes in psoriasis
title_sort CLA+ T cell response to microbes in psoriasis
dc.creator.none.fl_str_mv De Jesús Gil, Carmen
Ruiz Romeu, Ester
Ferran, Marta
Chiriac, Anca
Deza, Gustavo
Hóllo, Péter
Celada Cotarelo, Antonio
Pujol, Ramon M.
Santamaria Babí, Luis F.
author De Jesús Gil, Carmen
author_facet De Jesús Gil, Carmen
Ruiz Romeu, Ester
Ferran, Marta
Chiriac, Anca
Deza, Gustavo
Hóllo, Péter
Celada Cotarelo, Antonio
Pujol, Ramon M.
Santamaria Babí, Luis F.
author_role author
author2 Ruiz Romeu, Ester
Ferran, Marta
Chiriac, Anca
Deza, Gustavo
Hóllo, Péter
Celada Cotarelo, Antonio
Pujol, Ramon M.
Santamaria Babí, Luis F.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psoriasi
Psoriasis
topic Psoriasi
Psoriasis
description Streptococcus pyogenes throat infection is a clinically relevant trigger of both guttate and chronic plaque psoriasis, and it provides an ideal context in which to study the pathogenesis of these diseases using an antigen-dependent approach. Circulating cutaneous lymphocyte-associated antigen (CLA) positive (+) memory T cells are a subset of peripheral lymphocytes whose phenotype and function are related to immunological mechanisms in the skin. These cells are considered peripheral biomarkers of T-cell-mediated skin diseases. The coculture of autologous epidermal cells with CLA+ T cells from psoriasis patients activated by S. pyogenes allows the reproduction of the ex vivo initial molecular events that occur during psoriatic lesion formation. With cooperation of autologous epidermal cells, S. pyogenes selectively activates CLA+ T cells both in guttate and plaque psoriasis, inducing key mediators, including an IL-17 response. Here, we explore potential new mechanisms of psoriasis development including the influence of HLA-Cw6 on S. pyogenes CLA+ T cell activation in guttate psoriasis, the relevance of IL-9 on microbe induced IL-17 response in guttate and plaque psoriasis, and novel effector functions of Candida albicans. This review will summarize recent knowledge of psoriatic mechanisms elicited by microbes that have been studied through an innovative translational perspective based on CLA+ T cell-mediated cutaneous immune response.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/139505
url https://hdl.handle.net/2445/139505
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.01488
Frontiers in Immunology, 2018, vol. 9, p. 1488
https://doi.org/10.3389/fimmu.2018.01488
dc.rights.none.fl_str_mv cc-by (c) De Jesús Gil, Carmen et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) De Jesús Gil, Carmen et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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